Alterations in the humoral immune response and tumor frequencies in mice exposed to benzo[a]pyrene and X-rays before or after birth.

Pregnant mice were given one of three treatment regimens during mid (11 to 13 d) or late (16 to 18 d) gestation: benzo[a]pyrene (BaP) (150 μg/g body weight), 150 R X‐irradiation, or X‐irradiation + BaP. A group of virgin mice were injected with BaP after birth (at 1 wk or 16 wk) with doses similar to or higher than those to which progeny of pregnant mice were exposed in utero. The offspring exposed during fetal life showed a marked suppression in anti‐SRBC plaque‐forming cells (PFC) 1 wk after birth (pups), followed by an apparent recovery at 4 wk. Return to the immuno‐suppressed state seen in pups was most noticeable in adults encountering BaP alone during gestation. In this group, increased tumor incidence was associated with a sustained reduction in PFC response. In contrast, after fetal exposure to X‐rays or injection with BaP postnatally, immune competence was not appreciably different from normal in late life and tumor incidence was only slightly higher than controls with X‐rays or a high dose (150 ...

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