MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways

[1]  J. Hayes,et al.  Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. , 2015, Free radical biology & medicine.

[2]  A. Kohlgruber,et al.  Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes , 2015, Current Diabetes Reports.

[3]  C. Proud.  Mnks, eIF4E phosphorylation and cancer. , 2015, Biochimica et biophysica acta.

[4]  Shuye Tian,et al.  The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding. , 2015, The Biochemical journal.

[5]  C. Proud,et al.  BDNF Stimulation of Protein Synthesis in Cortical Neurons Requires the MAP Kinase-Interacting Kinase MNK1 , 2015, The Journal of Neuroscience.

[6]  L. O’Driscoll,et al.  Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies , 2015, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[7]  C. Byrne,et al.  Ectopic Fat, Insulin Resistance, and Nonalcoholic Fatty Liver Disease: Implications for Cardiovascular Disease , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[8]  Qifu Li,et al.  Metformin Ameliorates Hepatic Steatosis and Inflammation without Altering Adipose Phenotype in Diet-Induced Obesity , 2014, PloS one.

[9]  C. Proud,et al.  Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors , 2014, Nucleic acids research.

[10]  M. Yamada,et al.  Nrf2 Activators Attenuate the Progression of Nonalcoholic Steatohepatitis–Related Fibrosis in a Dietary Rat Model , 2013, Molecular Pharmacology.

[11]  P. Iversen,et al.  Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors. , 2013, Blood.

[12]  C. Klaassen,et al.  Genetic Activation of Nrf2 Protects against Fasting-Induced Oxidative Stress in Livers of Mice , 2013, PloS one.

[13]  Stephen T. C. Wong,et al.  Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. , 2013, Cell metabolism.

[14]  N. Sonenberg,et al.  Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E , 2012, Nature Immunology.

[15]  K. Murphy,et al.  Current models and strategies in the development of antiobesity drugs , 2011, Annals of the New York Academy of Sciences.

[16]  Carey N Lumeng,et al.  Inflammatory links between obesity and metabolic disease. , 2011, The Journal of clinical investigation.

[17]  D. James,et al.  Mapping Insulin/GLUT4 Circuitry , 2011, Traffic.

[18]  L. Thibault,et al.  High-fat diet-induced obesity in animal models , 2010, Nutrition Research Reviews.

[19]  L. Sanderson,et al.  Transcriptional profiling reveals divergent roles of PPARalpha and PPARbeta/delta in regulation of gene expression in mouse liver. , 2010, Physiological genomics.

[20]  S. Klein,et al.  Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications , 2010, Hepatology.

[21]  Y. Zick,et al.  Phosphorylation of IRS proteins, insulin action, and insulin resistance. , 2009, American journal of physiology. Endocrinology and metabolism.

[22]  B. Porse,et al.  Bone Marrow-Derived Macrophages (BMM): Isolation and Applications. , 2008, CSH protocols.

[23]  C. Proud,et al.  The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases). , 2008, Frontiers in bioscience : a journal and virtual library.

[24]  C. Proud,et al.  The PSF·p54nrb Complex Is a Novel Mnk Substrate That Binds the mRNA for Tumor Necrosis Factor α* , 2008, Journal of Biological Chemistry.

[25]  A. Saltiel,et al.  Obesity induces a phenotypic switch in adipose tissue macrophage polarization. , 2007, The Journal of clinical investigation.

[26]  S. Nagata,et al.  Mnk2 and Mnk1 Are Essential for Constitutive and Inducible Phosphorylation of Eukaryotic Initiation Factor 4E but Not for Cell Growth or Development , 2004, Molecular and Cellular Biology.

[27]  G. Scheper,et al.  Features in the N and C Termini of the MAPK-interacting Kinase Mnk1 Mediate Its Nucleocytoplasmic Shuttling* , 2003, Journal of Biological Chemistry.

[28]  G. Scheper,et al.  The N and C Termini of the Splice Variants of the Human Mitogen-Activated Protein Kinase-Interacting Kinase Mnk2 Determine Activity and Localization , 2003, Molecular and Cellular Biology.

[29]  Michael Karin,et al.  A central role for JNK in obesity and insulin resistance , 2002, Nature.

[30]  G. Scheper,et al.  The Mitogen-Activated Protein Kinase Signal-Integrating Kinase Mnk2 Is a Eukaryotic Initiation Factor 4E Kinase with High Levels of Basal Activity in Mammalian Cells , 2001, Molecular and Cellular Biology.

[31]  L. New,et al.  Phosphorylation of eIF-4E on Ser 209 in response to mitogenic and inflammatory stimuli is faithfully detected by specific antibodies. , 2000, Molecular cell biology research communications : MCBRC.

[32]  B. Vanhaesebroeck,et al.  The PI3K-PDK1 connection: more than just a road to PKB. , 2000, The Biochemical journal.

[33]  Jonathan A. Cooper,et al.  Phosphorylation of the Cap-Binding Protein Eukaryotic Translation Initiation Factor 4E by Protein Kinase Mnk1 In Vivo , 1999, Molecular and Cellular Biology.

[34]  Jonathan A. Cooper,et al.  The Phosphorylation of Eukaryotic Initiation Factor eIF4E in Response to Phorbol Esters, Cell Stresses, and Cytokines Is Mediated by Distinct MAP Kinase Pathways* , 1998, The Journal of Biological Chemistry.

[35]  Jonathan A. Cooper,et al.  Mitogen‐activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 , 1997, The EMBO journal.

[36]  P. Smith,et al.  Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes. , 1988, The Journal of biological chemistry.

[37]  R. Turner,et al.  Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man , 1985, Diabetologia.