New monordens produced by amidepsine-producing fungus Humicola sp. FO-2942.

Based on UV spectrum-guided purification, new monordens C, D and E, known monordens A (radicicol) and B and 5-O-methylsclerone were isolated from the fermentation broth of amidepsine-producing Humicola sp. FO-2942 by solvent extraction, silica-gel column chromatography, ODS column chromatography and HPLC. All monordens cause the cell cycle arrest at G1 and G2/M phases in Jurkat cells. But among them, monordens A and E show antifungal activity only against Aspergillus niger.

[1]  S. Ōmura,et al.  Structure elucidation of new monordens produced by Humicola sp. FO-2942. , 2003, The Journal of antibiotics.

[2]  Yoshiyuki Sakaki,et al.  Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis , 2003, Nature Biotechnology.

[3]  S. Horinouchi,et al.  Radicicol Binds and Inhibits Mammalian ATP Citrate Lyase* , 2000, The Journal of Biological Chemistry.

[4]  T. Okamoto,et al.  Sensitization of cancer cells to DNA damage-induced cell death by specific cell cycle G2 checkpoint abrogation. , 1999, Cancer research.

[5]  S. Ōmura,et al.  Zelkovamycin, a new cyclic peptide antibiotic from Streptomyces sp. K96-0670. I. Production, isolation and biological properties. , 1999, The Journal of antibiotics.

[6]  Sreenath V. Sharma,et al.  Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol , 1998, Oncogene.

[7]  S. Ōmura,et al.  Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C. , 1995, The Journal of antibiotics.

[8]  S. Ōmura,et al.  Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties. , 1995, The Journal of antibiotics.

[9]  A. Sato,et al.  Induction of differentiation of HL-60 cells by the anti-fungal antibiotic, radicicol. , 1995, The Journal of antibiotics.

[10]  H. Kwon,et al.  Radicicol, a Protein Tyrosine Kinase Inhibitor, Suppresses the Expression of Mitogen-inducible Cyclooxygenase in Macrophages Stimulated with Lipopolysaccharide and in Experimental Glomerulonephritis (*) , 1995, The Journal of Biological Chemistry.

[11]  H. Kwon,et al.  Potent and specific inhibition of p60v-src protein kinase both in vivo and in vitro by radicicol. , 1992, Cancer research.

[12]  M. Namiki,et al.  Isosclerone, a New Metabolite of Sclerotinia sclerotiorum (LIB.) DE BARY , 1968 .

[13]  C. W. Shoppee,et al.  Some metabolites of Nectria radicicola Gerlach & Nilsson (Syn. Cylindrocarpon radicicola Wr.) : The structure of radicicol (monorden) , 1966 .

[14]  C. W. Shoppee,et al.  The constitution of radicicol , 1964 .

[15]  P. Delmotte,et al.  A New Antifungal Substance of Fungal Origin , 1953, Nature.