Effect of aging on the monochromatic aberrations of the human eye.

We measured the contrast sensitivity (CS) of a group of older subjects through natural pupils and compared the results with those from a group of younger subjects. We also measured each subject's monochromatic ocular wave-front aberrations using a crossed-cylinder aberroscope and calculated their modulation transfer functions (MTF's) and root-mean-squared (RMS) wave-front aberrations for fixed pupil diameters of 4 mm and 6 mm and for a natural pupil diameter. The CS at a natural pupil diameter and the MTF computed for a fixed pupil diameter were found to be significantly poorer for the older group than for the younger group. However, the older group showed very similar MTF's and significantly smaller RMS wave-front aberrations compared with the younger group at their natural pupil diameters, owing to the effects of age-related miosis. These results suggest that although monochromatic ocular wave-front aberrations for a given pupil size increase with age, the reduction in CS with age is not due to this increase.

[1]  Melanie C. W. Campbell,et al.  Psychophysical measurement of the blur on the retina due to optical aberrations of the eye , 1990, Vision Research.

[2]  David A. Atchison,et al.  Measurement of monochromatic ocular aberrations of human eyes as a function of accommodation by the howland aberroscope technique , 1995, Vision Research.

[3]  W N Charman,et al.  Wavefront aberration of the eye: a review. , 1991, Optometry and vision science : official publication of the American Academy of Optometry.

[4]  P Artal,et al.  Effects of aging in retinal image quality. , 1993, Journal of the Optical Society of America. A, Optics and image science.

[5]  R. Sekuler,et al.  Role of the crystalline lens in the spatial vision loss of the elderly. , 1985, Investigative ophthalmology & visual science.

[6]  D B Elliott,et al.  CONTRAST SENSITIVITY DECLINE WITH AGEING: A NEURAL OR OPTICAL PHENOMENON? * , 1987, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[7]  I Iglesias,et al.  Reconstruction of the point-spread function of the human eye from two double-pass retinal images by phase-retrieval algorithms. , 1998, Journal of the Optical Society of America. A, Optics, image science, and vision.

[8]  M. Bullimore,et al.  A New Test for the Evaluation of Disability Glare , 1991, Optometry and vision science : official publication of the American Academy of Optometry.

[9]  H. H. Hopkins.  The Application of Frequency Response Techniques in Optics , 1962 .

[10]  R. Sekuler,et al.  Contrast sensitivity throughout adulthood , 1982, Vision Research.

[11]  David Whitaker,et al.  Neural contribution to spatiotemporal contrast sensitivity decline in healthy ageing eyes , 1990, Vision Research.

[12]  W. Charman,et al.  MEASUREMENT OF THE AXIAL WAVEFRONT ABERRATION OF THE HUMAN EYE , 1985, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[13]  R. Hemenger,et al.  Intraocular light scatter in normal vision loss with age. , 1984, Applied optics.

[14]  I Iglesias,et al.  Estimates of the ocular wave aberration from pairs of double-pass retinal images. , 1998, Journal of the Optical Society of America. A, Optics, image science, and vision.

[15]  R Navarro,et al.  Monochromatic aberrations and point-spread functions of the human eye across the visual field. , 1998, Journal of the Optical Society of America. A, Optics, image science, and vision.

[16]  B. Howland,et al.  A subjective method for the measurement of monochromatic aberrations of the eye. , 1977, Journal of the Optical Society of America.

[17]  B. Howland,et al.  Subjective measurement of high-order aberrations of the eye. , 1976, Science.

[18]  I Iglesias,et al.  Double-pass measurements of the retinal-image quality with unequal entrance and exit pupil sizes and the reversibility of the eye's optical system. , 1995, Journal of the Optical Society of America. A, Optics, image science, and vision.

[19]  The Charles F. Prentice Award Lecture 1990: specific tests and specific blindnesses: keys, locks, and parallel processing. , 1991, Optometry and vision science : official publication of the American Academy of Optometry.

[20]  W N Charman,et al.  Objective technique for the determination of monochromatic aberrations of the human eye. , 1984, Journal of the Optical Society of America. A, Optics and image science.

[21]  Junzhong Liang,et al.  Aberrations and retinal image quality of the normal human eye. , 1997, Journal of the Optical Society of America. A, Optics, image science, and vision.

[22]  Junzhong Liang,et al.  Objective measurement of wave aberrations of the human eye with the use of a Hartmann-Shack wave-front sensor. , 1994, Journal of the Optical Society of America. A, Optics, image science, and vision.

[23]  H C Howland,et al.  Generation of third-order spherical and coma aberrations by use of radically symmetrical fourth-order lenses. , 1998, Journal of the Optical Society of America. A, Optics, image science, and vision.

[24]  M J Cox,et al.  A new computerised video-aberroscope for the determination of the aberration of the human eye. , 1995, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[25]  C. McGrath,et al.  Assessment of the optical contributions to the age-related deterioration in vision. , 1985, Quarterly journal of experimental physiology.

[26]  P. D. Spear,et al.  Neural bases of visual deficits during aging , 1993, Vision Research.

[27]  Denis G. Pelli,et al.  Accurate control of contrast on microcomputer displays , 1991, Vision Research.

[28]  A Bradley,et al.  Comparison of the eye's wave-front aberration measured psychophysically and with the Shack-Hartmann wave-front sensor. , 1998, Journal of the Optical Society of America. A, Optics, image science, and vision.

[29]  R. Applegate,et al.  The crossed-cylinder aberroscope: an alternative method of calculation of the aberrations. , 1996, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[30]  R A Applegate,et al.  Assessment of the accuracy of the crossed-cylinder aberroscope technique. , 1998, Journal of the Optical Society of America. A, Optics, image science, and vision.

[31]  T. J. T. P. van den Berg,et al.  The intraocular straylight function in 129 healthy volunteers; Dependence on angle, age and pigmentation , 1990, Vision Research.

[32]  Cynthia Owsley,et al.  Aging and neural spatial contrast sensitivity: Photopic vision , 1993, Vision Research.

[33]  J. Rovamo,et al.  The effects of grating area and spatial frequency on contrast sensitivity as a function of light level , 1993, Vision Research.

[34]  S A Burns,et al.  Measurement of the wave-front aberration of the eye by a fast psychophysical procedure. , 1998, Journal of the Optical Society of America. A, Optics, image science, and vision.

[35]  D. Whitaker,et al.  Factors affecting light-adapted pupil size in normal human subjects. , 1994, Investigative ophthalmology & visual science.

[36]  M. Cox,et al.  Reliability and Validity Studies of a New Computer-Assisted Crossed-Cylinder Aberroscope , 1997, Optometry and vision science : official publication of the American Academy of Optometry.