论文信息 - Experimental study of the potential for contact sensitization and cross‐reaction of imidazole antifungals

Experimental study of the potential for contact sensitization and cross‐reaction of imidazole antifungals

We examined the potential for contact sensitization of miconazole nitrate and croconazole hydro‐chloride and the cross‐reaction between them in guinea pigs by the maximization lest of Mugnsson and Kligman. Contact sensitivity was induced by croconazole hydrochloride in 5 out of 7 animals which, after being injected with 5% croconazole hydrochloride, underwent a closed patch with 25% croconazole hydrochloride. Contact sensitivity was not induced by miconazole nitrate. The 5 animals sensitized to croconazole hydrochloride were tested with 8 other imidazole antifungals and positive reactions were observed to oxiconazole nitrate in 2 of the 5 animals. This response may be a cross‐reaction.

C. Asagami | K. Nishioka | Keiko Kukata

[1] B. Hausen,et al. Studies on the Sensitizing Capacity of Imidazole Derivatives , 1990 .

[2] R. Sugimoto,et al. Allergic contact dermatitis from croconazole hydrochloride , 1989, Contact dermatitis.

[3] D. Tennstedt,et al. Contact dermatitis from topical imidazole antifungals: 15 new cases , 1989, Contact dermatitis.

[4] R. Happle,et al. Contact allergy to miconazole , 1988, Contact dermatitis.

[5] P. Frosch,et al. Contact allergy to imidazole antimycotics , 1988, Contact dermatitis.

[6] E. Hecke,et al. Contact sensitivity to enilconazole , 1983 .

[7] E. van Hecke,et al. Contact sensitivity to enilconazole. , 1983, Contact dermatitis.

[8] E. Hecke,et al. Contact sensitivity to imidazole derivatives , 1981 .

[9] E. van Hecke,et al. Contact sensitivity to imidazole derivatives. , 1981, Contact dermatitis.

[10] P. Spiekermann,et al. Clinical evaluation of clotrimazole. A broad-spectrum antifungal agent. , 1976, Archives of dermatology.

[11] CLINICAL EVALUATION OF CLOTRIMAZOLE , 1976 .

[12] A M Kligman,et al. The identification of contact allergens by animal assay. The guinea pig maximization test. , 1970, The Journal of investigative dermatology.