Intestinal permeability defects: is it time to treat?

[1]  C. Abraham,et al.  TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. , 2013, Gastroenterology.

[2]  L. Ursell,et al.  Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor , 2013, Science.

[3]  R. Arsenescu,et al.  Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo‐controlled study , 2013, Alimentary pharmacology & therapeutics.

[4]  M. Camilleri,et al.  Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[5]  W. Petri,et al.  Environmental enteropathy: critical implications of a poorly understood condition. , 2012, Trends in molecular medicine.

[6]  O. Suchowersky,et al.  Increased Intestinal Permeability and Parkinson Disease Patients: Chicken or Egg? , 2012, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[7]  A. Zinsmeister,et al.  Urine sugars for in vivo gut permeability: validation and comparisons in irritable bowel syndrome-diarrhea and controls. , 2011, American journal of physiology. Gastrointestinal and liver physiology.

[8]  A. Del Prete,et al.  Gut microbiota and probiotics in chronic liver diseases. , 2011, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[9]  C. Weber,et al.  Tight junction pore and leak pathways: a dynamic duo. , 2011, Annual review of physiology.

[10]  Carmela Bravaccio,et al.  Alterations of the Intestinal Barrier in Patients With Autism Spectrum Disorders and in Their First-degree Relatives , 2010, Journal of pediatric gastroenterology and nutrition.

[11]  S. Mazmanian,et al.  Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis , 2010, Proceedings of the National Academy of Sciences.

[12]  Christophe Benoist,et al.  Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. , 2010, Immunity.

[13]  S. Milatz,et al.  Claudin-2, a component of the tight junction, forms a paracellular water channel , 2010, Journal of Cell Science.

[14]  A. Garg,et al.  Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritis. , 2010, Gastroenterology.

[15]  C. Weber,et al.  Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity* , 2010, The Journal of Biological Chemistry.

[16]  A. Marchiando,et al.  Epithelial barriers in homeostasis and disease. , 2010, Annual review of pathology.

[17]  Jerrold R. Turner,et al.  Intestinal mucosal barrier function in health and disease , 2009, Nature Reviews Immunology.

[18]  Michael Fromm,et al.  Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance. , 2009, Biophysical journal.

[19]  K. Gradel,et al.  Increased short- and long-term risk of inflammatory bowel disease after salmonella or campylobacter gastroenteritis. , 2009, Gastroenterology.

[20]  C. V. Van Itallie,et al.  Physiology and function of the tight junction. , 2009, Cold Spring Harbor perspectives in biology.

[21]  G. Davidson,et al.  13C-Sucrose Breath Test: Novel Use of a Noninvasive Biomarker of Environmental Gut Health , 2009, Pediatrics.

[22]  K. McCoy,et al.  Host Responses to Intestinal Microbial Antigens in Gluten-Sensitive Mice , 2009, PloS one.

[23]  S. Zeissig,et al.  Epithelial Tight Junctions in Intestinal Inflammation , 2009, Annals of the New York Academy of Sciences.

[24]  Liping Su,et al.  Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. , 2009, Gastroenterology.

[25]  M. Marinaro,et al.  A transient breach in the epithelial barrier leads to regulatory T-cell generation and resistance to experimental colitis. , 2008, Gastroenterology.

[26]  C. Loddenkemper,et al.  Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients , 2008, Gut.

[27]  A. Velcich,et al.  The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria , 2008, Proceedings of the National Academy of Sciences.

[28]  R. Ley,et al.  Innate immunity and intestinal microbiota in the development of Type 1 diabetes , 2008, Nature.

[29]  A. Goebel,et al.  Altered intestinal permeability in patients with primary fibromyalgia and in patients with complex regional pain syndrome. , 2008, Rheumatology.

[30]  A. Keshavarzian,et al.  Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non‐alcoholic steatohepatitis , 2008, Liver international : official journal of the International Association for the Study of the Liver.

[31]  C. McClain,et al.  Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin. , 2008, Journal of hepatology.

[32]  G E Wild,et al.  Predicting relapse in Crohn’s disease: a biopsychosocial model , 2008, Gut.

[33]  C. V. Van Itallie,et al.  The density of small tight junction pores varies among cell types and is increased by expression of claudin-2 , 2008, Journal of Cell Science.

[34]  K. Madsen,et al.  Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse , 2008, Gut.

[35]  J. Johansson,et al.  Gut Toxicity During Hemopoietic Stem Cell Transplantation May Predict Acute Graft-Versus-Host Disease Severity in Patients , 2007, Digestive Diseases and Sciences.

[36]  J. Brenchley,et al.  Microbial translocation is a cause of systemic immune activation in chronic HIV infection , 2006, Retrovirology.

[37]  R. Paroni,et al.  Increased intestinal permeability precedes clinical onset of type 1 diabetes , 2006, Diabetologia.

[38]  J. Meijerink,et al.  Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. , 2006, Gastroenterology.

[39]  R. Spiller,et al.  Abnormal Intestinal Permeability in Subgroups of Diarrhea-Predominant Irritable Bowel Syndromes , 2006, The American Journal of Gastroenterology.

