AN ANALYSIS OF GRANULOCYTE KINETICS IN BLOOD AND BONE MARROW *

Technics for labeling granulocytes in human blood and bone marrow with tritiated thymidine ( H3-Th) , P32-labeled sodium phosphate (radiophosphate) and diisopropylfluorophosphate ( DFP32) have now been developed to the point where further analysis of the experimental results in terms of a model of granulocyte dynamics seems justified. The purpose of this report is to present a mathematical model of granulocyte kinetics which will describe the time course of radioactivity in blood granulocytes obtained in human subjects following the administration of these labels.

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