Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss

[1]  L. Dobrunz,et al.  Klotho regulates CA1 hippocampal synaptic plasticity , 2017, Neuroscience.

[2]  D. Haffner,et al.  Klotho and fibroblast growth factor 23 in cerebrospinal fluid in children , 2017, Journal of Bone and Mineral Metabolism.

[3]  S. Bandinelli,et al.  Plasma Klotho and Cognitive Decline in Older Adults: Findings From the InCHIANTI Study. , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

[4]  M. Cañete,et al.  Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression , 2015, PloS one.

[5]  A. Symes,et al.  Runx1 promotes proliferation and neuronal differentiation in adult mouse neurosphere cultures. , 2015, Stem cell research.

[6]  Philip P. Foster,et al.  Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways , 2015, PloS one.

[7]  C. Abraham,et al.  The Anti-Aging Protein Klotho Enhances Remyelination Following Cuprizone-Induced Demyelination , 2015, Journal of Molecular Neuroscience.

[8]  K. Fabel,et al.  Development of the adult neurogenic niche in the hippocampus of mice , 2015, Front. Neuroanat..

[9]  L. Mucke,et al.  Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice , 2015, The Journal of Neuroscience.

[10]  D. Bennett,et al.  Variation in longevity gene KLOTHO is associated with greater cortical volumes , 2015, Annals of clinical and translational neurology.

[11]  M. Accavitti-Loper,et al.  Development and characterization of monoclonal antibodies to detect klotho. , 2014, Monoclonal antibodies in immunodiagnosis and immunotherapy.

[12]  Yan Li,et al.  Regulation and function of adult neurogenesis: from genes to cognition. , 2014, Physiological reviews.

[13]  D. Harris,et al.  The Neuroprotective Effect of Klotho is Mediated via Regulation of Members of the Redox System* , 2014, The Journal of Biological Chemistry.

[14]  U. Bonuccelli,et al.  Cognitive impairment and cardiovascular disease: so near, so far. , 2014, International journal of cardiology.

[15]  S. Pleasure,et al.  The development of hippocampal cellular assemblies , 2014, Wiley interdisciplinary reviews. Developmental biology.

[16]  R. Palmiter,et al.  Genetic Activation of ERK5 MAP Kinase Enhances Adult Neurogenesis and Extends Hippocampus-Dependent Long-Term Memory , 2014, The Journal of Neuroscience.

[17]  A. Kribben,et al.  Cognitive impairment in chronic kidney disease: clinical findings, risk factors and consequences for patient care , 2014, Journal of Neural Transmission.

[18]  L. Ferrucci,et al.  Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease , 2014, Neuroscience Letters.

[19]  O. Paulsen,et al.  GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity , 2014, Philosophical Transactions of the Royal Society B: Biological Sciences.

[20]  Richard L. Dees,et al.  The role of the dorsal dentate gyrus in object and object-context recognition , 2013, Neurobiology of Learning and Memory.

[21]  A. Cebrian-Silla,et al.  Adult Neural Stem Cells From the Subventricular Zone: A Review of the Neurosphere Assay , 2013, Anatomical record.

[22]  S. Clinton,et al.  Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood , 2013, Brain Research.

[23]  K. Luan Phan,et al.  The contextual brain: implications for fear conditioning, extinction and psychopathology , 2013, Nature Reviews Neuroscience.

[24]  Youhua Liu,et al.  Loss of Klotho contributes to kidney injury by derepression of Wnt/β-catenin signaling. , 2013, Journal of the American Society of Nephrology : JASN.

[25]  Peng Ye,et al.  Wnt7a Regulates Multiple Steps of Neurogenesis , 2013, Molecular and Cellular Biology.

[26]  Jacques I Wadiche,et al.  GABA Depolarization Is Required for Experience-Dependent Synapse Unsilencing in Adult-Born Neurons , 2013, The Journal of Neuroscience.

[27]  J. Luebke,et al.  The Antiaging Protein Klotho Enhances Oligodendrocyte Maturation and Myelination of the CNS , 2013, The Journal of Neuroscience.

[28]  D. Rosene,et al.  Promoter methylation and age-related downregulation of Klotho in rhesus monkey , 2012, AGE.

[29]  T. Abel,et al.  Aging impairs hippocampus-dependent long-term memory for object location in mice , 2012, Neurobiology of Aging.

