论文信息 - Chromosome assignments of the human TNF p55 and p75 receptor genes.

Chromosome assignments of the human TNF p55 and p75 receptor genes.

At least two different receptor molecules have been described that are capable of binding tumor necrosis factor alpha, a cytokine that plays an important role in inflammation and antitumor activity. Comparative analyses at the nucleotide sequence level suggest that these receptors are members of a newly defined protein family that also includes human and rat nerve growth factor receptors. In this study, we determine the chromosome assignments of the human TNF alpha receptor genes, one of which may have evolved as part of a conserved Hox locus-containing chromosome segment.

[1] K. Tracey,et al. Peptide Regulatory Factors CACHECTIN/TUMOUR NECROSIS FACTOR , 1989, The Lancet.

[2] G. Wong,et al. Molecular cloning and expression of a receptor for human tumor necrosis factor , 1990, Cell.

[3] M. Carty,et al. cDNA cloning and mapping of the human creatine kinase M gene to 19q13. , 1987, American journal of human genetics.

[4] C. Smith,et al. A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. , 1990, Science.

[5] C. P. Hart,et al. Cognate homeo-box loci mapped on homologous human and mouse chromosomes. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[6] H. Tabuchi,et al. Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor , 1990, Cell.

[7] B. Beutler,et al. Cachectin: more than a tumor necrosis factor. , 1987, The New England journal of medicine.

[8] M. T. Brewer,et al. A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[9] N. Copeland,et al. Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor , 1991, Molecular and cellular biology.