Spatiotemporal Characteristics of QRS Complexes Enable the Diagnosis of Brugada Syndrome Regardless of the Appearance of a Type 1 ECG

The diagnosis of Brugada syndrome based on the ECG is hampered by the dynamic nature of its ECG manifestations. Brugada syndrome patients are only 25% likely to present a type 1 ECG. The objective of this study is to provide an ECG diagnostic criterion for Brugada syndrome patients that can be applied consistently even in the absence of a type 1 ECG.

[1]  A. Sittig,et al.  Reconstruction of the Frank vectorcardiogram from standard electrocardiographic leads: diagnostic comparison of different methods. , 1990, European heart journal.

[2]  J. Brugada,et al.  Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. , 1992, Journal of the American College of Cardiology.

[3]  Rangachar Kasturi,et al.  Machine vision , 1995 .

[4]  C. Antzelevitch,et al.  Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. , 1999, Circulation.

[5]  C. Antzelevitch The Brugada Syndrome: Ionic Basis and Arrhythmia Mechanisms , 2001, Journal of cardiovascular electrophysiology.

[6]  W. Shimizu,et al.  The electrophysiologic mechanism of ST-segment elevation in Brugada syndrome. , 2002, Journal of the American College of Cardiology.

[7]  Wataru Shimizu,et al.  Brugada syndrome: report of the second consensus conference. , 2005, Heart rhythm.

[8]  P. Brugada,et al.  Brugada syndrome: From cell to bedside , 2001 .

[9]  Ruben Coronel,et al.  Slow and Discontinuous Conduction Conspire in Brugada Syndrome: A Right Ventricular Mapping and Stimulation Study , 2008, Circulation. Arrhythmia and electrophysiology.

[10]  H. Morita,et al.  Repolarization heterogeneity in the right ventricular outflow tract: correlation with ventricular arrhythmias in Brugada patients and in an in vitro canine Brugada model. , 2008, Heart Rhythm.

[11]  H. Morita,et al.  Longer repolarization in the epicardium at the right ventricular outflow tract causes type 1 electrocardiogram in patients with Brugada syndrome. , 2008, Journal of the American College of Cardiology.

[12]  J. Brugada,et al.  Variability of the Diagnostic ECG Pattern in an ICD Patient Population with Brugada Syndrome , 2009, Journal of cardiovascular electrophysiology.

[13]  A. Wilde,et al.  Local depolarization abnormalities are the dominant pathophysiologic mechanism for type 1 electrocardiogram in brugada syndrome a study of electrocardiograms, vectorcardiograms, and body surface potential maps during ajmaline provocation. , 2010, Journal of the American College of Cardiology.

[14]  M. Yoshiyama,et al.  Conduction Delay in Right Ventricle as a Marker for Identifying High‐Risk Patients With Brugada Syndrome , 2009, Journal of cardiovascular electrophysiology.

[15]  A. Wilde,et al.  The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization. , 2010, Journal of molecular and cellular cardiology.

[16]  Peter Macfarlane,et al.  Diagnostic utility of bipolar precordial leads during ajmaline testing for suspected Brugada syndrome. , 2010, Heart rhythm.

[17]  M. Faouzi,et al.  New electrocardiographic criteria for discriminating between Brugada types 2 and 3 patterns and incomplete right bundle branch block. , 2011, Journal of the American College of Cardiology.

[18]  T. Arentz,et al.  Epsilon-like waves and ventricular conduction abnormalities in subjects with type 1 ECG pattern of Brugada syndrome. , 2011, Heart rhythm.

[19]  A. Baranchuk,et al.  Do patients with electrocardiographic Brugada type 1 pattern have associated right bundle branch block? A comparative vectorcardiographic study. , 2012, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[20]  J. Svendsen,et al.  Specificity of Elevated Intercostal Space ECG Recording for the Type 1 Brugada ECG Pattern , 2012, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

[21]  J. Millet,et al.  Noninvasive Localization of Maximal Frequency Sites of Atrial Fibrillation by Body Surface Potential Mapping , 2013, Circulation. Arrhythmia and electrophysiology.