Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis.
暂无分享,去创建一个
D. Stolz | Youhua Liu | Yingjian Li | C. Dai | Dan-ping Wang | Xiaoyue Tan | Yingjian Li
[1] Youhua Liu,et al. Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria. , 2008, The American journal of pathology.
[2] Kebin Hu,et al. Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling. , 2007, The Journal of clinical investigation.
[3] A. Phillips,et al. Inhibition of Integrin-Linked Kinase via a siRNA Expression Plasmid Attenuates Connective Tissue Growth Factor-Induced Human Proximal Tubular Epithelial Cells to Mesenchymal Transition , 2007, American Journal of Nephrology.
[4] H. Itoh,et al. Snail1 is involved in the renal epithelial-mesenchymal transition. , 2007, Biochemical and biophysical research communications.
[5] P. Erne,et al. Integrin‐linked kinase is an essential mediator for T‐cadherin‐dependent signaling via Akt and GSK3β in endothelial cells , 2007 .
[6] Youhua Liu,et al. PINCH-1 promotes tubular epithelial-to-mesenchymal transition by interacting with integrin-linked kinase. , 2007, Journal of the American Society of Nephrology : JASN.
[7] S. Dedhar,et al. Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1. , 2007, Journal of the American Society of Nephrology : JASN.
[8] A. Oloumi,et al. Modulation of Wnt3a-mediated nuclear β-catenin accumulation and activation by integrin-linked kinase in mammalian cells , 2006, Oncogene.
[9] Youhua Liu,et al. Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy. , 2006, Journal of the American Society of Nephrology : JASN.
[10] M. Nieto,et al. Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney , 2006, The EMBO journal.
[11] F. Strutz,et al. Renal fibroblasts and myofibroblasts in chronic kidney disease. , 2006, Journal of the American Society of Nephrology : JASN.
[12] A. Fogo,et al. Plasminogen activator inhibitor-1 in chronic kidney disease: evidence and mechanisms of action. , 2006, Journal of the American Society of Nephrology : JASN.
[13] D. Stolz,et al. Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling. , 2006, Journal of the American Society of Nephrology : JASN.
[14] Matthias Kretzler,et al. Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis. , 2006, Journal of the American Society of Nephrology : JASN.
[15] Youhua Liu,et al. Renal fibrosis: new insights into the pathogenesis and therapeutics. , 2006, Kidney international.
[16] Kebin Hu,et al. Hepatocyte Growth Factor Is a Downstream Effector that Mediates the Antifibrotic Action of Peroxisome Proliferator–Activated Receptor-γ Agonists , 2005 .
[17] G. Mills,et al. Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma , 2005, Molecular Cancer Therapeutics.
[18] Chuanyue Wu. PINCH, N(i)ck and the ILK: network wiring at cell-matrix adhesions. , 2005, Trends in cell biology.
[19] M. Rastaldi,et al. Functional consequences of integrin-linked kinase activation in podocyte damage. , 2005, Kidney international.
[20] Chuanyue Wu. The PINCH-ILK-parvin complexes: assembly, functions and regulation. , 2004, Biochimica et biophysica acta.
[21] R. Kalluri,et al. Epithelial-mesenchymal transition and its implications for fibrosis. , 2003, The Journal of clinical investigation.
[22] D. Lovett,et al. Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation. , 2003, The American journal of pathology.
[23] Junwei Yang,et al. Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice. , 2002, Journal of the American Society of Nephrology : JASN.
[24] Lida Guo,et al. Regulation of fibronectin matrix deposition and cell proliferation by the PINCH‐ILK‐CH‐ILKBP complex , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[25] E. Neilson,et al. Evidence that fibroblasts derive from epithelium during tissue fibrosis. , 2002, The Journal of clinical investigation.
[26] E. Hay,et al. DIRECT EVIDENCE FOR A ROLE OF β‐CATENIN/LEF‐1 SIGNALING PATHWAY IN INDUCTION OF EMT , 2002, Cell biology international.
[27] A. Woods,et al. The distribution and regulation of integrin-linked kinase in normal and diabetic kidneys. , 2001, The American journal of pathology.
[28] Junwei Yang,et al. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. , 2001, The American journal of pathology.
[29] R. Wanke,et al. Integrin linked kinase as a candidate downstream effector in proteinuria , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[30] S. Dedhar,et al. Regulation of Protein Kinase B/Akt-Serine 473 Phosphorylation by Integrin-linked Kinase , 2001, The Journal of Biological Chemistry.
[31] C. Sutherland,et al. Ca2+-independent Smooth Muscle Contraction , 2001, The Journal of Biological Chemistry.
[32] A. Eddy. Molecular basis of renal fibrosis , 2000, Pediatric Nephrology.
[33] S. Dedhar,et al. The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9) , 2000, Oncogene.
[34] L. Donehower,et al. The Integrin-linked Kinase Regulates the Cyclin D1 Gene through Glycogen Synthase Kinase 3β and cAMP-responsive Element-binding Protein-dependent Pathways* , 2000, The Journal of Biological Chemistry.
[35] Y. Tu,et al. The LIM-Only Protein PINCH Directly Interacts with Integrin-Linked Kinase and Is Recruited to Integrin-Rich Sites in Spreading Cells , 1999, Molecular and Cellular Biology.
[36] J. Woodgett,et al. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[37] S. Dedhar,et al. Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity* , 1998, The Journal of Biological Chemistry.
[38] S. Dedhar,et al. Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase , 1996, Nature.
[39] P. Erne,et al. Integrin-linked kinase is an essential mediator for T-cadherin-dependent signaling via Akt and GSK3beta in endothelial cells. , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[40] K. Legate,et al. ILK, PINCH and parvin: the tIPP of integrin signalling , 2006, Nature Reviews Molecular Cell Biology.
[41] S. Dedhar,et al. Integrin-linked kinase: a cancer therapeutic target unique among its ILK , 2005, Nature Reviews Cancer.
[42] Youhua Liu. Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. , 2004, Journal of the American Society of Nephrology : JASN.
[43] Junwei Yang,et al. Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. , 2003, The Journal of clinical investigation.
[44] Junwei Yang,et al. Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. , 2002, Journal of the American Society of Nephrology : JASN.
[45] C. Sutherland,et al. Ca-independent Smooth Muscle Contraction A NOVEL FUNCTION FOR INTEGRIN-LINKED KINASE* , 2001 .