ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through β1 integrin-dependent activation of PI3-kinase

[1]  J. Gills,et al.  Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy. , 2005, Cancer research.

[2]  P. Rabinovitch,et al.  The cell cycle phases of DNA damage and repair initiated by topoisomerase II-targeting chemotherapeutic drugs. , 2005, Mutation research.

[3]  J. Ferlay,et al.  Global Cancer Statistics, 2002 , 2005, CA: a cancer journal for clinicians.

[4]  P. Vogt,et al.  Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Klaus Resch,et al.  Phosphorylation of Serine 468 by GSK-3β Negatively Regulates Basal p65 NF-κB Activity* , 2004, Journal of Biological Chemistry.

[6]  Jiri Bartek,et al.  Cell-cycle checkpoints and cancer , 2004, Nature.

[7]  J. Massagué,et al.  G1 cell-cycle control and cancer , 2004, Nature.

[8]  R. Nho,et al.  Focal Adhesion Kinase Is Upstream of Phosphatidylinositol 3-Kinase/Akt in Regulating Fibroblast Survival in Response to Contraction of Type I Collagen Matrices via a β1 Integrin Viability Signaling Pathway* , 2004, Journal of Biological Chemistry.

[9]  J. Downward PI 3-kinase, Akt and cell survival. , 2004, Seminars in cell & developmental biology.

[10]  G. Borisy,et al.  Cell Migration: Integrating Signals from Front to Back , 2003, Science.

[11]  M Zweyer,et al.  The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27Kip1 and control of cyclin D1 expression , 2003, Leukemia.

[12]  J. Boonstra Progression through the G1‐phase of the on‐going cell cycle , 2003, Journal of cellular biochemistry.

[13]  Richard A. Woo,et al.  Cyclin-Dependent Kinases and S Phase Control in Mammalian Cells , 2003, Cell cycle.

[14]  J. Carroll,et al.  Constitutive overexpression of cyclin D1 but not cyclin E confers acute resistance to antiestrogens in T-47D breast cancer cells. , 2002, Cancer research.

[15]  J. Litz,et al.  Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy. , 2002, Molecular cancer therapeutics.

[16]  J. Su,et al.  Expression of focal adhesion kinase and α5 and β1 integrins in carcinomas and its clinical significance , 2002 .

[17]  T. Sethi,et al.  Integrins and extracellular matrix: a novel mechanism of multidrug resistance , 2002, Expert review of anticancer therapy.

[18]  Kenneth M. Yamada,et al.  Fibronectin, integrins, and growth control , 2001, Journal of cellular physiology.

[19]  W. Dalton,et al.  Reduction in drug-induced DNA double-strand breaks associated with beta1 integrin-mediated adhesion correlates with drug resistance in U937 cells. , 2001, Blood.

[20]  F. Aoudjit,et al.  Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells , 2001, Oncogene.

[21]  J. Pollard,et al.  Genetic Evidence for the Interactions of Cyclin D1 and p27Kip1 in Mice , 2001, Molecular and Cellular Biology.

[22]  W. Dalton,et al.  Adhesion to fibronectin via β1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR) , 2000, Oncogene.

[23]  J. Baldassare,et al.  Phosphatidylinositol 3-Kinase Activity Regulates α-Thrombin-stimulated G1 Progression by Its Effect on Cyclin D1 Expression and Cyclin-dependent Kinase 4 Activity* , 2000, The Journal of Biological Chemistry.

[24]  S. Dedhar,et al.  Cell-Extracellular Matrix Interactions Stimulate the AP-1 Transcription Factor in an Integrin-Linked Kinase- and Glycogen Synthase Kinase 3-Dependent Manner , 1999, Molecular and Cellular Biology.

[25]  Christopher Haslett,et al.  Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo , 1999, Nature Medicine.

[26]  J. Uhm,et al.  Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[27]  R. Rintoul,et al.  The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway. , 1998, Cancer research.

[28]  M. Roussel,et al.  Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. , 1998, Genes & development.

[29]  D. Resnitzky Ectopic expression of cyclin D1 but not cyclin E induces anchorage-independent cell cycle progression , 1997, Molecular and cellular biology.

[30]  Asim Khwaja,et al.  Matrix adhesion and Ras transformation both activate a phosphoinositide 3‐OH kinase and protein kinase B/Akt cellular survival pathway , 1997, The EMBO journal.

[31]  Y. Hannun,et al.  Apoptosis and the dilemma of cancer chemotherapy. , 1997, Blood.

[32]  James M. Roberts,et al.  Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein , 1996, The Journal of cell biology.

[33]  T. Hunter,et al.  Dependence of Cyclin E-CDK2 Kinase Activity on Cell Anchorage , 1996, Science.

[34]  John Calvin Reed,et al.  Anchorage dependence, integrins, and apoptosis , 1994, Cell.

[35]  James M. Roberts,et al.  A link between cyclin A expression and adhesion-dependent cell cycle progression. , 1993, Science.

[36]  S. Kaufmann Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. , 1989, Cancer research.

[37]  P. Olive Detection of DNA damage in individual cells by analysis of histone H2AX phosphorylation. , 2004, Methods in cell biology.

[38]  Z. Halpern,et al.  Stromal extracellular matrix reduces chemotherapy-induced apoptosis in colon cancer cell lines , 2004, Clinical & Experimental Metastasis.

[39]  Klaus Resch,et al.  Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity. , 2004, The Journal of biological chemistry.

[40]  M. Tonato,et al.  Relevance of p53, bcl-2 and Rb expression on resistance to cisplatin-based chemotherapy in advanced non-small cell lung cancer. , 2003, Lung cancer.

[41]  J. Su,et al.  Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance. , 2002, World journal of gastroenterology.

[42]  S. Chin,et al.  Cell cycle checkpoint evasion and protracted cell cycle arrest in X-irradiated small-cell lung carcinoma cells. , 1999, International journal of radiation biology.