THE EVOLUTION OF FIELD DEPLOYABLE fNIR SPECTROSCOPY FROM BENCH TO CLINICAL SETTINGS

In the late 1980s and early 1990s, Dr. Britton Chance and his colleagues, using picosecond-long laser pulses, spearheaded the development of time-resolved spectroscopy techniques in an effort to obtain quantitative information about the optical characteristics of the tissue. These efforts by Chance and colleagues expedited the translation of near-infrared spectroscopy (NIRS)-based techniques into a neuroimaging modality for various cognitive studies. Beginning in the early 2000s, Dr. Britton Chance guided and steered the collaboration with the Optical Brain Imaging team at Drexel University toward the development and application of a field deployable continuous wave functional near-infrared spectroscopy (fNIR) system as a means to monitor cognitive functions, particularly during attention and working memory tasks as well as for complex tasks such as war games and air traffic control scenarios performed by healthy volunteers under operational conditions. Further, these collaborative efforts led to various clinical applications, including traumatic brain injury, depth of anesthesia monitoring, pediatric pain assessment, and brain–computer interface in neurology. In this paper, we introduce how these collaborative studies have made fNIR an excellent candidate for specified clinical and research applications, including repeated cortical neuroimaging, bedside or home monitoring, the elicitation of a positive effect, and protocols requiring ecological validity. This paper represents a token of our gratitude to Dr. Britton Chance for his influence and leadership. Through this manuscript we show our appreciation by contributing to his commemoration and through our work we will strive to advance the field of optical brain imaging and promote his legacy.

[1]  Raymond D Pitetti.  Do no harm — but first, do not hurt , 2005, Canadian Medical Association Journal.

[2]  Britton Chance,et al.  Functional Optical Brain Imaging Using Near-Infrared During Cognitive Tasks , 2004, Int. J. Hum. Comput. Interact..

[3]  Hasan Ayaz,et al.  Optical brain monitoring for operator training and mental workload assessment , 2012, NeuroImage.

[4]  Richard Goldstein,et al.  Functional neuroimaging and cognitive rehabilitation for people with traumatic brain injury. , 2005, American journal of physical medicine & rehabilitation.

[5]  Theodore J. Huppert,et al.  Real-time imaging of human brain function by near-infrared spectroscopy using an adaptive general linear model , 2009, NeuroImage.

[6]  M. Bartels,et al.  Left prefrontal activation predicts therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) in major depression , 2000, Psychiatry Research: Neuroimaging.

[7]  F. Jöbsis.  Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. , 1977, Science.

[8]  Hasan Ayaz,et al.  Assessment of Cognitive Neural Correlates for a Functional Near Infrared-Based Brain Computer Interface System , 2009, HCI.

[9]  Niels Birbaumer,et al.  Brain–computer-interface research: Coming of age , 2006, Clinical Neurophysiology.

[10]  Tom Chau,et al.  Decoding subjective preference from single-trial near-infrared spectroscopy signals , 2009, Journal of neural engineering.

[11]  Janette Atkinson,et al.  Regional Hemodynamic Responses to Visual Stimulation in Awake Infants , 1998, Pediatric Research.

[12]  Thomas E. Myers,et al.  Functional near infrared spectroscopy reveals differences in self–other processing as a function of schizotypal personality traits , 2005, Schizophrenia Research.

[13]  Jonathan R Wolpaw,et al.  Brain–computer interfaces as new brain output pathways , 2007, The Journal of physiology.

[14]  Cuntai Guan,et al.  Temporal classification of multichannel near-infrared spectroscopy signals of motor imagery for developing a brain–computer interface , 2007, NeuroImage.

[15]  Shirley M Coyle,et al.  Brain–computer interface using a simplified functional near-infrared spectroscopy system , 2007, Journal of neural engineering.

[16]  Shirley Coyle,et al.  On the suitability of near-infrared (NIR) systems for next-generation brain-computer interfaces. , 2004, Physiological measurement.

[17]  M. Tamura,et al.  Impaired interhemispheric integration in brain oxygenation and hemodynamics in schizophrenia , 1993, Schizophrenia Research.

[18]  P. Goldman-Rakic,et al.  Infrequent events transiently activate human prefrontal and parietal cortex as measured by functional MRI. , 1997, Journal of neurophysiology.

[19]  S. Aalto,et al.  Effects of Sevoflurane, Propofol, and Adjunct Nitrous Oxide on Regional Cerebral Blood Flow, Oxygen Consumption, and Blood Volume in Humans , 2003, Anesthesiology.

[20]  S. Arridge,et al.  Estimation of optical pathlength through tissue from direct time of flight measurement , 1988 .

[21]  Andrew Newberg,et al.  Neuroimaging of traumatic brain injury. , 2008, Seminars in neurology.

