Serum, salivary and tissue proteomics for discovery of biomarkers for head and neck cancers

Initial clinically oriented applications of emerging proteomic technologies that aim to identify biomarkers for head and neck squamous cell carcinoma diagnostics have yielded promising results. The development of new proteomic diagnostics remains critical for the early detection of head and neck squamous cell carcinoma at more treatable stages. Prognostic markers for disease recurrence and treatment sensitivities are also required. In this overview of current biomarker identification strategies for head and neck squamous cell carcinoma, different combinations of mass spectrometry platforms, laser capture microscopy and 2D gel electrophoresis procedures are summarized as applied to readily available clinical specimens (tissue, blood and saliva). Issues related to assay reproducibility, management of large data sets and future improvements in clinical proteomics are also addressed.

[1]  Rui Vitorino,et al.  Identification of human whole saliva protein components using proteomics , 2004, Proteomics.

[2]  Thomas P Conrads,et al.  SELDI-TOF MS for diagnostic proteomics. , 2003, Analytical chemistry.

[3]  R. Irizarry,et al.  Serum protein MALDI profiling to distinguish upper aerodigestive tract cancer patients from control subjects. , 2003, Journal of the National Cancer Institute.

[4]  V. Patel,et al.  New approaches to the understanding of the molecular basis of oral cancer. , 2001, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

[5]  Emanuel F Petricoin,et al.  Lessons from Kitty Hawk: From feasibility to routine clinical use for the field of proteomic pattern diagnostics , 2004, Proteomics.

[6]  E. Petricoin,et al.  Use of proteomic patterns in serum to identify ovarian cancer , 2002, The Lancet.

[7]  H. Davies,et al.  Tissue-specific microdissection coupled with ProteinChip array technologies: applications in cancer research. , 2000, BioTechniques.

[8]  G. Wright,et al.  Development of a novel proteomic approach for the detection of transitional cell carcinoma of the bladder in urine. , 2001, The American journal of pathology.

[9]  William E Grizzle,et al.  Serum levels of an isoform of apolipoprotein A-II as a potential marker for prostate cancer. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[10]  Qing‐Yu He,et al.  Proteomics of buccal squamous cell carcinoma: The involvement of multiple pathways in tumorigenesis , 2004, Proteomics.

[11]  E. Speel,et al.  Role of human papillomavirus in the development of head and neck squamous cell carcinomas , 2004, Acta oto-laryngologica.

[12]  E. Rehberg,et al.  Guanylin and functional coupling proteins in the human salivary glands and gland tumors : expression, cellular localization, and target membrane domains. , 2002, The American journal of pathology.

[13]  D. Chan,et al.  Proteomics and bioinformatics approaches for identification of serum biomarkers to detect breast cancer. , 2002, Clinical chemistry.

[14]  M E Belov,et al.  High-throughput proteomics using high-efficiency multiple-capillary liquid chromatography with on-line high-performance ESI FTICR mass spectrometry. , 2001, Analytical chemistry.

[15]  L. Kowalski,et al.  Nodal metastases: predictive factors. , 1998, Otolaryngologic clinics of North America.

[16]  E. Petricoin,et al.  Laser Capture Microdissection , 1996, Science.

[17]  D. Chan,et al.  Bioinformatics strategies for proteomic profiling. , 2004, Clinical biochemistry.

[18]  K. Baggerly,et al.  Pharmacoproteomic analysis of prechemotherapy and postchemotherapy plasma samples from patients receiving neoadjuvant or adjuvant chemotherapy for breast carcinoma , 2004, Cancer.

[19]  D. Sidransky,et al.  Molecular detection approaches for smoking associated tumors , 2002, Oncogene.

[20]  P. Schellhammer,et al.  Serum protein fingerprinting coupled with a pattern-matching algorithm distinguishes prostate cancer from benign prostate hyperplasia and healthy men. , 2002, Cancer research.

[21]  Ruedi Aebersold,et al.  Proteome analysis of low-abundance proteins using multidimensional chromatography and isotope-coded affinity tags. , 2002, Journal of proteome research.

[22]  V. Lokeshwar,et al.  Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors , 2003, International journal of cancer.

[23]  B. Ghafouri,et al.  Mapping of proteins in human saliva using two‐dimensional gel electrophoresis and peptide mass fingerprinting , 2003, Proteomics.

