THE HYPOPHYSEAL GONADOTROPIC HORMONES

The discovery in 1926-1927 that the anterior pituitary gland secreted a substance essential to the functioning of the gonads has been followed by many investigations, which have greatly extended the knowledge of the pituitary-gonad interrelationship. I do not wish to give the impression that important work in this field had not been done prior to 1926-1927. The observations published here and abroad at that time were only a final demonstration of the important role played by the anterior hypophysis in reproduction. More than twenty years ago dishing and his co-workers1and Aschner2had demonstrated that hypophysectomy caused an atrophy of the reproductive system. By partial gonadectomies, parabioses and the like it had also been shown that some extragonadal factor was essential to gonadal function. Evans and Long3had secured excessive luteinization of the ovaries in normal rats by the injection of anterior lobe extracts.

[1]  H. H. Cole,et al.  Concerning Gonadotropic Substances in Mare Serum , 1934 .

[2]  F. Hisaw,et al.  INTERACTIONS OF GONAD STIMULATING HORMONES IN OVARIAN DEVELOPMENT , 1934 .

[3]  H. Evans,et al.  Maintenance and repair of the reproductive system of hypophysectomized male rats by hypophyseal synergist, pregnancy-prolan and combinations thereof , 1934 .

[4]  H. Evans,et al.  THE REPAIR OF THE REPRODUCTIVE SYSTEM OF HYPOPHYSECTOMIZED FEMALE RATS BY COMBINATIONS OF AN HYPOPHYSEAL EXTRACT (SYNERGIST) WITH PREGNANCY-PROLAN , 1934 .

[5]  H. Evans,et al.  ON A SELECTIVE GAMETOGENIC EFFECT OF CERTAIN HYPOPHYSEAL EXTRACTS. , 1934, Science.

[6]  E. Engle,et al.  Gonad-stimulating hormones from the pituitary and from human urine* , 1934 .

[7]  E. Engle.  LUTEINIZATION OF THE OVARY OF THE MONKEY BY MEANS OF COMBINED USE OF ANTERIOR PITUITARY EXTRACT AND AN EXTRACT OF PREGNANCY URINE , 1934 .

[8]  Zonja Wallen-Lawrence.  PROOF OF THE EXISTENCE OF A FOLLICLE-STIMULATING AND A LUTEINIZING HORMONE IN THE ANTERIOR LOBE OF THE PITUITARY BODY , 1934 .

[9]  S. Leonard.  A STUDY OF THE PITUITARY FACTOR INCREASING THE OVARIAN WEIGHTS OF IMMATURE RATS WHEN INJECTED IN COMBINATION WITH PREGNANCY URINE , 1934 .

[10]  P. E. Smith,et al.  THE HYPOPHYSEAL-LIKE QUALITIES OF THE GONADOTROPIC PRINCIPLE FOUND IN THE URINE OF CERTAIN INDIVIDUALS , 1934 .

[11]  E. Engle,et al.  Gametokinetic Action of Extracts of Follicle-Stimulating Urine. ∗ , 1934 .

[12]  S. Leonard,et al.  Responses of the reproductive system of hypophysectomized rats to injections of pregnancy‐urine extracts. II. The female , 1934 .

[13]  S. Leonard,et al.  Responses of the reproductive system of hypophysectomized and normal rats to injections of pregnancy‐urine extracts. I. The male , 1934 .

[14]  W. L. Brosius,et al.  SPERMATOGENESIS FOLLOWING THERAPY WITH THE GONAD STIMULATING EXTRACT FROM THE URINE OF PREGNANCY , 1933 .

[15]  S. H. Geist.  Reaction of the mature human ovary to antuitrin-s , 1933 .

[16]  H. Selye,et al.  ON THE EFFECT OF THE ANTERIOR PITUITARY-LIKE HORMONE ON THE OVARY OF THE HYPOPHYSECTOMIZED RAT , 1933 .

[17]  R. Hertz,et al.  SEX HORMONES OF THE ANTERIOR LOBE OF THE HYPOPHYSIS: Further Purification of a Follicular Stimulating Factor and the Physiological Effects on Immature Rats and Rabbits , 1933 .

[18]  P. R. Austin,et al.  THE HYPOPHYSEAL SUBSTANCE GIVING INCREASED GONADOTROPIC EFFECTS WHEN COMBINED WITH PROLAN , 1933, The Journal of experimental medicine.

[19]  A. Hellbaum.  Gonadotropic Activity of the Pituitaries of Horses.∗ , 1933 .

[20]  J. Browne.  THE CHEMICAL AND PHYSIOLOGICAL PROPERTIES OF CRYSTALLINE OESTROGENIC HORMONES , 1933 .

[21]  H. H. Cole,et al.  THE POTENCY OF BLOOD SERUM OF MARES IN PROGRESSIVE STAGES OF PREGNANCY IN EFFECTING THE SEXUAL MATURITY OF THE IMMATURE RAT , 1930 .

[22]  E. Engle,et al.  Experimental evidence regarding the rôle of the anterior pituitary in the development and regulation of the genital system , 1927 .

[23]  Philip E. Smith,et al.  THE DISABILITIES CAUSED BY HYPOPHYSECTOMY AND THEIR REPAIR: THE TUBERAL (HYPOTHALAMIC) SYNDROME IN THE RAT , 1927 .

[24]  Philip E. Smith,et al.  Hastening Development of Female Genital System by Daily Homoplastic Pituitary Transplants. , 1926 .

[25]  H. Evans,et al.  Characteristic Effects upon Growth, Oestrus and Ovulation Induced by the Intraperitoneal Administration of Fresh Anterior Hypophyseal Substance. , 1922, Proceedings of the National Academy of Sciences of the United States of America.

[26]  K. Meyer,et al.  The Growth And Gonad-Stimulating Hormones Of The Anterior Hypophysis , 1933 .