[30]  A. F. Schinder,et al.  Requirement of adult-born neurons for hippocampus-dependent learning , 2012, Behavioural Brain Research.

[31]  R. Rostomily,et al.  Increased Re‐Entry into Cell Cycle Mitigates Age‐Related Neurogenic Decline in the Murine Subventricular Zone , 2011, Stem cells.

[32]  P. Lowenstein,et al.  Combined Flt3L/TK Gene Therapy Induces Immunological Surveillance Which Mediates an Immune Response Against a Surrogate Brain Tumor Neoantigen. , 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

[33]  M. Asashima,et al.  Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[34]  Erika Pastrana,et al.  Eyes wide open: a critical review of sphere-formation as an assay for stem cells. , 2011, Cell stem cell.

[35]  C. Morshead,et al.  Wnt Signaling Regulates Symmetry of Division of Neural Stem Cells in the Adult Brain and in Response to Injury , 2011, Stem cells.

[36]  Jacques I Wadiche,et al.  Enhanced Integration of Newborn Neurons after Neonatal Insults , 2011, Front. Neurosci..

[37]  M. Wood,et al.  HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner. , 2011, Learning & memory.

[38]  O. Togao,et al.  Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice* , 2011, The Journal of Biological Chemistry.

[39]  S. Kernie,et al.  Developmental profiling of postnatal dentate gyrus progenitors provides evidence for dynamic cell‐autonomous regulation , 2011, Hippocampus.

[40]  S. Trouche,et al.  Young hippocampal neurons are critical for recent and remote spatial memory in adult mice , 2010, Neuroscience.

[41]  M. Econs,et al.  Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects. , 2010, Biochemical and biophysical research communications.

[42]  Yvette I. Sheline,et al.  Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system , 2010, Brain Research.

[43]  Alexei L. Vyssotski,et al.  Early age-related changes in adult hippocampal neurogenesis in C57 mice , 2010, Neurobiology of Aging.

[44]  K. Nave,et al.  Neurod1 is essential for the survival and maturation of adult-born neurons , 2009, Nature Neuroscience.

[45]  C. Bramham,et al.  Object-Place Recognition Learning Triggers Rapid Induction of Plasticity-Related Immediate Early Genes and Synaptic Proteins in the Rat Dentate Gyrus , 2009, Neural plasticity.

[46]  Jun-Hyeok Choi,et al.  Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory , 2009, Molecular Brain.

[47]  Y. Ouchi,et al.  Airspace enlargement with airway cell apoptosis in klotho mice: a model of aging lung. , 2008, The journals of gerontology. Series A, Biological sciences and medical sciences.

[48]  K. Malizos,et al.  Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population , 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[49]  A. Bacci,et al.  The Timing of Differentiation of Adult Hippocampal Neurons Is Crucial for Spatial Memory , 2008, PLoS biology.

[50]  K. Rosenblatt,et al.  Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1 , 2008, Proceedings of the National Academy of Sciences.

[51]  T. Gotow,et al.  Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice , 2008, Neuroscience.

[52]  P. Lowenstein,et al.  Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits. , 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

[53]  C. Kuo,et al.  Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging , 2007, Science.

[54]  S. Ge,et al.  A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain , 2007, Neuron.

[55]  H. Cameron,et al.  Decreased neurogenesis in aged rats results from loss of granule cell precursors without lengthening of the cell cycle , 2007, The Journal of comparative neurology.

[56]  S. Fischer,et al.  Gender and endogenous levels of estradiol do not influence adult hippocampal neurogenesis in mice , 2007, Hippocampus.

[57]  B. McEwen,et al.  N-methyl-d-aspartate receptor expression during adult neurogenesis in the rat dentate gyrus , 2007, Neuroscience.

[58]  A. Shetty,et al.  The window and mechanisms of major age‐related decline in the production of new neurons within the dentate gyrus of the hippocampus , 2006, Aging cell.

[59]  Tobias Plümpe,et al.  Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation , 2006, BMC Neuroscience.

[60]  E. Kandel,et al.  Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus , 2006, Proceedings of the National Academy of Sciences.

[61]  K. Rosenblatt,et al.  Regulation of Fibroblast Growth Factor-23 Signaling by Klotho* , 2006, Journal of Biological Chemistry.

