Acute irritant contact dermatitis from Agave americana L.

induction, approximately 25% showed slight or definite erythema. During the challenge phase, of the 200 subjects, only 7 at the 48-h evaluation, and 12 at the 72-h evaluation, showed slight erythema. 1 subject at the 72-h reading had definite erythema. More severe responses, which would have been expected if delayed contact sensitization had occurred, were not observed. No rechallenge was considered necessary. It was concluded that there was no evidence for sensitization to EGBE under the conditions of this study. Based on this study, and a review of the other relevant toxicity information, The Expert Panel of the Cosmetic Ingredient Review, a special panel of the CTFA, determined that EGBE was "safe in hair and nail products at concentrations up to 10%" (3). SHORT COMMUNICATIONS

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