Induction of COX-2/PGE(2)/IL-6 is crucial for cigarette smoke extract-induced airway inflammation: Role of TLR4-dependent NADPH oxidase activation.

[1]  H. Hsieh,et al.  Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1, and NF-κB in human tracheal smooth muscle cells , 2009 .

[2]  K. Kubo,et al.  Enhanced levels of prostaglandin E2 and matrix metalloproteinase‐2 correlate with the severity of airflow limitation in stable COPD , 2008, Respirology.

[3]  M. Bonsignore,et al.  Cigarette smoke increases Toll‐like receptor 4 and modifies lipopolysaccharide‐mediated responses in airway epithelial cells , 2008, Immunology.

[4]  H. Kita,et al.  Nicotine and oxidative cigarette smoke constituents induce immune-modulatory and pro-inflammatory dendritic cell responses. , 2008, Molecular immunology.

[5]  V. Lagente,et al.  OXIDATIVE STRESS IS AN IMPORTANT COMPONENT OF AIRWAY INFLAMMATION IN MICE EXPOSED TO CIGARETTE SMOKE OR LIPOPOLYSACCHARIDE , 2008, Clinical and experimental pharmacology & physiology.

[6]  D. Pearse,et al.  Upregulation of cortical COX-2 in salt-sensitive hypertension: role of angiotensin II and reactive oxygen species. , 2008, American journal of physiology. Renal physiology.

[7]  T. Scott,et al.  Thrombocytes respond to lipopolysaccharide through Toll-like receptor-4, and MAP kinase and NF-kappaB pathways leading to expression of interleukin-6 and cyclooxygenase-2 with production of prostaglandin E2. , 2008, Molecular immunology.

[8]  Tomoaki Koga,et al.  Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B , 2008, Respiratory research.

[9]  B. Ryffel,et al.  Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent1 , 2008, The Journal of Immunology.

[10]  Y. Son,et al.  Roles of MAPK and NF-κB in Interleukin-6 Induction by Lipopolysaccharide in Vascular Smooth Muscle Cells , 2008, Journal of cardiovascular pharmacology.

[11]  I. Rahman,et al.  Redox regulation of lung inflammation: role of NADPH oxidase and NF-kappaB signalling. , 2007, Biochemical Society transactions.

[12]  H. Nishikawa,et al.  Inhibition of NADPH oxidase subunits translocation by tea catechin EGCG in mast cell. , 2007, Biochemical and biophysical research communications.

[13]  B. Chandran,et al.  Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells. , 2007, Cellular signalling.

[14]  N. Nagaraj,et al.  Cigarette smoke condensate increases cathepsin-mediated invasiveness of oral carcinoma cells. , 2007, Toxicology letters.

[15]  B. Ryffel,et al.  TLR4 gene dosage contributes to endotoxin‐induced acute respiratory inflammation , 2006, Journal of leukocyte biology.

[16]  I. Adcock,et al.  Oxidative stress and redox regulation of lung inflammation in COPD , 2006, European Respiratory Journal.

[17]  Chien-Huang Lin,et al.  Peptidoglycan-Induced IL-6 Production in RAW 264.7 Macrophages Is Mediated by Cyclooxygenase-2, PGE2/PGE4 Receptors, Protein Kinase A, IκB Kinase, and NF-κB1 , 2006, The Journal of Immunology.

[18]  R. Pauwels,et al.  Murine models of COPD. , 2006, Pulmonary pharmacology & therapeutics.

[19]  S. Abramson,et al.  Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases. , 2006, Clinical immunology.

[20]  J. Pouysségur,et al.  Transcriptional regulation of VCAM‐1 expression by tumor necrosis factor‐α in human tracheal smooth muscle cells: Involvement of MAPKs, NF‐κB, p300, and histone acetylation , 2006 .

[21]  Zhengfan Jiang,et al.  Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. , 2006, Annual review of immunology.

[22]  A. Jones,et al.  Induction of apoptosis with tobacco smoke and related products in A549 lung epithelial cells in vitro , 2006, Journal of Inflammation.

[23]  M. Inouye,et al.  Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice. , 2006, American journal of respiratory and critical care medicine.

