Smooth Goodness-of-Fit Tests for the Baseline Hazard in Cox's Proportional Hazards Model

Abstract For the Cox proportional hazards model, the goodness-of-fit problem of testing whether the baseline hazard rate function λ(·) equals some specified hazard rate function λ0(·) in the presence of incomplete data is considered. Extending Neyman's idea, the goodness-of-fit tests are score tests obtained by embedding λ(·) in a larger family of hazard rate functions developed through smooth and possibly random transformations of λ0(·). But whereas their smooth alternatives were formulated through the density function, my formulation is through the hazard rate function, which is more natural in failure time models where model specification is now done through hazard rates. Furthermore, my smooth alternatives are allowed to be data driven or dynamic. Through this machinery, classes of omnibus, as well as directional goodness-of-fit tests are obtained. Moreover, this machinery provides a theoretically sound method for combining varied directional goodness-of-fit tests into omnibus tests. Some of the resul...

[1]  D. Cox Regression Models and Life-Tables , 1972 .

[2]  Constantine Gatsonis,et al.  Simple nonparametric tests for a known standard survival based on censored data , 1985 .

[3]  Klaus J. Utikal,et al.  Goodness-of-fit Tests for Additive Hazards and Proportional Hazards Models , 1991 .

[4]  Jon E. Hyde,et al.  Testing survival under right censoring and left truncation , 1977 .

[5]  Andrew Chesher,et al.  Residual analysis for censored duration data , 1985 .

[6]  C H Chen,et al.  Diagnostic plots in Cox's regression model. , 1991, Biometrics.

[7]  Olivier Thas,et al.  Smooth tests of goodness of fit , 1989 .

[8]  Niels Keiding,et al.  Statistical Models Based on Counting Processes , 1993 .

[9]  J. Kalbfleisch,et al.  The Statistical Analysis of Failure Time Data , 1980 .

[10]  R. Kay,et al.  Proportional Hazard Regression Models and the Analysis of Censored Survival Data , 1977 .

[11]  R. Randles On Tests Applied to Residuals , 1984 .

[12]  Joel L. Horowitz,et al.  A Generalized Moments Specification Test of the Proportional Hazards Model , 1992 .

[13]  O. Aalen Nonparametric Inference for a Family of Counting Processes , 1978 .

[14]  N. Hjort Goodness of fit tests in models for life history data based on cumulative hazard rates , 1990 .

[15]  Elja Arjas,et al.  A Graphical Method for Assessing Goodness of Fit in Cox's Proportional Hazards Model , 1988 .

[16]  David A. Schoenfeld,et al.  Chi-squared goodness-of-fit tests for the proportional hazards regression model , 1980 .

[17]  D. Collett Modelling survival data , 1994 .

[18]  Girish Patwardhan,et al.  Tests for exponentiality , 1988 .

[19]  P. Grambsch,et al.  Martingale-based residuals for survival models , 1990 .

[20]  M. Akritas Pearson-Type Goodness-of-Fit Tests: The Univariate Case , 1988 .

[21]  Edsel A. Peña,et al.  Properties of test statistics applied to residuals in failure time models , 1999 .

[22]  On residual plots for relative risk regression , 1991 .

[23]  Donald A. Pierce,et al.  Goodness-of-Fit Tests for Censored Survival Data , 1985 .

[24]  J. Crowley,et al.  Covariance Analysis of Heart Transplant Survival Data , 1977 .

[25]  J. Kalbfleisch Statistical Inference Under Order Restrictions , 1975 .

[26]  J. Jacod Multivariate point processes: predictable projection, Radon-Nikodym derivatives, representation of martingales , 1975 .

[27]  James A. Koziol,et al.  A Cramér-von Mises statistic for randomly censored data , 1976 .

[28]  Per Kragh Andersen,et al.  Testing Goodness of Fit of Cox's Regression and Life Model , 1982 .

[29]  R. Gill,et al.  Cox's regression model for counting processes: a large sample study : (preprint) , 1982 .

[30]  Donald A. Pierce,et al.  Neyman's Smooth Goodness-of-Fit Test When the Hypothesis Is Composite , 1979 .

[31]  David R. Cox,et al.  Regression models and life tables (with discussion , 1972 .

[32]  J. Neyman »Smooth test» for goodness of fit , 1937 .

[33]  W. J. Hall,et al.  Asymptotically uniformly most powerful tests in parametric and semiparametric models , 1996 .

[34]  D. Cox,et al.  A General Definition of Residuals , 1968 .

[35]  R. Loynes The Empirical Distribution Function of Residuals from Generalised Regression , 1980 .

[36]  David Collett Modelling Survival Data in Medical Research , 1994 .

[37]  M. Hollander,et al.  Testing to Determine the Underlying Distribution Using Randomly Censored Data. , 1979 .

[38]  Niels Keiding,et al.  [Linear Nonparametric Tests for Comparison of Counting Processes, with Applications to Censored Survival Data]: Reply to Discussion , 1982 .

[39]  L. J. Wei,et al.  Testing Goodness of Fit for Proportional Hazards Model with Censored Observations , 1984 .

[40]  Tony Lancaster,et al.  Generalised Residuals and Heterogeneous Duration Models: The Exponential Case , 1983 .

[41]  J. Crowley,et al.  A Diagnostic for Cox Regression and General Conditional Likelihoods , 1985 .

[42]  Gang Li,et al.  Generalized Pearson-Fisher Chi-Square Goodness-of-Fit Tests, with Applications to Models with Life History Data , 1993 .

[43]  J. Durbin Distribution theory for tests based on the sample distribution function , 1973 .

[44]  D. Cox,et al.  Analysis of Survival Data. , 1985 .

[45]  Edsel A. Peña,et al.  Smooth goodness-of-fit tests for composite hypothesis in hazard based models , 1998 .

[46]  E. Peña,et al.  Ancillarity properties of generalized residuals with applications in failure time models , 1998 .

[47]  Stephen W. Lagakos,et al.  The graphical evaluation of explanatory variables in proportional hazard regression models , 1981 .

[48]  Danyu Lin,et al.  Model checking techniques for parametric regression with censored data , 1996 .

[49]  Zhiliang Ying,et al.  Prediction of survival probability based on a linear regression model , 1992 .

[50]  Odd O. Aalen,et al.  Random time changes for multivariate counting processes , 1978 .

[51]  E. Peña,et al.  Properties of hazard-based residuals and implications in model diagnostics , 1995 .

[52]  Niels Keiding,et al.  Linear Nonparametric Tests for Comparison of Counting Processes, with Applications to Censored Survival Data, Correspondent Paper , 1982 .

[53]  Ronald H. Randles,et al.  On the Asymptotic Normality of Statistics with Estimated Parameters , 1982 .

[54]  W. Barlow,et al.  Residuals for relative risk regression , 1988 .

[55]  D. Pierce The Asymptotic Effect of Substituting Estimators for Parameters in Certain Types of Statistics , 1982 .