Molecularly imprinted polymers: new tailor-made materials for selective solid-phase extraction

Solid-phase extraction (SPE) materials are a promising and innovative application of molecularly imprinted polymers (MIPs). These polymers allow certain analytes to be selectively extracted from complex matrices without matrix interference. The applications described in this article include the molecularly imprinted SPE (MISPE) of several kinds of analytes of biological, pharmaceutical and environmental interest. To ensure selectivity emphasis is placed on synthetic considerations and the various steps in the extraction process. Finally, we also report on recent advances in this technique.

[1]  E. Lai,et al.  Rapid determination of theophylline in serum by selective extraction using a heated molecularly imprinted polymer micro-column with differential pulsed elution. , 1999, Journal of pharmaceutical and biomedical analysis.

[2]  B. Sellergren,et al.  Analysis of nicotine and its oxidation products in nicotine chewing gum by a molecularly imprinted solid-phase extraction. , 1998, Analytical chemistry.

[3]  B. Sellergren,et al.  Method for synthesis and screening of large groups of molecularly imprinted polymers. , 1999, Analytical chemistry.

[4]  B. Sellergren,et al.  Selective trace enrichment of chlorotriazine pesticides from natural waters and sediment samples using terbuthylazine molecularly imprinted polymers , 2000, Analytical chemistry.

[5]  D. Stevenson.  Molecular imprinted polymers for solid-phase extraction , 1999 .

[6]  O. Ramström,et al.  On-line solid-phase extraction of triazine herbicides using a molecularly imprinted polymer for selective sample enrichment. , 1999, Analytical chemistry.

[7]  D. Barceló,et al.  Validation of new solid-phase extraction materials for the selective enrichment of organic contaminants from environmental samples , 1999 .

[8]  I. Wilson,et al.  Optimisation of procedures for the extraction of structural analogues of propranolol with molecular imprinted polymers for sample preparation. , 2000, Journal of Chromatography A.

[9]  Toshifumi Takeuchi,et al.  Solid-phase Extraction of a Triazine Herbicide Using a Molecularly Imprinted Synthetic Receptor , 1997 .

[10]  P. K. Owens,et al.  Molecular imprinting for bio- and pharmaceutical analysis , 1999 .

[11]  D. Sherrington,et al.  Synthesis and evaluation of a molecularly imprinted polymer for selective on-line solid-phase extraction of 4-nitrophenol from environmental water. , 2000, Analytical chemistry.

[12]  R. Venn,et al.  Synthesis and properties of molecular imprints of darifenacin: The potential of molecular imprinting for bioanalysis , 1999 .

[13]  C. Cámara,et al.  Immunosorbents: A new tool for pesticide sample handling in environmental analysis , 1997 .

[14]  J Howarth,et al.  The preparation of a molecular imprinted polymer to 7-hydroxycoumarin and its use as a solid-phase extraction material. , 1997, Journal of pharmaceutical and biomedical analysis.

[15]  B. Sellergren,et al.  Direct Drug Determination by Selective Sample Enrichment on an Imprinted Polymer , 1994 .

[16]  Ian D. Wilson,et al.  Evaluation of a Molecular-imprinted Polymer for use in the Solid Phase Extraction of Propranolol From Biological Fluids , 1997 .

[17]  L. Andersson,et al.  Efficient sample pre-concentration of bupivacaine from human plasma by solid-phase extraction on molecularly imprinted polymers. , 2000, The Analyst.

[18]  D. Barceló,et al.  Isolation of priority polycyclic aromatic hydrocarbons from natural sediments and sludge reference materials by an anti-fluorene immunosorbent followed by liquid chromatography and diode array detection. , 1998, Analytical chemistry.

[19]  Claudio Baggiani,et al.  A molecularly imprinted polymer for the pesticide bentazone , 1999 .

[20]  Takeuchi,et al.  Atrazine-selective polymers prepared by molecular imprinting of trialkylmelamines as dummy template species of atrazine , 2000, Analytical chemistry.

[21]  K. Hosoya,et al.  Porogen Imprinting Effects , 1998 .

[22]  E. Lai,et al.  Determination of theophylline in serum by molecularly imprinted solid-phase extraction with pulsed elution. , 1998, Analytical chemistry.

[23]  C. Miège,et al.  Immunosorbents: natural molecular recognition materials for sample preparation of complex environmental matrices , 1999 .

[24]  J. Matsui,et al.  Solid-phase extraction with a dibutylmelamine-imprinted polymer as triazine herbicide-selective sorbent. , 2000, Journal of chromatography. A.

[25]  I. Wilson,et al.  Methodology for assessing the properties of molecular imprinted polymers for solid phase extraction , 1999 .

[26]  Toshifumi Takeuchi,et al.  Application of indoleacetic acid-imprinted polymer to solid phase extraction , 1999 .

[27]  B. Sellergren.  Polymer- and template-related factors influencing the efficiency in molecularly imprinted solid-phase extractions , 1999 .

[28]  D. Sherrington,et al.  Use of molecularly imprinted solid-phase extraction for the selective clean-up of clenbuterol from calf urine. , 2000, Journal of chromatography. A.

[29]  M. Muldoon,et al.  Molecularly imprinted solid phase extraction of atrazine from beef liver extracts. , 1997, Analytical chemistry.

[30]  K. Mosbach,et al.  Molecularly imprinted polymers and their use in biomimetic sensors. , 2000, Chemical reviews.

[31]  L. I. Andersson,et al.  A highly selective solid phase extraction sorbent for pre-concentration of sameridine made by molecular imprinting , 1997 .

[32]  Edward P. C. Lai,et al.  Determination of nicotine in tobacco by molecularly imprinted solid phase extraction with differential pulsed elution , 1999 .

[33]  K. Ensing.  Tailor-made materials for tailor-made applications: application of molecular imprints in chemical analysis , 1999 .

[34]  Xiwen He,et al.  A 2-aminopyridine molecularly imprinted polymer surrogate micro-column for selective solid phase extraction and determination of 4-aminopyridine , 2000 .

[35]  D. Stevenson,et al.  Preliminary Evaluation of a Molecular Imprinted Polymer for Solid-phase Extraction of Tamoxifen , 1997 .