[40]  C. V. Van Itallie,et al.  Claudins and epithelial paracellular transport. , 2006, Annual review of physiology.

[41]  J. Turner,et al.  Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease , 2006, Laboratory Investigation.

[42]  G. Warhurst,et al.  Interferon-γ selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores , 2005, Journal of Cell Science.

[43]  R. Mrsny,et al.  Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. , 2005, The Journal of clinical investigation.

[44]  M. Zeitz,et al.  Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. , 2005, Gastroenterology.

[45]  J. Genschel,et al.  Genetic basis for increased intestinal permeability in families with Crohn’s disease: role of CARD15 3020insC mutation? , 2005, Gut.

[46]  Ronald H. Zielke,et al.  Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[47]  W. Clark,et al.  Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario , 2004, Alimentary pharmacology & therapeutics.

[48]  J. Mwansa,et al.  Responses of small intestinal architecture and function over time to environmental factors in a tropical population. , 2004, The American journal of tropical medicine and hygiene.

[49]  M. Pimentel,et al.  A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing , 2004, Annals of the rheumatic diseases.

[50]  Z. Hijazi,et al.  Intestinal permeability is increased in bronchial asthma , 2004, Archives of Disease in Childhood.

[51]  D. Elliott,et al.  Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease , 2003, American Journal of Gastroenterology.

[52]  B. Scallon,et al.  Validation of the interleukin‐10 knockout mouse model of colitis: antitumour necrosis factor‐antibodies suppress the progression of colitis , 2003, Clinical and experimental immunology.

[53]  T. Borody,et al.  Treatment of Ulcerative Colitis Using Fecal Bacteriotherapy , 2003, Journal of clinical gastroenterology.

[54]  D. Goodenough,et al.  Paracellular ion channel at the tight junction. , 2003, Biophysical journal.

[55]  Torsten Schöneberg,et al.  Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells , 2002, Journal of Cell Science.

[56]  D. Umetsu,et al.  Asthma: an epidemic of dysregulated immunity , 2002, Nature Immunology.

[57]  P. Rutgeerts,et al.  Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease , 2002, American Journal of Gastroenterology.

[58]  D. Brewster,et al.  Small Bowel Intestinal Permeability in Australian Aboriginal Children , 2002, Journal of pediatric gastroenterology and nutrition.

[59]  N. Anstey,et al.  Enteric pathogens, intestinal permeability and nitric oxide production in acute gastroenteritis , 2002, The Pediatric infectious disease journal.

[60]  R. Mrsny,et al.  A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. , 2002, Gastroenterology.

[61]  M Rowland,et al.  Functional modeling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomers. , 2001, American journal of physiology. Cell physiology.

[62]  I. Roberts-Thomson,et al.  The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis , 2001, Gut.

[63]  R. Mrsny,et al.  Noninvasive In vivo Analysis of Human Small Intestinal Paracellular Absorption: Regulation by Na+-Glucose Cotransport , 2000, Digestive Diseases and Sciences.

[64]  T. Risby,et al.  Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis. , 2000, Gastroenterology.

[65]  M. Swain,et al.  Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat. , 2000, Gastroenterology.

[66]  A. Sjöqvist,et al.  Permeability of the rat small intestinal epithelium along the villus-crypt axis: effects of glucose transport. , 2000, Gastroenterology.

[67]  G. Young,et al.  Amylase-resistant starch plus oral rehydration solution for cholera. , 2000, The New England journal of medicine.

[68]  K. Madsen,et al.  Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora. , 1999, Inflammatory bowel diseases.

[69]  G. Corrao,et al.  Intestinal permeability test as a predictor of clinical course in Crohn's disease , 1999, American Journal of Gastroenterology.

[70]  B. Gazzard,et al.  Small intestinal transit, absorption, and permeability in patients with AIDS with and without diarrhoea , 1999, Gut.

[71]  E. Schneeberger,et al.  Rapid reduction of MDCK cell cholesterol by methyl-beta-cyclodextrin alters steady state transepithelial electrical resistance. , 1999, European journal of cell biology.

[72]  A. Elmaagacli,et al.  Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies: final results and long-term follow-up of an open-label prospect , 1999, Blood.

[73]  G. Barclay,et al.  Early increase in intestinal permeability in patients with severe acute pancreatitis: Correlation with endotoxemia, organ failure, and mortality , 1999, Journal of Gastrointestinal Surgery.

[74]  B. Beutler,et al.  Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease. , 1999, Gastroenterology.

[75]  C. Doig,et al.  Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients. , 1998, American journal of respiratory and critical care medicine.

[76]  R. Mrsny,et al.  Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. , 1997, The American journal of physiology.

[77]  G. Oberhuber,et al.  Gastrointestinal permeability in celiac disease. , 1997, Gastroenterology.

[78]  E. O'Loughlin,et al.  Intestinal permeability in kwashiorkor , 1997, Archives of disease in childhood.