[62]  Animesh Nandi,et al.  Suppression of Aging in Mice by the Hormone Klotho , 2005, Science.

[63]  I. Sato,et al.  NADH dehydrogenase activity and expression of mRNA of complex I (ND1, 51kDa, and 75kDa) in heart mitochondria of klotho mouse. , 2005, Okajimas folia anatomica Japonica.

[64]  Brent A Reynolds,et al.  Neural stem cells and neurospheres—re-evaluating the relationship , 2005, Nature Methods.

[65]  I. Deary,et al.  KLOTHO genotype and cognitive ability in childhood and old age in the same individuals , 2005, Neuroscience Letters.

[66]  D. Arking,et al.  Association Between a Functional Variant of the KLOTHO Gene and High-Density Lipoprotein Cholesterol, Blood Pressure, Stroke, and Longevity , 2005, Circulation research.

[67]  S. Pleasure,et al.  Morphogenesis of the Dentate Gyrus: What We Are Learning from Mouse Mutants , 2005, Developmental Neuroscience.

[68]  A. Shetty,et al.  Newly born cells in the ageing dentate gyrus display normal migration, survival and neuronal fate choice but endure retarded early maturation , 2005, The European journal of neuroscience.

[69]  H. Yamada,et al.  Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. , 2004, Cell structure and function.

[70]  K. Nozaki,et al.  Secreted Klotho protein in sera and CSF: implication for post‐translational cleavage in release of Klotho protein from cell membrane , 2004, FEBS letters.

[71]  K. Kamiya,et al.  Sinoatrial Node Dysfunction and Early Unexpected Death of Mice With a Defect of klotho Gene Expression , 2004, Circulation.

[72]  M. Low,et al.  A Transgenic Marker for Newly Born Granule Cells in Dentate Gyrus , 2004, The Journal of Neuroscience.

[73]  D. Steindler,et al.  Neural stem and progenitor cells in nestin‐GFP transgenic mice , 2004, The Journal of comparative neurology.

[74]  A. Shetty,et al.  Efficacy of doublecortin as a marker to analyse the absolute number anddendritic growth of newly generated neurons in the adult dentate gyrus , 2004, The European journal of neuroscience.

[75]  K. Fukuda,et al.  Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. , 2003, Molecular endocrinology.

[76]  Jürgen Winkler,et al.  Transient expression of doublecortin during adult neurogenesis , 2003, The Journal of comparative neurology.

[77]  T. Nabeshima,et al.  Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[78]  T. Spector,et al.  Klotho Gene Polymorphisms Associated With Bone Density of Aged Postmenopausal Women , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[79]  Y. Nabeshima,et al.  Mediation of Unusually High Concentrations of 1,25-Dihydroxyvitamin D in Homozygous klotho Mutant Mice by Increased Expression of Renal 1α-Hydroxylase Gene. , 2002, Endocrinology.

[80]  I. Mian,et al.  Association of human aging with a functional variant of klotho , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[81]  Y. Ben-Ari Developing networks play a similar melody , 2001, Trends in Neurosciences.

[82]  E. Shimizu,et al.  Genetic enhancement of learning and memory in mice , 1999, Nature.

[83]  M. Kuro-o,et al.  Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein 1 , 1998, FEBS letters.

[84]  Tadashi Kaname,et al.  Mutation of the mouse klotho gene leads to a syndrome resembling ageing , 1997, Nature.

[85]  F. Gage,et al.  Genetic influence on neurogenesis in the dentate gyrus of adult mice. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[86]  H. Gundersen,et al.  Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator , 1991, The Anatomical record.

[87]  L. Mucke,et al.  Life Extension Factor Klotho Enhances Cognition , 2016 .

[88]  Hu Li,et al.  The Anti-Aging and Tumor Suppressor Protein Klotho Enhances Differentiation of a Human Oligodendrocytic Hybrid Cell Line , 2014, Journal of Molecular Neuroscience.

[89]  D. Rosene,et al.  Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey , 2008, Glia.

[90]  B. McEwen,et al.  The role of N‐methyl‐D‐asparate receptors in neurogenesis , 2006, Hippocampus.

[91]  Y. Nabeshima,et al.  Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene. , 2002, Endocrinology.

[92]  R. Nagai,et al.  Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life. , 2000, American journal of respiratory cell and molecular biology.