[24]  P. Sime,et al.  The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[25]  V. Kinnula.  Focus on antioxidant enzymes and antioxidant strategies in smoking related airway diseases , 2005, Thorax.

[26]  N. Parinandi,et al.  Src-mediated Tyrosine Phosphorylation of p47phox in Hyperoxia-induced Activation of NADPH Oxidase and Generation of Reactive Oxygen Species in Lung Endothelial Cells* , 2005, Journal of Biological Chemistry.

[27]  R. Roskoski,et al.  Src kinase regulation by phosphorylation and dephosphorylation. , 2005, Biochemical and biophysical research communications.

[28]  M. Christie,et al.  Acute Tumor Necrosis Factor Alpha Signaling via NADPH Oxidase in Microvascular Endothelial Cells: Role of p47phox Phosphorylation and Binding to TRAF4 , 2005, Molecular and Cellular Biology.

[29]  Jaw-Town Lin,et al.  Induction of Cyclooxygenase-2 Overexpression in Human Gastric Epithelial Cells by Helicobacter pylori Involves TLR2/TLR9 and c-Src-Dependent Nuclear Factor-κB Activation , 2004, Molecular Pharmacology.

[30]  I. Rahman,et al.  Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression. , 2004, Biochemical pharmacology.

[31]  Y. Surh,et al.  Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. , 2004, Biochemical pharmacology.

[32]  P. Howarth,et al.  Synthetic responses in airway smooth muscle. , 2004, The Journal of allergy and clinical immunology.

[33]  C. G. McVicker,et al.  Proliferative aspects of airway smooth muscle. , 2004, The Journal of allergy and clinical immunology.

[34]  E. Tremoli,et al.  Apocynin prevents cyclooxygenase 2 expression in human monocytes through NADPH oxidase and glutathione redox-dependent mechanisms. , 2004, Free radical biology & medicine.

[35]  Shizuo Akira,et al.  Toll-like receptor signalling , 2004, Nature Reviews Immunology.

[36]  S. Lario,et al.  Cigarette smoke concentrate increases 8-epi-PGF2α and TGFβ1 secretion in rat mesangial cells , 2004 .

[37]  E. Schiffrin,et al.  Angiotensin II and endothelin-1 regulate MAP kinases through different redox-dependent mechanisms in human vascular smooth muscle cells , 2004, Journal of hypertension.

[38]  Chuen-Mao Yang,et al.  Lipoteichoic acid-stimulated p42/p44 MAPK activation via Toll-like receptor 2 in tracheal smooth muscle cells. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[39]  Chih‐Chung Lin,et al.  Tumor necrosis factor-α-induced cyclooxygenase-2 expression in human tracheal smooth muscle cells : involvement of p42/p44 and p38 mitogen-activated protein kinases and nuclear factor-κB , 2004 .

[40]  W. Yeh,et al.  IRAK-4 as the central TIR signaling mediator in innate immunity. , 2002, Trends in immunology.

[41]  J. Hasday,et al.  Bacterial endotoxin is an active component of cigarette smoke. , 1999, Chest.

[42]  H. Pahl,et al.  The Anti-inflammatory Sesquiterpene Lactone Helenalin Inhibits the Transcription Factor NF-κB by Directly Targeting p65* , 1998, The Journal of Biological Chemistry.

[43]  S. Boyce,et al.  Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach. , 1995, The Journal of pharmacology and experimental therapeutics.

[44]  W. Pryor,et al.  Oxidants in Cigarette Smoke Radicals, Hydrogen Peroxide, Peroxynitrate, and Peroxynitrite a , 1993, Annals of the New York Academy of Sciences.

[45]  J. Samet,et al.  Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells. , 2009, American journal of respiratory cell and molecular biology.

[46]  K. Krause,et al.  The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. , 2007, Physiological reviews.

[47]  Y. Yamaguchi,et al.  Oxidants in the gas phase of cigarette smoke pass through the lung alveolar wall and raise systemic oxidative stress. , 2007, Journal of pharmacological sciences.

[48]  H. Forman,et al.  Redox signaling and the MAP kinase pathways , 2003, BioFactors.