[79]  J. Meddings,et al.  Multiple sclerosis patients have peripheral blood CD45RO+ B cells and increased intestinal permeability , 1996, Digestive Diseases and Sciences.

[80]  D. King,et al.  Intestinal permeability and orocaecal transit time in elderly patients with Parkinson's disease. , 1996, Postgraduate medical journal.

[81]  B. Gazzard,et al.  Intestinal absorptive capacity, intestinal permeability and jejunal histology in HIV and their relation to diarrhoea. , 1995, Gut.

[82]  D. Rattner,et al.  Pathogenesis and Prevention of Early Pancreatic Infection in Experimental Acute Necrotizing Pancreatitis , 1995, Annals of surgery.

[83]  R. Hammer,et al.  The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats , 1994, The Journal of experimental medicine.

[84]  J. Cantero-Hinojosa,et al.  Intestinal permeability in patients with ankylosing spondylitis and their healthy relatives. , 1994, British journal of rheumatology.

[85]  H. Lochs,et al.  Intestinal permeability and the prediction of relapse in Crohri's disease , 1993, The Lancet.

[86]  G. May,et al.  Is small intestinal permeability really increased in relatives of patients with Crohn's disease? , 1993, Gastroenterology.

[87]  A. Signore,et al.  NOD mouse colonies around the world--recent facts and figures. , 1993, Immunology today.

[88]  D. Rattner,et al.  Gut macromolecular permeability in pancreatitis correlates with severity of disease in rats. , 1993, Gastroenterology.

[89]  C. Mulder,et al.  Intestinal permeability in patients with coeliac disease and relatives of patients with coeliac disease. , 1993, Gut.

[90]  R. Russell,et al.  Increased intestinal permeability in ankylosing spondylitis--primary lesion or drug effect? , 1991, Gut.

[91]  M. Fink,et al.  Increased intestinal permeability in endotoxic pigs. Mesenteric hypoperfusion as an etiologic factor. , 1991, Archives of surgery.

[92]  D. Levitt,et al.  Physiological measurements of luminal stirring in the dog and human small bowel. , 1990, The Journal of clinical investigation.

[93]  R. Berg,et al.  Effect of hemorrhagic shock on bacterial translocation, intestinal morphology, and intestinal permeability in conventional and antibiotic-decontaminated rats. , 1990, Critical care medicine.

[94]  J. Meddings,et al.  Intestinal glucose transport using perfused rat jejunum in vivo: model analysis and derivation of corrected kinetic constants. , 1989, Clinical science.

[95]  J. Rotter,et al.  Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor. , 1986, Annals of internal medicine.

[96]  J. Madara,et al.  Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: further evidence that the cytoskeleton may influence paracellular permeability and junctional charge selectivity , 1986, The Journal of cell biology.

[97]  R. Heddle,et al.  Increased intestinal permeability in atopic eczema. , 1986, The Journal of investigative dermatology.

[98]  G. Kottra,et al.  Functional properties of the paracellular pathway in some leaky epithelia. , 1983, The Journal of experimental biology.

[99]  J. Madara.  Increases in guinea pig small intestinal transepithelial resistance induced by osmotic loads are accompanied by rapid alterations in absorptive-cell tight-junction structure , 1983, The Journal of cell biology.

[100]  D. Macdonald,et al.  INTESTINAL PERMEABILITY IN PATIENTS WITH ECZEMA AND FOOD ALLERGY , 1981, The Lancet.

[101]  J. Murray,et al.  Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice. , 2008, American journal of physiology. Gastrointestinal and liver physiology.

[102]  H. Buhr,et al.  Glutamine stabilizes intestinal permeability and reduces pancreatic infection in acute experimental pancreatitis , 2006, Journal of Gastrointestinal Surgery.

[103]  A. Keshavarzian,et al.  Leaky gut in alcoholic cirrhosis: a possible mechanism for alcohol-induced liver damage , 1999, American Journal of Gastroenterology.

[104]  J. Hardin,et al.  Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat. , 1999, The American journal of physiology.

[105]  J. Meddings,et al.  Discrimination of site-specific alterations in gastrointestinal permeability in the rat. , 1998, Gastroenterology.

[106]  E. Smecuol,et al.  Gastrointestinal permeability in celiac disease. , 1997, Gastroenterology.

[107]  J. Vossen,et al.  Experimental and clinical gnotobiotics: influence of the microflora on graft-versus-host disease after allogeneic bone marrow transplantation. , 1992, Journal of medicine.

[108]  Heidt Pj,et al.  Experimental and clinical gnotobiotics: influence of the microflora on graft-versus-host disease after allogeneic bone marrow transplantation. , 1992 .

[109]  J. Madara,et al.  Effects of phlorizin and sodium on glucose-elicited alterations of cell junctions in intestinal epithelia. , 1990, The American journal of physiology.

[110]  P. Lunn,et al.  Hypoalbuminemia in energy-malnourished rats infected with Nippostrongylus brasiliensis (Nematoda). , 1988, The Journal of nutrition.