The Drosophila Giant Fiber System

Normal functioning of the nervous system depends on the formation of vast numbers of specific connections between neurons. During development, each of the thousands, millions, or billions of cells in a nervous system connects with a specific set of target cells. We currently have no knowledge of the molecular basis of this specificity. The long-term goal of our work is to identify genes that are directly involved in neural connectivity and then to use this knowledge to identify the gene products necessary for proper connectivity. It will be a major advance in neuroscience if the class (or classes) of molecules involved in nerve-cell recognition and connection can be identified.

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