The vestibulothalamic projections in the cat studied by retrograde axonal transport of horseradish peroxidase

SummaryHorseradish peroxidase (HRP) was injected or iontophoretically ejected in various thalamic nuclei in 63 adult cats. In 11 other animals HRP was deposited outside the thalamic territory. The number and distribution of labelled cells within the vestibular nuclear complex (VC) were mapped in each case. To a varying degree all subgroups of VC appear to contribute to the vestibulothalamic projections. Such fibres are distributed to several thalamic areas. From the present investigation it appears that generally speaking, there exist three distinct vestibulothalamic pathways with regard to origin as well as to site of termination of the fibres. One projection appears to originate mainly in caudal parts of the medial (M) and descending (D) vestibular nuclei and in cell group z. This pathway terminates chiefly in the contralateral medial part of the posterior nucleus of the thalamus (POm) including the magnocellular part of the medial geniculate body (Mgmc), the ventrobasal complex (VB) and the area of the ventral lateral nucleus (VL) bordering on VB. A second projection originates mainly in the superior vestibular nucleus (S) and in cell group y and terminates mainly in the contralateral nucleus centralis lateralis (CL) and the adjoining nucleus paracentralis (Pc). A third, more modest, pathway originates chiefly in the middle M and D, with a minor contribution from S and cell group y, and terminates in the contralateral ventral nucleus of the lateral geniculate body (GLV). There is some degree of overlap between the origin of these three vestibulothalamic pathways.

[1]  R. Tasker,et al.  Vestibulothalamic projections in man--a sixth primary sensory pathway. , 1978, Journal of neurophysiology.

[2]  O. Pompeiano,et al.  Spino‐vestibular fibers in the cat. An experimental study , 1957, The Journal of comparative neurology.

[3]  A. Brodal,et al.  Anatomy of the Vestibular Nuclei and their Connections , 1974 .

[4]  H. Nauta,et al.  Afferents to the rat caudoputamen studied with horseradish peroxidase. An evaluation of a retrograde neuroanatomical research method. , 1974, Brain research.

[5]  J. M. Fredrickson,et al.  Vestibular responses in the Rhesus monkey ventroposterior thalamus. II. Vestibulo-proprioceptive convergence at thalamic neurons , 1977, Experimental Brain Research.

[6]  R. Marty,et al.  Projections thalamiques des noyaux vestibulaires: Etude histologique chez le chat , 1974, Experimental Brain Research.

[7]  A BRODAL,et al.  The origin of ascending fibres of the medial longitudinal fasciculus from the vestibular nuclei; an experimental study in the cat. , 1958, Acta morphologica Neerlando-Scandinavica.

[8]  E. Rinvik.  A re-evaluation of the cytoarchitecture of the ventral nuclear complex of the cat's thalamus on the basis of corticothalamic connections. , 1968, Brain research.

[9]  K. Kristensson,et al.  Projection of thalamic neurons to cat primary vestibular cortical fields studied by means of retrograde axonal transport of horseradish peroxidase , 1976, Experimental Brain Research.

[10]  S. Highstein,et al.  Vestibular nucleus neurons relaying excitation from the anterior canal to the oculomotor nucleus , 1978, Brain Research.

[11]  J. Boivie.  An anatomical reinvestigation of the termination of the spinothalamic tract in the monkey , 1979, The Journal of comparative neurology.

[12]  Sid Gilman,et al.  Brain stem pathways for vestibular projections to cerebral cortex in the cat , 1977, Experimental Neurology.

[13]  H. Burton,et al.  Cytoarchitecture and somatic sensory connectivity of thalamic nuclei other than the ventrobasal complex in the cat , 1974, The Journal of comparative neurology.

[14]  V. Henn,et al.  Vestibular-related neuronal activity in the thalamus of the alert monkey during sinusoidal rotation in the dark , 1977, Experimental Brain Research.

[15]  R. Hassler.  Die zentralen Apparate der Wendebewegungen , 1956, Archiv für Psychiatrie und Nervenkrankheiten.

[16]  S. Gilman,et al.  Vestibular, somatosensory, and auditory input to the thalamus of the cat , 1979, Experimental Neurology.

[17]  E. G. Szekely,et al.  VESTIBULAR RESPONSES IN MIDBRAIN, THALAMUS, AND BASAL GANGLIA. , 1965, Archives of neurology.

[18]  H. Silfvenius,et al.  Course and termination of fibres from the nucleus Z of the medulla oblongata. An experimental light microscopical study in the cat. , 1973, Brain research.

[19]  M. Mesulam,et al.  Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. , 1978, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[20]  R. Hassler.  Forels Haubenfaszikel als vestibuläre Empfindungsbahn mit Bemerkungen über einige andere sekundäre Bahnen des Vestibularis und Trigeminus , 2004, Archiv für Psychiatrie und Nervenkrankheiten.

