Intrathecal neostigmine with bupivacaine for infants undergoing lower abdominal and urogenital procedures: dose response

Background: Intrathecal (IT) neostigmine produces dose‐dependent analgesia in adults. However, the dose of spinal neostigmine has not been investigated in infants. The purpose of this study was to assess spinal anesthesia (SA) duration provided by four doses of spinal neostigmine added to bupivacaine for lower abdominal and urogenital procedures in infants.

[1]  Y. Batra,et al.  Dose–response study of intrathecal fentanyl added to bupivacaine in infants undergoing lower abdominal and urologic surgery , 2008, Paediatric anaesthesia.

[2]  K. Ho,et al.  Use of Intrathecal Neostigmine as an Adjunct to Other Spinal Medications in Perioperative and Peripartum Analgesia: A Meta-analysis , 2005, Anaesthesia and intensive care.

[3]  R. Verdier,et al.  Clonidine Prolongs Spinal Anesthesia in Newborns: A Prospective Dose-Ranging Study , 2004, Anesthesia and analgesia.

[4]  G. Lederhaas.  Spinal anaesthesia in paediatrics. , 2003, Best practice & research. Clinical anaesthesiology.

[5]  P. Tan,et al.  Efficacy of intrathecal neostigmine for the relief of postinguinal herniorrhaphy pain , 2000, Acta anaesthesiologica Scandinavica.

[6]  M. Owen,et al.  Low-dose clonidine and neostigmine prolong the duration of intrathecal bupivacaine-fentanyl for labor analgesia. , 2000, Anesthesiology.

[7]  S. Liu,et al.  Dose-response effects of spinal neostigmine added to bupivacaine spinal anesthesia in volunteers. , 1999, Anesthesiology.

[8]  J. Eisenach.  Muscarinic-mediated analgesia. , 1999, Life sciences.

[9]  J. Eisenach,et al.  A Multi‐center Study of Intrathecal Neostigmine for Analgesia following Vaginal Hysterectomy , 1998, Anesthesiology.

[10]  G. Lauretti,et al.  Intrathecal neostigmine for postoperative analgesia after orthopedic surgery. , 1997, Journal of clinical anesthesia.

[11]  M. Mok,et al.  Enhancement of Analgesic Effect of Intrathecal Neostigmine and Clonidine on Bupivacaine Spinal Anesthesia , 1997, Regional Anesthesia & Pain Medicine.

[12]  J. Eisenach,et al.  Intrathecal neostigmine for post-cesarean section analgesia: dose response. , 1997, Anesthesia and analgesia.

[13]  J. Eisenach,et al.  Spinal Neostigmine Diminishes, but Does Not Abolish, Hypotension from Spinal Bupivacaine in Sheep , 1996, Anesthesia and analgesia.

[14]  G. Lauretti,et al.  Dose-Response Study of Intrathecal Morphine Versus Intrathecal Neostigmine, Their Combination, or Placebo for Postoperative Analgesia in Patients Undergoing Anterior and Posterior Vaginoplasty , 1996, Anesthesia and analgesia.

[15]  J. Eisenach,et al.  Cerebrospinal Fluid Norepinephrine and Acetylcholine Concentrations During Acute Pain , 1996, Anesthesia and analgesia.

[16]  M. Grafe,et al.  Studies on the Safety of Chronically Administered Intrathecal Neostigmine Methylsulfate in Rats and Dogs , 1995, Anesthesiology.

[17]  J. Eisenach,et al.  Phase I Safety Assessment of Intrathecal Neostigmine Methylsulfate in Humans , 1995, Anesthesiology.

[18]  T. Gan,et al.  Use of Neostigmine in the Management of Acute Postoperative Pain and Labour Pain , 2006, CNS drugs.

[19]  A. C. Primavesi.  ▪ Low-Dose Clonidine and Neostigmine Prolong the Duration of Intrathecal Bupivacaine-Fentanyl for Labor Analgesia: , 2000 .

[20]  T. Voepel-Lewis,et al.  The FLACC: a behavioral scale for scoring postoperative pain in young children. , 1997, Pediatric nursing.