Locally advanced breast carcinoma: computer assisted semiquantitative analysis of color Doppler ultrasonography in the evaluation of tumor response to neoadjuvant chemotherapy (work in progress).

We aimed to evaluate objectively the value of color Doppler flow imaging in the assessment of response of locally advanced breast cancer to primary medical treatment by using a computer assisted semiquantitative method. Prior to and after neoadjuvant treatment, 17 patients with locally advanced breast carcinoma were prospectively evaluated by physical examination and computer assisted semiquantitative color Doppler ultrasonography. The results of clinical and color Doppler examination were finally correlated to the histopathologic evaluation of tumor response. The degree of concordance between posttherapeutic histopathologic results, clinical examination, and color Doppler assessment was evaluated by kappa statistics. Concordance was 0.474 (0.135‐0.813) between histopathologic results and clinical posttherapeutic assessment and 0.870 (0.627‐1.113) between histopathologic results and semiquantitative color Doppler examination. Objective semiquantitative assessment of tumor vascularity as displayed by color Doppler ultrasonography has potential as a functional tool for measuring tumor response to neoadjuvant chemotherapy.

[1]  Barney M. Berlin,et al.  Size , 1989, Encyclopedia of Evolutionary Psychological Science.

[2]  S E Harms,et al.  Evaluation of neoadjuvant chemotherapeutic response of locally advanced breast cancer by magnetic resonance imaging , 1996, Cancer.

[3]  J E Husband,et al.  Primary breast cancer: mammographic changes after neoadjuvant chemotherapy, with pathologic correlation. , 1996, Radiology.

[4]  G. van Kaick,et al.  Quantitative characterization of color Doppler images: Reproducibility, accuracy, and limitations , 1995, Journal of clinical ultrasound : JCU.

[5]  T. Powles,et al.  Randomized trial of chemoendocrine therapy started before or after surgery for treatment of primary breast cancer. , 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  K. Dardoufas,et al.  Locally advanced breast cancer : application of all available therapeutic modelities , 1995 .

[7]  G. van Kaick,et al.  Quantification of color Doppler for the evaluation of tissue vascularization. , 1995, Ultrasound in medicine & biology.

[8]  D. S. Bell,et al.  Segmentation and analysis of colour Doppler images of tumour vasculature. , 1995, Ultrasound in medicine & biology.

[9]  G Brix,et al.  MR mammography with pharmacokinetic mapping for monitoring of breast cancer treatment during neoadjuvant therapy. , 1994, Magnetic resonance imaging clinics of North America.

[10]  M. Kaufmann,et al.  Histologische Regression des Mammakarzinoms nach primärer (neoadjuvanter) Chemotherapie , 1994 .

[11]  M V Knopp,et al.  Breast tumors: computer-assisted quantitative assessment with color Doppler US. , 1994, Radiology.

[12]  R. Gilles,et al.  Locally advanced breast cancer: contrast-enhanced subtraction MR imaging of response to preoperative chemotherapy. , 1994, Radiology.

[13]  D O Cosgrove,et al.  Breast carcinoma: measurement of tumor response to primary medical therapy with color Doppler flow imaging. , 1994, Radiology.

[14]  J. Hogg.  Magnetic resonance imaging. , 1994, Journal of the Royal Naval Medical Service.

[15]  J B Davey,et al.  Breast diseases: color Doppler US in differential diagnosis. , 1993, Radiology.

[16]  D. King,et al.  Mammography in the assessment of response to medical treatment of large primary breast cancer. , 1993, Clinical radiology.

[17]  Q. Han,et al.  [Management of stage III primary breast cancer. An analysis of 221 cases]. , 1992, Zhonghua wai ke za zhi [Chinese journal of surgery].

[18]  U. Chetty,et al.  Colour Doppler ultrasonography studies of benign and malignant breast lesions , 1992, The British journal of surgery.

[19]  A. Luini,et al.  Primary chemotherapy to avoid mastectomy in tumors with diameters of three centimeters or more. , 1990, Journal of the National Cancer Institute.

[20]  C. Jacquillat,et al.  Results of neoadjuvant chemotherapy and radiation therapy in the breast‐conserving treatment of 250 patients with all stages of infiltrative breast cancer , 1990, Cancer.

[21]  J B Davey,et al.  Color Doppler signals from breast tumors. Work in progress. , 1990, Radiology.

[22]  M. Merino,et al.  The effects of hormonal and chemotherapy on tumoral and nonneoplastic breast tissue. , 1990, Human pathology.

[23]  J A McKinna,et al.  Primary medical therapy for operable breast cancer. , 1989, European journal of cancer & clinical oncology.

[24]  G. Hortobagyi,et al.  Management of stage III primary breast cancer with primary chemotherapy, surgery, and radiation therapy , 1988, Cancer.

[25]  G. Hortobagyi,et al.  Advanced primary breast cancer: assessment at mammography of response to induction chemotherapy. , 1988, Radiology.

[26]  B. Fornage,et al.  Clinical, mammographic, and sonographic determination of preoperative breast cancer size , 1987, Cancer.

[27]  S. Steinberg,et al.  Neoadjuvant chemotherapy in the combined modality approach of locally advanced nonmetastatic breast cancer. , 1987, Cancer research.

[28]  S. Friedman,et al.  Primary chemotherapy in the treatment of inflammatory breast carcinoma: a study of 230 cases from the Institut Gustave-Roussy. , 1986, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[29]  G. Hortobagyi,et al.  Pathological assessment of response to induction chemotherapy in breast cancer. , 1986, Cancer research.

[30]  J. Goldie,et al.  Neoadjuvant (preoperative) chemotherapy for breast cancer , 1985, Cancer.

[31]  G. Hortobagyi,et al.  Multimodal treatment of locoregionally advanced breast cancer , 1983, Cancer.

[32]  H. Libshitz,et al.  Calcifications and the therapeutically irradiated breast. , 1977, AJR. American journal of roentgenology.

[33]  R. Rubens,et al.  Assessment of response to therapy in advanced breast cancer. , 1977, British Journal of Cancer.

[34]  B. Weissman,et al.  Mammography of the definitively irradiated breast. , 1976, Radiology.