[21]  E. Tarlov.  The rostral projections of the primate vestibular nuclei: An experimental study in macaque, baboon and chimpanzee , 1969, The Journal of comparative neurology.

[22]  M. Mesulam,et al.  The blue reaction product in horseradish peroxidase neurohistochemistry: incubation parameters and visibility. , 1976, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[23]  I. Donaldson.  Control of gaze by brain stem neurons Proceedings of the symposium held in the Abbaye de Royaumont. Paris 12–15 July, 1977.Developments in Neuroscience, vol. 1.R. Baker &A. Berthoz (eds). Elsevier/North Holland Biomedical Press, Amsterdam (1977). 514 + xv pp., $59.95 , 1978, Neuroscience.

[24]  M. Carpenter,et al.  Lesions of the medial longitudinal fasciculus in the cat. , 1962, The American journal of anatomy.

[25]  M. Magnin,et al.  A new vestibular thalamic area: Electrophysiological study of the thalamic reticular nucleus and of the ventral lateral geniculate complex of the cat , 1978, Experimental Brain Research.

[26]  J. Boivie.  The termination of the spinothalamic tract in the cat an experimental study with silver impregnation methods , 1971, Experimental Brain Research.

[27]  R. Robertson,et al.  The corticothalamic projections from parietal regions of the cerebral cortex. Experimental degeneration studies in the cat. , 1973, Brain research.

[28]  U. Büttner,et al.  Vestibular projections to the monkey thalamus: An autoradiographic study , 1979, Brain Research.

[29]  M. Karnovsky,et al.  THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUE , 1966, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[30]  K. Kalil.  Patch-like termination of thalamic fibers in the putamen of the rhesus monkey: an autoradiographic study , 1978, Brain Research.

[31]  F. Walberg,et al.  Afferent projections to the thalamus from the perihypoglossal nuclei , 1980, Brain Research.

[32]  O. Pompeiano,et al.  The vestibular nuclei in cat. , 1957, Journal of anatomy.

[33]  M. Yahr,et al.  Corticothalamic projections and sensorimotor activities , 1972 .

[34]  S. Gilman,et al.  Vestibular, auditory, and somatic input to the posterior thalamus of the cat , 2004, Experimental Brain Research.

[35]  G. J. Royce.  Autoradiographic evidence for a discontinuous projection to the caudate nucleus from the centromedian nucleus in the cat , 1978, Brain Research.

[36]  M. Carpenter,et al.  The medial longitudinal fasciculus and disturbances of conjugate horizontal eye movements in the monkey , 1965, The Journal of comparative neurology.

[37]  J. Raymond,et al.  [Thalamic and cortical responses to electric stimulation of the vestibular nerve in the cat]. , 1970, Experimental brain research.

[38]  S. Landgren,et al.  Nucleus Z, the medullary relay in the projection path to the cerebral cortex of group I muscle afferents from the cat's hind limb , 1971, The Journal of physiology.

[39]  J. M. Fredrickson,et al.  Nucleus ventroposterior inferior (VPI) as the vestibular thalamic relay in the rhesus monkey I. Field potential investigation , 1974, Experimental Brain Research.

[40]  R. Gacek.  The course and central termination of first order neurons supplying vestibular endorgans in the cat. , 1969, Acta oto-laryngologica. Supplementum.

[41]  F. Condé,et al.  Thalamic projections of the vestibular nuclei in the cat as revealed by retrograde transport of horseradish peroxidase , 1978, Neuroscience Letters.

[42]  N. Boisacq-Schepens,et al.  Ascending vestibular projections: Further results at cortical and thalamic levels in the cat , 1977, Experimental Brain Research.

[43]  E. Jones,et al.  Retrograde axonal transport and the demonstration of non‐specific projections to the cerebral cortex and striatum from thalamic intralaminar nuclei in the rat, cat and monkey , 1974, The Journal of comparative neurology.

[44]  W. F. Poon,et al.  An electrophysiological study of the sacculo-ocular pathways in cats. , 1975, The Japanese journal of physiology.

[45]  Donald A. Keefer,et al.  Horseradish peroxidase as a retrogradely-transported, detailed dendritic marker , 1978, Brain Research.

[46]  J. Olszewski.  The Thalamus of the Macaca Mulatta: An Atlas for Use with the Stereotaxic Instrument , 1952 .

[47]  H. Jasper,et al.  A stereotaxic atlas of the diencephalon of the cat , 1960 .

[48]  H. Kennedy,et al.  Anatomical evidence of a third ascending vestibular pathway involving the ventral lateral geniculate nucleus and the intralaminar nuclei of the cat , 1979, Brain Research.

[49]  J. Raymond,et al.  A vestibulothalamic pathway: Electrophysiological demonstration in the cat by localized cooling , 1976, Journal of neuroscience research.