Expression of γ-Glutamyl Transpeptidase Activity i Mouse Tooth, Intervertebral Disc, and Hair Follicle

Expression of γ-glutamyl transpeptidase (GGT) in the developing mouse tooth, intervertebral disc, and hair follicle was investigated in terms of its localization during ontogenic stages and its association or lack of association with cell proliferation (labeled nuclei after [3H]thymidine nijection or metaphase-arrested cells after colchicine injection). The data demonstrate that ( a ) GGT expression followed a program of activity and localization changes that correlated with the progressive emergence of developmental stages and ( b ) GGT activity in developing tissues derived either from epithelium (enamel-producing cells and hair follicle cells) or from mesenchyme (intervertebral disc cells) was localized only in mitotically quiescent cellular layers or regions associated with the production of specialized tissue products; however, not all postmitotic regions expressed GGT activity. Although further research is needed to clarify the role of GGT in normal and neoplastic tissues, we conclude that increasing evidence from this and other laboratories implicates GGT as a marker of cell differentiation, cell aging, and/or reduced cell proliferation.

[1]  G. Kistler,et al.  The activity and distribution of gamma-glutamyl transpeptidase (y-GT) in human lung cancers serially transplanted in nude mice , 1977, Histochemistry.

[2]  V. Potter,et al.  Phenotypic Diversity of γ-Glutamyltranspeptidase Activity and Protein Secretion in Hepatoma Cell Lines , 1982 .

[3]  M. Zeydel,et al.  γ-Glutamyl transpeptidase and glutathione in aging IMR-90 fibroblasts and in differentiating 3T3 L1 preadipocytes , 1982 .

[4]  M. Anderson,et al.  Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[5]  G. Shklar,et al.  Rapid induction of gamma-glutamyl transpeptidase-rich intraepithelial clones in 7,12-dimethylbenz(a)anthracene-treated hamster buccal pouch. , 1982, Cancer research.

[6]  I. Thesleff,et al.  Tissue interactions in tooth development. , 1981, Differentiation; research in biological diversity.

[7]  橋詰 博行.  Three-dimensional architecture and development of lumbar intervertebral discs , 1981 .

[8]  A. Meister.  On the cycles of glutathione metabolism and transport. , 1981, Current topics in cellular regulation.

[9]  S. Eisenstein,et al.  Biochemical changes in intervertebral disc degeneration. , 1981, Biochimica et biophysica acta.

[10]  P. Christner,et al.  Properties of dissociatively extracted fetal tooth matrix proteins. I. Principal molecular species in developing bovine enamel. , 1980, The Journal of biological chemistry.

[11]  T. Taylor,et al.  Distribution of Glycosaminoglycans Across the Normal and the Scoliotic Disc , 1980, Spine.

[12]  K. Sato,et al.  Re-elevation of gamma-glutamyl transpeptidase activity in periportal hepatocytes of rats with age. , 1980, Gan.

[13]  O. Griffith,et al.  The apparent glutathione oxidase activity of gamma-glutamyl transpeptidase. Chemical mechanism. , 1980, The Journal of biological chemistry.

[14]  T. Higashi,et al.  Nutritional significance of increase in gamma-glutamyltransferase in mouse liver before birth. , 1980, The Journal of nutrition.

[15]  H. Pitot.  Characteristics of Stages of Hepatocarcinogenesis , 1980 .

[16]  E. Fiala,et al.  gamma-Glutamyltransferase, a common marker of human epithelial tumors? , 1980, Cancer detection and prevention.

[17]  S. Tate,et al.  Conversion of glutathione to glutathione disulfide, a catalytic function of gamma-glutamyl transpeptidase. , 1979, The Journal of biological chemistry.

[18]  K. Holbrook,et al.  Differentiation markers in fetal epidermis: transglutaminase and transpeptidase. , 1979, Journal of Investigative Dermatology.

[19]  C. E. Smith.  Ameloblasts: Secretory and Resorptive Functions , 1979, Journal of dental research.

[20]  J. Eastoe.  Enamel Protein Chemistry - Past, Present and Future , 1979, Journal of dental research.

[21]  C. P. Leblond,et al.  Dynamics of Enamel Formation in the Rat Incisor Tooth , 1979, Journal of dental research.

[22]  O. Fejerskov.  Human Dentition and Experimental Animals , 1979, Journal of dental research.

