论文信息 - An enzyme-scissile linker for solid-phase peptide synthesis - 字舞流文

An enzyme-scissile linker for solid-phase peptide synthesis

We describe a new linker that contains a phosphodiester moiety for solid-phase peptide synthesis; after completion of the cycle of coupling and deprotection steps, the phosphodiester can be cleaved with phosphodiesterase.

D. Guthrie | A. Wallace | S. Bates | D. Elmore

[1] R. B. Merrifield,et al. Photolabile multi-detachable p-alkoxybenzyl alcohol resin supports for peptide fragment or semi-synthesis. , 2009, International journal of peptide and protein research.

[2] M. Gairí,et al. Convergent solid-phase peptide synthesis. X. Synthesis and purification of protected peptide fragments using the photolabile Nbb-resin☆☆☆ , 1991 .

[3] D. Mullen,et al. A new fluoridolyzable anchoring linkage for orthogonal solid-phase peptide synthesis: design, preparation, and application of the N-(3 or 4)-[[4-(hydroxymethyl)phenoxy]-tert-butylphenylsilyl]phenyl pentanedioic acid monoamide (Pbs) handle , 1988 .

[4] E. Felder,et al. The CAMET and CASET links for the synthesis of protected oligopeptides and oligodeoxynucleotides on solid and soluble supports , 1984 .

[5] A. Ajayaghosh,et al. Polymer-supported synthesis of protected peptide segments on a photosensitive o-nitro(a-methyl)bromobenzyl resin , 1988 .

[6] D. Mullen,et al. A new fluoridolysable anchoring linkage for orthogonal solid-phase peptide synthesis: Preparation and properties of the N-(3 or 4)-[[[(4-hydroxymethyl)-phenoxy-t-butylphenyl]silyl]phenyl]pentanedioic acid, monoamide (PBS) handle☆☆☆ , 1987 .

[7] S. Bielecki,et al. Solid phase peptide synthesis: Fluoride ion release of peptide from the resin , 1987 .