DETERMINANTS OF THYROID VOLUME AS MEASURED BY ULTRASONOGRAPHY IN HEALTHY ADULTS IN A NON‐IODINE DEFICIENT AREA

Thyroid volume was measured by ultrasonography in 50 healthy adults (25 males, 25 females, age 20‐70 years) living in the non‐iodine deficient area of Amsterdam. Thyroid volume was 10‐7 ± 4–6 ml (mean ± SD, range 2.7‐20.4 ml). No relation was found between thyroid volume and any of the following parameters: plasma TSH, T4, T3, thyroglobulin (Tg), urinary iodine excretion, tobacco and alcohol consumption. Thyroid volume in males (12.7 ± 4.4 ml) was greater than in females (8.7 ± 3.9 ml, p = 0.0014), but no sex difference was observed in the ratio of thyroid volume to body weight (males, 0.16 ± 005 ml/ kg; females 013 ± 0.06 ml/kg; NS). Thyroid volume was positively related to body weight, but not to age. We conclude that the sex difference in thyroid volume is due to the difference in body weight between males and females. Lean body mass is presumably the most important physiological determinant of thyroid size in subjects living in a non‐iodine deficient area.

[1]  U. Cerletti.  [Endemic goiter]. , 1951, Lo sperimentale.

[2]  R. M.,et al.  The Thyroid Gland , 1894, Nature.

[3]  B. Hetzel,et al.  Endemic goitre and cretinism: public health significance and prevention. , 1974, WHO chronicle.

[4]  Subcommitteeforthestudyofende.  Goitre and Iodine Deficiency in Europe , 1985 .

[5]  A. Vermeulen,et al.  Demonstration of nodules in the normal thyroid by echography. , 1985, The British journal of radiology.

[6]  S. Rasmussen,et al.  Determination of thyroid volume by ultrasonic scanning , 1974, Journal of clinical ultrasound : JCU.

[7]  J. Dumont,et al.  The Regulation of Thyroid Cell Metabolism , 1976 .

[8]  J. de Vijlder,et al.  Hereditary congenital goiter with thyroglobulin deficiency in a breed of goats. , 1978, Endocrinology.

[9]  G. Bray.  Increased sensitivity of the thyroid in iodine-depleted rats to the goitrogenic effects of thyrotropin. , 1968, The Journal of clinical investigation.

[10]  M. Molitch,et al.  Aging and the thyroid. Decreased requirement for thyroid hormone in older hypothyroid patients. , 1983, The American journal of medicine.

[11]  B. Carroll.  Asymptomatic thyroid nodules: incidental sonographic detection. , 1982, AJR. American journal of roentgenology.

[12]  G. Milles.  Pathology of the thyroid. , 1949, American practitioner and digest of treatment.

[13]  C. Havard.  The thyroid and ageing. , 1981 .

[14]  THE THYROID. , 1965, Annual review of physiology.

[15]  U. Barzel,et al.  Levothyroxine replacement dose for primary hypothyroidism decreases with age. , 1982, Annals of internal medicine.

[16]  U. Barzel,et al.  Lean Body Mass is a Predictor of the Daily Requirement for Thyroid Hormone in Older Men and Women , 1984, Journal of the American Geriatrics Society.

[17]  U. Kapil.  Iodine deficiency. , 1986, Indian pediatrics.

[18]  L. Hegedüs,et al.  HIGH FREQUENCY OF GOITRE IN CIGARETTE SMOKERS , 1985, Clinical endocrinology.

[19]  R. Gärtner,et al.  Involvement of cyclic AMP, iodide and metabolites of arachidonic acid in the regulation of cell proliferation of isolated porcine thyroid follicles , 1985, Molecular and Cellular Endocrinology.

[20]  L. Hegedüs,et al.  The determination of thyroid volume by ultrasound and its relationship to body weight, age, and sex in normal subjects. , 1983, The Journal of clinical endocrinology and metabolism.

[21]  D. S. Riggs,et al.  Endemic Goiter. The Adaptation of Man to Iodine Deficiency , 1954 .

[22]  BODY COMPOSITION IN NORMAL ADULTS , 1965 .

[23]  L. Hegedüs.  Decreased thyroid gland volume in alcoholic cirrhosis of the liver. , 1984, The Journal of clinical endocrinology and metabolism.

[24]  A. Melander,et al.  Influence of cigarette smoking on goiter formation, thyroglobulin, and thyroid hormone levels in women. , 1984, The Journal of clinical endocrinology and metabolism.

[25]  A. J. Herle,et al.  Radioimmunoassay for measurement of thyroglobulin in human serum. , 1973, The Journal of clinical investigation.