Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau

[1]  Elena M. Vazey,et al.  Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART , 2023, Alzheimer's & dementia : the journal of the Alzheimer's Association.

[2]  T. Hökfelt,et al.  Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus–pericoerulear complex by three-dimensional imaging , 2022, Acta Neuropathologica.

[3]  K. Blennow,et al.  Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer’s disease , 2022, Nature Medicine.

[4]  Justin S. Sanchez,et al.  Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease , 2022, Alzheimer's & dementia : the journal of the Alzheimer's Association.

[5]  H. Zetterberg.  Biofluid‐based biomarkers for Alzheimer's disease–related pathologies: An update and synthesis of the literature , 2022, Alzheimer's & dementia : the journal of the Alzheimer's Association.

[6]  K. Blennow,et al.  Plasma biomarkers for Alzheimer’s Disease in relation to neuropathology and cognitive change , 2022, Acta Neuropathologica.

[7]  Christine L. Tardif,et al.  Association of locus coeruleus integrity with Braak stage and neuropsychiatric symptom severity in Alzheimer’s disease , 2022, Neuropsychopharmacology.

[8]  K. Blennow,et al.  Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240 tau-PET , 2022, EBioMedicine.

[9]  K. Blennow,et al.  Plasma p‐tau231, p‐tau181, PET Biomarkers, and Cognitive Change in Older Adults , 2022, Annals of neurology.

[10]  D. Minhas,et al.  Direct Comparison of the Tau PET Tracers 18F-Flortaucipir and 18F-MK-6240 in Human Subjects , 2021, The Journal of Nuclear Medicine.

[11]  Briana L. Kennedy,et al.  Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer’s disease , 2020, Neurobiology of Aging.

[12]  H. Jacobs,et al.  Associations between locus coeruleus integrity and nocturnal awakenings in the context of Alzheimer’s disease plasma biomarkers: a 7T MRI study , 2021, Alzheimer's research & therapy.

[13]  Justin S. Sanchez,et al.  In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline , 2021, Science Translational Medicine.

[14]  C. Jack,et al.  Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive Outcomes. , 2021, JAMA neurology.

[15]  K. Blennow,et al.  Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology , 2021, Acta Neuropathologica.

[16]  A. Dale,et al.  MRI‐assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction , 2021, Alzheimer's & dementia : the journal of the Alzheimer's Association.

[17]  Justin S. Sanchez,et al.  The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography , 2021, Science Translational Medicine.

[18]  M. Mather,et al.  Locus coeruleus MRI contrast is associated with cortical thickness in older adults , 2020, Neurobiology of Aging.

[19]  K. Blennow,et al.  Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology are detected , 2020, EMBO molecular medicine.

[20]  O. Hansson,et al.  Associations of Plasma Phospho-Tau217 Levels With Tau Positron Emission Tomography in Early Alzheimer Disease , 2020, JAMA neurology.

[21]  D. Walsh,et al.  Longitudinal plasma p-tau217 is increased in early stages of Alzheimer’s disease , 2020, Brain : a journal of neurology.

[22]  E. Mandelkow,et al.  Disease‐Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates , 2020, Angewandte Chemie.

[23]  S. Foote,et al.  Locus coeruleus: a new look at the blue spot , 2020, Nature Reviews Neuroscience.

[24]  T. Robbins,et al.  Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease , 2020, medRxiv.

[25]  K. Uludağ,et al.  Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm , 2020, eLife.

[26]  Nick C Fox,et al.  A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease , 2020, Nature Medicine.

[27]  K. Blennow,et al.  Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia , 2020, Nature Medicine.

[28]  K. Blennow,et al.  Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration , 2020, Nature Medicine.

[29]  Simone Kühn,et al.  Rostral locus coeruleus integrity is associated with better memory performance in older adults , 2019, Nature Human Behaviour.

[30]  Oliver Speck,et al.  Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases , 2019, Brain : a journal of neurology.

[31]  D. Ehrnhoefer,et al.  A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer’s disease brain , 2019, Acta Neuropathologica Communications.

