Numeric Aberration of Chromosome 17 Is Strongly Correlated with p53 Overexpression, Tumor Proliferation and Histopathology in Human Bladder Cancer

Background This study investigated the relationships between the numeric aberrations of chromosome 17 and p53 expression, the proliferating cell nuclear antigen labeling index (PCNA‐LI) and histopathology, to determine their prognostic significance in bladder cancer.

[1]  T C Gasser,et al.  Heterogeneity of chromosome 17 and erbB-2 gene copy number in primary and metastatic bladder cancer. , 1995, Cytometry.

[2]  M. Harada,et al.  Numerical chromosome aberrations in bladder cancer detected by in situ hybridization. , 1995, British journal of urology.

[3]  L. Looijenga,et al.  p53 immunohistochemistry as an independent prognostic factor for superficial transitional cell carcinoma of the bladder. , 1995, British Journal of Cancer.

[4]  A. Sandberg,et al.  Review of chromosome studies in urological tumors. II. Cytogenetics and molecular genetics of bladder cancer. , 1994, The Journal of urology.

[5]  S. Groshen,et al.  p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer. , 1993, The American journal of pathology.

[6]  J. Underwood.  Diagnostic Molecular Pathology. A Practical Approach , 1993 .

[7]  D. Lane,et al.  p53, guardian of the genome , 1992, Nature.

[8]  W. Isaacs,et al.  Molecular biology of bladder cancer. , 1992, Hematology/oncology clinics of North America.

[9]  S. Maeda,et al.  Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas. , 1991, Cancer research.

[10]  B H Mayall,et al.  Centromeric copy number of chromosome 7 is strongly correlated with tumor grade and labeling index in human bladder cancer. , 1991, Cancer research.

[11]  F. Ramaekers,et al.  Numerical chromosome 1, 7, 9, and 11 aberrations in bladder cancer detected by in situ hybridization. , 1991, Cancer research.

[12]  P. Nichols,et al.  Allelic loss of chromosome 17p distinguishes high grade from low grade transitional cell carcinomas of the bladder. , 1990, Cancer research.

[13]  B. Vogelstein,et al.  A genetic model for colorectal tumorigenesis , 1990, Cell.

[14]  J W Gray,et al.  Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[15]  H. Wijkström,et al.  Flow cytometric DNA and cytogenetic studies in human tumors: a comparison and discussion of the differences in modal values obtained by the two methods. , 1986, Cytometry.

[16]  S. Hsu,et al.  Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. , 1981, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.