[24]  Emanuel F. Petricoin,et al.  Biomarker Amplification by Serum Carrier Protein Binding , 2004, Disease markers.

[25]  Carlo Montemagno,et al.  Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. , 2004, Archives of otolaryngology--head & neck surgery.

[26]  J Silvio Gutkind,et al.  Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays , 2000, Oncogene.

[27]  Jeffrey S. Morris,et al.  Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments , 2004, Bioinform..

[28]  Qing‐Yu He,et al.  Identification of tumor‐associated proteins in oral tongue squamous cell carcinoma by proteomics , 2004, Proteomics.

[29]  O John Semmes,et al.  Serum Protein Profiles to Identify Head and Neck Cancer , 2004, Clinical Cancer Research.

[30]  Li Mao,et al.  Identification and validation of metastasis-associated proteins in head and neck cancer cell lines by two-dimensional electrophoresis and mass spectrometry , 2004, Clinical & Experimental Metastasis.

[31]  G D Schuler,et al.  Molecular profiling of clinical tissues specimens: feasibility and applications. , 2000, The Journal of molecular diagnostics : JMD.

[32]  Nan Hu,et al.  2D Differential In-gel Electrophoresis for the Identification of Esophageal Scans Cell Cancer-specific Protein Markers* , 2002, Molecular & Cellular Proteomics.

[33]  F. von Eggeling,et al.  Biomarker Discovery and Identification in Laser Microdissected Head and Neck Squamous Cell Carcinoma with ProteinChip® Technology, Two-dimensional Gel Electrophoresis, Tandem Mass Spectrometry, and Immunohistochemistry* , 2003, Molecular & Cellular Proteomics.

[34]  S. Humphrey,et al.  A review of saliva: normal composition, flow, and function. , 2001, The Journal of prosthetic dentistry.

[35]  S. Wiseman,et al.  The role of genomic instability in the pathogenesis of squamous cell carcinoma of the head and neck. , 2004, Surgical oncology clinics of North America.

[36]  P. Schellhammer,et al.  Boosted decision tree analysis of surface-enhanced laser desorption/ionization mass spectral serum profiles discriminates prostate cancer from noncancer patients. , 2002, Clinical chemistry.

[37]  E. Diamandis.  Mass Spectrometry as a Diagnostic and a Cancer Biomarker Discovery Tool , 2004, Molecular & Cellular Proteomics.

[38]  Günther Ernst,et al.  A Technical Triade for Proteomic Identification and Characterization of Cancer Biomarkers , 2004, Cancer Research.

[39]  J. Potter,et al.  A data-analytic strategy for protein biomarker discovery: profiling of high-dimensional proteomic data for cancer detection. , 2003, Biostatistics.

[40]  Paola Pisani,et al.  Estimates of the world‐wide prevalence of cancer for 25 sites in the adult population , 2002, International journal of cancer.

[41]  E. Petricoin,et al.  Proteomic analysis of laser capture microdissected human prostate cancer and in vitro prostate cell lines , 2000, Electrophoresis.

[42]  K A Baggerly,et al.  Pharmacoproteomic analysis of pre-and post-chemotherapy plasma samples from patients receiving neoadjuvant or adjuvant chemotherapy for breast cancer. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[43]  G D Schuler,et al.  Molecular profiling of clinical tissue specimens: feasibility and applications. , 2000, The American journal of pathology.

[44]  D. Malamud,et al.  Saliva as a diagnostic fluid. , 1992, BMJ.

[45]  George L. Wright,et al.  SELDI proteinchip MS: a platform for biomarker discovery and cancer diagnosis. , 2002, Expert review of molecular diagnostics.

[46]  O. John Semmes,et al.  SELDI-TOF Serum Profiling for Prognostic and Diagnostic Classification of Breast Cancers , 2004, Disease markers.

[47]  Patrick C. Walsh,et al.  American Cancer Society Guidelines for the Early Detection of Cancer , 2002, CA: a cancer journal for clinicians.

[48]  B. Adam,et al.  Identification of patients with head and neck cancer using serum protein profiles. , 2004, Archives of otolaryngology--head & neck surgery.

[49]  E. Gabrielson,et al.  Multiple head and neck tumors: evidence for a common clonal origin. , 1996, Cancer research.