Silymarin suppress CD4+ T cell activation and proliferation: effects on NF-kappaB activity and IL-2 production.

[1]  Jang-Gi Choi,et al.  Anti-inflammatory mechanisms of resveratrol in activated HMC-1 cells: pivotal roles of NF-kappaB and MAPK. , 2009, Pharmacological research.

[2]  R. Agarwal,et al.  Multitargeted therapy of cancer by silymarin. , 2008, Cancer letters.

[3]  M. Gharagozloo,et al.  The effect of an iron (III) chelator, silybin, on the proliferation and cell cycle of Jurkat cells: a comparison with desferrioxamine. , 2008, European journal of pharmacology.

[4]  C. Bortner,et al.  Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentration. , 2007, Human reproduction.

[5]  S. Polyak,et al.  Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin. , 2007, Gastroenterology.

[6]  M. Gharagozloo,et al.  Effects of silymarin on the spontaneous proliferation and cell cycle of human peripheral blood leukemia T cells , 2007, Journal of Cancer Research and Clinical Oncology.

[7]  Carlo Riccardi,et al.  Analysis of apoptosis by propidium iodide staining and flow cytometry , 2006, Nature Protocols.

[8]  M. Gharagozloo,et al.  Effects of silymarin on the proliferation and glutathione levels of peripheral blood mononuclear cells from beta-thalassemia major patients. , 2006, International immunopharmacology.

[9]  V. Křen,et al.  Silybin and silymarin--new effects and applications. , 2005, Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.

[10]  M. Schmitz,et al.  Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to , 2004, The Journal of biological chemistry.

[11]  S. Bacher,et al.  NF‐ĸB activation pathways induced by T cell costimulation , 2003 .

[12]  A. Vollmar,et al.  Silibinin protects mice from T cell-dependent liver injury. , 2003, Journal of hepatology.

[13]  S. Kittur,et al.  Immunostimulatory effect of Silybum Marianum (milk thistle) extract. , 2002, Medical science monitor : international medical journal of experimental and clinical research.

[14]  S. Ansorge,et al.  Thiol-inducing and immunoregulatory effects of flavonoids in peripheral blood mononuclear cells from patients with end-stage diabetic nephropathy. , 2002, Free radical biology & medicine.

[15]  C. Riccardi,et al.  Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB. , 2001, Blood.

[16]  E. Crespo,et al.  Effects of Silymarin on the Acute Stage of the Trinitrobenzenesulphonic Acid Model of Rat Colitis , 2001, Planta medica.

[17]  E. Middleton,et al.  The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. , 2000, Pharmacological reviews.

[18]  H. Farghali,et al.  Silymarin effects on intracellular calcuim and cytotoxicity: a study in perfused rat hepatocytes after oxidative stress injury. , 2000, Pharmacological research.

[19]  S. Manna,et al.  Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis. , 1999, Journal of immunology.

[20]  H. Sakurai,et al.  IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain* , 1999, The Journal of Biological Chemistry.

[21]  Chyung-Ru Wang,et al.  Helper T cell differentiation is controlled by the cell cycle. , 1998, Immunity.

[22]  J. Leiden,et al.  LKLF: A transcriptional regulator of single-positive T cell quiescence and survival. , 1997, Science.

[23]  D. Green,et al.  Fas-ligand: privilege and peril. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[24]  E. Harhaj,et al.  Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-kappaB/Rel transcription factors , 1997, Molecular and cellular biology.

[25]  P. Krammer,et al.  Autocrine T-cell suicide mediated by APO-1/(Fas/CD95) , 1995, Nature.

[26]  J. Roberts,et al.  Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes , 1994, Molecular and cellular biology.

[27]  E. Bosisio,et al.  Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes. , 1992, Pharmacological research.

[28]  K. Nékám,et al.  Immunomodulatory and hepatoprotective effects of in vivo treatment with free radical scavengers. , 1990, The Italian journal of gastroenterology.

[29]  G. Crabtree Contingent genetic regulatory events in T lymphocyte activation. , 1989, Science.

[30]  R. Saller,et al.  The Use of Silymarin in the Treatment of Liver Diseases , 2012, Drugs.

[31]  Raghubir P. Sharma,et al.  Physiological responses of a natural antioxidant flavonoid mixture, silymarin, in BALB/c mice: III. Silymarin inhibits T-lymphocyte function at low doses but stimulates inflammatory processes at high doses. , 2003, Planta medica.

[32]  A. Valenzuela,et al.  Biochemical bases of the pharmacological action of the flavonoid silymarin and of its structural isomer silibinin. , 1994, Biological research.

[33]  S. Schreiber,et al.  The mechanism of action of cyclosporin A and FK506. , 1992, Immunology today.

[34]  P. Meroni,et al.  Silybin inhibition of human T-lymphocyte activation. , 1988, International journal of tissue reactions.