Imaging brain damage in first‐degree relatives of sporadic and familial multiple sclerosis

Our objective was to assess brain damage in first‐degree relatives of patients with sporadic and familial multiple sclerosis (MS).

[1]  B. Trapp,et al.  Neuropathobiology of multiple sclerosis. , 2005, Neurologic clinics.

[2]  Mark W. Woolrich,et al.  Advances in functional and structural MR image analysis and implementation as FSL , 2004, NeuroImage.

[3]  C. Poser Multiple sclerosis trait: the premorbid stage of multiple sclerosis. A hypothesis , 2004, Acta neurologica Scandinavica.

[4]  A. J. Thompson,et al.  Magnetic resonance studies of abnormalities in the normal appearing white matter and grey matter in multiple sclerosis , 2003, Journal of Neurology.

[5]  H. Lassmann,et al.  Neuropathology of multiple sclerosis—new concepts , 2003, Brain Research Bulletin.

[6]  Massimo Filippi,et al.  The use of quantitative magnetic-resonance-based techniques to monitor the evolution of multiple sclerosis , 2003, The Lancet Neurology.

[7]  P. M. Matthews,et al.  Evidence of early cortical atrophy in MS , 2003, Neurology.

[8]  Nick C Fox,et al.  Computer-assisted imaging to assess brain structure in healthy and diseased brains , 2003, The Lancet Neurology.

[9]  Stephen M. Smith,et al.  Accurate, Robust, and Automated Longitudinal and Cross-Sectional Brain Change Analysis , 2002, NeuroImage.

[10]  David H. Miller,et al.  Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance. , 2002, Brain : a journal of neurology.

[11]  E. Wakeland,et al.  Susceptibility genes in the pathogenesis of murine lupus , 2002, Arthritis research.

[12]  P. Contu,et al.  Patients with multiple sclerosis and risk of type 1 diabetes mellitus in Sardinia, Italy: a cohort study , 2002, The Lancet.

[13]  Massimo Filippi,et al.  MTR discloses subtle changes in the normal-appearing tissue from relatives of patients with MS , 2002, Neurology.

[14]  P. Contu,et al.  Genetic factors and the founder effect explain familial MS in Sardinia , 2002, Neurology.

[15]  J. Todd,et al.  The inter-regional distribution of HLA class II haplotypes indicates the suitability of the Sardinian population for case-control association studies in complex diseases. , 2000, Human molecular genetics.

[16]  E. Granieri,et al.  The increasing incidence and prevalence of MS in a Sardinian province , 2000, Neurology.

[17]  G. B. Pike,et al.  Multiple sclerosis: magnetization transfer MR imaging of white matter before lesion appearance on T2-weighted images. , 2000, Radiology.

[18]  D. Clayton,et al.  Autoimmune disease in first-degree relatives of patients with multiple sclerosis. A UK survey. , 2000, Brain : a journal of neurology.

[19]  F. Barkhof,et al.  Axonal loss in multiple sclerosis lesions: Magnetic resonance imaging insights into substrates of disability , 1999, Annals of neurology.

[20]  M Filippi,et al.  Normal-appearing white matter changes in multiple sclerosis: the contribution of magnetic resonance techniques , 1999, Multiple sclerosis.

[21]  J. Udupa,et al.  Familial multiple sclerosis: volumetric assessment in clinically symptomatic and asymptomatic individuals , 1999, Multiple sclerosis.

[22]  G. Comi,et al.  Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. , 1997, Brain : a journal of neurology.

[23]  M. Filippi,et al.  A magnetization transfer study of white matter in siblings of multiple sclerosis patients , 1997, Journal of the Neurological Sciences.

[24]  R I Grossman,et al.  Magnetization transfer: theory and clinical applications in neuroradiology. , 1994, Radiographics : a review publication of the Radiological Society of North America, Inc.

[25]  R I Grossman,et al.  Experimental allergic encephalomyelitis and multiple sclerosis: lesion characterization with magnetization transfer imaging. , 1992, Radiology.

[26]  H Lechner,et al.  Criteria for an increased specificity of MRI interpretation in elderly subjects with suspected multiple sclerosis , 1988, Neurology.

[27]  D. Paty,et al.  A population-based study of multiple sclerosis in twins. , 1986, The New England journal of medicine.

[28]  W. L. Benedict,et al.  Multiple Sclerosis , 2007, Journal - Michigan State Medical Society.