[22]  D. Delpy,et al.  System for long-term measurement of cerebral blood and tissue oxygenation on newborn infants by near infra-red transillumination , 1988, Medical and Biological Engineering and Computing.

[23]  Hugo Lagercrantz,et al.  Pain activates cortical areas in the preterm newborn brain , 2006, PAIN.

[24]  M. van Dijk,et al.  Pain assessment: current status and challenges. , 2006, Seminars in fetal & neonatal medicine.

[25]  Sarah D Power,et al.  Classification of prefrontal activity due to mental arithmetic and music imagery using hidden Markov models and frequency domain near-infrared spectroscopy , 2010, Journal of neural engineering.

[26]  S. Bunce,et al.  Functional near-infrared neuroimaging , 2005, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[27]  S. Koelsch,et al.  The effects of anesthetics on brain activity and cognitive function , 2005, Current opinion in anaesthesiology.

[28]  A. Rosen,et al.  A portable near infrared spectroscopy system for bedside monitoring of newborn brain , 2005, Biomedical engineering online.

[29]  S. Petersen,et al.  Characterizing the Hemodynamic Response: Effects of Presentation Rate, Sampling Procedure, and the Possibility of Ordering Brain Activity Based on Relative Timing , 2000, NeuroImage.

[30]  J. DeLuca,et al.  Functionally Activated Brain Imaging (O‐15 PET and fMRI) in the Study of Learning and Memory after Traumatic Brain Injury , 2001, The Journal of head trauma rehabilitation.

[31]  Y. Katayama,et al.  Changes in cerebral blood oxygenation of the frontal lobe induced by direct electrical stimulation of thalamus and globus pallidus: a near infrared spectroscopy study , 1999, Journal of neurology, neurosurgery, and psychiatry.

[32]  E Gratton,et al.  Propagation of photon-density waves in strongly scattering media containing an absorbing semi-infinite plane bounded by a straight edge. , 1993, Journal of the Optical Society of America. A, Optics and image science.

[33]  Gert Pfurtscheller,et al.  Development, set-up and first results for a one-channel near-infrared spectroscopy system / Entwicklung, Aufbau und vorläufige Ergebnisse eines Einkanal- Nahinfrarot-Spektroskopie-Systems , 2008, Biomedizinische Technik. Biomedical engineering.

[34]  A. Fallgatter,et al.  Reduced frontal functional asymmetry in schizophrenia during a cued continuous performance test assessed with near-infrared spectroscopy. , 2000, Schizophrenia bulletin.

[35]  D. Boas,et al.  Three dimensional Monte Carlo code for photon migration through complex heterogeneous media including the adult human head. , 2002, Optics express.

[36]  P. Zaramella,et al.  Brain Auditory Activation Measured by Near-Infrared Spectroscopy (NIRS) in Neonates , 2001, Pediatric Research.

[37]  B. Chance,et al.  A novel method for fast imaging of brain function, non-invasively, with light. , 1998, Optics express.

[38]  A. Villringer,et al.  Near Infrared Spectroscopy in the Diagnosis of Alzheimer's Disease a , 1996, Annals of the New York Academy of Sciences.

[39]  A Villringer,et al.  Near-infrared spectroscopy in functional activation studies. Can NIRS demonstrate cortical activation? , 1997, Advances in experimental medicine and biology.

[40]  B. Matta,et al.  Direct cerebral vasodilatory effects of sevoflurane and isoflurane. , 1999, Anesthesiology.

[41]  Waldemar Karwowski,et al.  Advances in Understanding Human Performance : Neuroergonomics, Human Factors Design, and Special Populations , 2010 .

[42]  J. Y. Kao,et al.  Cerebral metabolism during propofol anesthesia in humans studied with positron emission tomography. , 1995 .

[43]  Jonathan G. Hardman,et al.  Cerebral Hemodynamic Response to the Introduction of Desflurane: A Comparison with Sevoflurane , 2000 .

[44]  A. Villringer,et al.  Non-invasive optical spectroscopy and imaging of human brain function , 1997, Trends in Neurosciences.

[45]  Hasan Ayaz,et al.  Using MazeSuite and Functional Near Infrared Spectroscopy to Study Learning in Spatial Navigation , 2011, Journal of visualized experiments : JoVE.

[46]  Y. Tokumitsu,et al.  Dominance of the 'nondominant' hemisphere in depression. , 1996, Journal of affective disorders.

[47]  Harvey S. Levin,et al.  Altered Brain Activation During Cognitive Control in Patients With Moderate to Severe Traumatic Brain Injury , 2007, Neurorehabilitation and neural repair.

[48]  B. Wilson,et al.  Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. , 1989, Applied optics.

[49]  E. Watanabe,et al.  Noninvasive cerebral blood volume measurement during seizures using multichannel near infrared spectroscopic topography. , 1998, Journal of biomedical optics.