[23]  D. Eyre,et al.  Biochemistry of the intervertebral disc. , 1979, International review of connective tissue research.

[24]  H. Pitot,et al.  Fetal phenotypic expression by adult rat hepatocytes on collagen gel/nylon meshes. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[25]  R. Boutwell,et al.  Localization and Significance of γ-Glutamyltranspeptidase in Normal and Neoplastic Mouse Skin , 1978 .

[26]  A. Meister,et al.  Serine-borate complex as a transition-state inhibitor of gamma-glutamyl transpeptidase. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[27]  E. Farber,et al.  Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis. , 1978, Cancer research.

[28]  W. Reutter,et al.  Induction and 'superinduction' of sialylation of membrane-bound gamma-glutamyltransferase during liver regeneration. , 1978, European journal of biochemistry.

[29]  H. Slavkin,et al.  Identification of four extracellular-matrix enamel proteins during embryonic-rabbit tooth-organ development. , 1977, The Biochemical journal.

[30]  T. Kobayasi,et al.  Ultrastructure of prolapsed disc. , 1977, Acta orthopaedica Scandinavica.

[31]  S. Prusiner,et al.  A novel mechanism for group translocation: Substrate‐product reutilization by γ‐glutamyl transpeptidase in peptide and amino acid transport , 1976, Journal of cellular physiology.

[32]  A. Meister,et al.  Subunit structure and isozymic forms of gamma-glutamyl transpeptidase. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[33]  A. Meister,et al.  Membrane-Bound y-Glutamyl Transpeptidase , 1976 .

[34]  V. Desmet,et al.  Histochemistry of gamma-glutamyl transpeptidase in rat liver during aflatoxin B1-induced carcinogenesis. , 1975, Journal of the National Cancer Institute.

[35]  N. Curthoys,et al.  Phosphate-independent glutaminase from rat kidney. Partial purification and identity with gamma-glutamyltranspeptidase. , 1975, The Journal of biological chemistry.

[36]  O. Nome.  Demecolcin and vinblastine sulphate as stathmokinetic agents for different tissues of the hairless mouse. , 1975, Pathologia Europaea.

[37]  A. Meister,et al.  Interaction of gamma-glutamyl transpeptidase with amino acids, dipeptides, and derivatives and analogs of glutathione. , 1974, The Journal of biological chemistry.

[38]  Charles E. Smith,et al.  Morphological classification of rat incisor ameloblasts , 1974, The Anatomical record.

[39]  W. Montagna,et al.  7 – The Pilary Apparatus* , 1974 .

[40]  E. Fiala,et al.  Activation by Chemical Carcinogens of γ-Glutamyl Transpeptidase in Rat and Mouse Liver , 1973 .

[41]  A. Weinstock.  CHAPTER 10 – Matrix Development in Mineralizing Tissues as Shown by Radioautography: Formation of Enamel and Dentin , 1972 .

[42]  E. Reith.  The stages of amelogenesis as observed in molar teeth of young rats. , 1970, Journal of ultrastructure research.

[43]  H. B. Chase,et al.  Early anagen initiated by plucking compared with early spontaneous anagen. , 1969 .

[44]  W. E. Straile.  Possible functions of the external root sheath during growth of the hair follicle. , 1962, The Journal of experimental zoology.

[45]  Junji Hasegawa,et al.  Advances in Biology of Skin , 1961 .

[46]  M. Hay.  The development in vivo and in vitro of the lower incisor and molars of the mouse. , 1961, Archives of oral biology.

[47]  S. Cohn.  Development of the molar teeth in the albino mouse. , 1957, The American journal of anatomy.

[48]  William Montagna,et al.  The Structure and Function of Skin , 1956, The Yale Journal of Biology and Medicine.

[49]  W. A. Gaunt.  The development of enamel and dentine on the molars of the mouse, with an account of the enamel-free areas. , 1956, Acta anatomica.

[50]  A. Peacock,et al.  Observations on the postnatal structure of the intervertebral disc in man. , 1952, Journal of anatomy.

[51]  A. Peacock.  Observations on the prenatal development of the intervertebral disc in man. , 1951, Journal of anatomy.

[52]  H. B. Chase,et al.  Critical Stages of Hair Development and Pigmentation in the Mouse , 1951, Physiological Zoology.