Effects of hypertension on the early central nervous system function in patients after surgery for aortic dissection

Objective To investigate the effects of hypertension on the early central nervous system function in patients after surgery for aortic dissection.Methods Seventy-seven patients after surgery for aortic dissection were enrolled from Nanjing Drum Tower Hospital between November 2008 and May 2011.They were divided into injury group(n=35) and control group(n=42) according to whether or not the central nervous system injury.Univariate and multivariate Logistic regression analysis was employed to analyze its factors.Results Compared with control group,the injury group had higher hypertension prevalence\[80%(28/35)vs 45%(19/42),P0.05\] and more blood loss during operation\[(5037.1±3888.1)vs(2466.7±2194.2)mL,P0.01\].Postoperative 24-hour urinary output and the values of PH and PaO2 based on the first blood gas analysis during postoperative ICU(intensive care unit) stay were lower in injury group than those in control group\[urinary output:(1092.9±727.2) vs(1399.3±510.5) mL;PH:(7.39±0.10)vs(7.44±0.08);PaO2:(81.8±30.7) vs(116.1±56.9)mm Hg,all P0.05\].The history of hypertension,blood loss during operation,postoperative 24-hour urinary output,and the values of PH and PaO2 based on the first blood gas analysis during postoperative ICU stay obviously affected the recovery of central nervous system function by univariate analysis.The history of hypertension(OR value 0.196) and the first PaO2(OR value 1.015) of blood gas analysis during postoperative ICU stay were independent risk factors for early CNS disorder(P0.05) by multivariate analysis.Conclusions Hypertension is independent risk factors for early central nervous system function recovery in patients after surgery for aortic dissection.