Healthcare paradigms, due to demographic changes, are definitely aiming at effective prevention and early diagnosis strategies. This inherently calls for continuous monitoring of (ageing) people in their own living environment and while attending at daily living activities. Such monitoring may rely on a wide range of sensing technologies, each featuring different trade-offs among main parameters such as accuracy, expressivity, cost, reliability and intrusively. This includes clinical sensors (suitable for self-managed, precise measurement of physiological parameters), wearable devices (continuously monitoring health or activity features) and environmental sensors distributed in the living environment (suitable for indirect assessment of relevant behaviours, besides serving basic safety purposes). In this chapter, the meaning of human monitoring from a home-care point of view will be defined, and the basic sensor categories will be reviewed. Then, the design and the main features of the CARDEA home monitoring system will be discussed. Finally, some application examples, coming from European project living-lab experiences, will be illustrated, and some results obtained by data fusion and analysis techniques, suitable for inferring health and wellness information by effectively correlating raw data coming from the sensor field, will be presented.