Effect of 5-fluorocytosine and amphotericin B on Candida albicans infection in mice.

The effects of administration of 5-fluorocytosine alone or in combination with amphotericin B on the course of fatal Candida albicans infection in mice were studied. The survival rate was 13.7% for mice treated with 5-fluorocytosine and 15.9% for mice treated with amphotericin B. When both agents were given, the rate of survival increased to 79.5%. Counts of C. albicans in the kidneys of infected mice treated with 5-fluorocytosine and amphotericin B were 100- and 10fold less when compared with numbers in the kidneys of mice treated with either agent alone or not treated at all, respectively.

[1]  A. R. English,et al.  Pirbenicillin: Pharmacokinetic Parameters in Mice , 1976, Antimicrobial Agents and Chemotherapy.

[2]  E. Grunberg,et al.  Chemotherapeutic Activity of 5-Fluorocytosine and Amphotericin B Against Candida albicans in Mice , 1973, Antimicrobial Agents and Chemotherapy.

[3]  E. Block,et al.  The Combined Effect of 5-Fluorocytosine and Amphotericin B in the Therapy of Murine Cryptococcosis , 1973, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[4]  J. Klastersky,et al.  Clinical Significance of In Vitro Synergism Between Antibiotics in Gram-Negative Infections , 1972, Antimicrobial Agents and Chemotherapy.

[5]  G. Medoff,et al.  Synergistic Action of Amphotericin B and 5-Fluorocytosine Against Yeast-Like Organisms 1 , 1971, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[6]  R. Perkins,et al.  5-fluorocytosine in the treatment of cryptococcal and candida mycoses. , 1971, Annals of internal medicine.

[7]  S. Shadomy.  Further In Vitro Studies with 5-Fluorocytosine , 1970, Infection and immunity.

[8]  J. A. Mccay,et al.  In vitro susceptibility of Cryptococcus neoformans to amphotericin B, hamycin, and 5-fluorocytosine. , 1968, Antimicrobial agents and chemotherapy.

[9]  L. Friedman,et al.  PATHOGENICITY OF CANDIDA , 1961, Journal of bacteriology.