[32]  Keith A. Johnson,et al.  Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue , 2019, Acta neuropathologica communications.

[33]  Dag Aarsland,et al.  Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration , 2019, Acta neuropathologica communications.

[34]  K. Blennow,et al.  Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer’s disease , 2018, Alzheimer's Research & Therapy.

[35]  David A Bennett,et al.  Religious Orders Study and Rush Memory and Aging Project. , 2018, Journal of Alzheimer's disease : JAD.

[36]  Simone Kühn,et al.  Higher rostral locus coeruleus integrity is associated with better memory performance in older adults , 2018 .

[37]  Keith A. Johnson,et al.  Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals , 2018, Nature Neuroscience.

[38]  Jorge Sepulcre,et al.  Structural tract alterations predict down-stream tau accumulation in amyloid positive older individuals , 2018, Nature Neuroscience.

[39]  Dimo Ivanov,et al.  High-resolution in vivo imaging of human locus coeruleus by magnetization transfer MRI at 3T and 7T , 2017, NeuroImage.

[40]  Keith A. Johnson,et al.  18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal. , 2018, Journal of Alzheimer's disease : JAD.

[41]  R. Sperling,et al.  Optimizing the preclinical Alzheimer's cognitive composite with semantic processing: The PACC5 , 2017, Alzheimer's & dementia.

[42]  D. Weinshenker,et al.  Down but Not Out: The Consequences of Pretangle Tau in the Locus Coeruleus , 2017, Neural plasticity.

[43]  L. Grinberg,et al.  Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease , 2017, Neuropathology and applied neurobiology.

[44]  J. Neuhaus,et al.  Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery , 2017, Alzheimer's & Dementia.

[45]  Denise C. Park,et al.  Amyloid deposition in younger adults is linked to episodic memory performance , 2016, Neurology.

[46]  G. Aston-Jones,et al.  Locus coeruleus: From global projection system to adaptive regulation of behavior , 2016, Brain Research.

[47]  L. Luo,et al.  Organization of the Locus Coeruleus-Norepinephrine System , 2015, Current Biology.

[48]  Keith A. Johnson,et al.  Validating novel tau positron emission tomography tracer [F‐18]‐AV‐1451 (T807) on postmortem brain tissue , 2015, Annals of neurology.

[49]  H. Braak,et al.  PART is part of Alzheimer disease , 2015, Acta Neuropathologica.

[50]  Keith A. Johnson,et al.  The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials , 2014, Neuron.

[51]  B. Waterhouse,et al.  Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices , 2014, Proceedings of the National Academy of Sciences.

[52]  J. Karlawish,et al.  The A4 Study: Stopping AD Before Symptoms Begin? , 2014, Science Translational Medicine.

[53]  J. Schneider,et al.  Neural reserve, neuronal density in the locus ceruleus, and cognitive decline , 2013, Neurology.

[54]  H. Braak,et al.  Where, when, and in what form does sporadic Alzheimer's disease begin? , 2012, Current opinion in neurology.

[55]  David A Bennett,et al.  Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease , 2012, Movement disorders : official journal of the Movement Disorder Society.

[56]  J. Schneider,et al.  Overview and findings from the rush Memory and Aging Project. , 2012, Current Alzheimer research.

[57]  A. Gonçalves-Ferreira,et al.  The human locus coeruleus 3-D stereotactic anatomy , 2012, Surgical and Radiologic Anatomy.

[58]  Dietmar R. Thal,et al.  Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years , 2011, Journal of neuropathology and experimental neurology.

[59]  C. Jack,et al.  Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade , 2010, The Lancet Neurology.

[60]  Tobias Kober,et al.  MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field , 2010, NeuroImage.

[61]  E. Szabadi,et al.  Functional Neuroanatomy of the Noradrenergic Locus Coeruleus: Its Roles in the Regulation of Arousal and Autonomic Function Part I: Principles of Functional Organisation , 2008, Current neuropharmacology.

[62]  David A. Bennett,et al.  Decision Rules Guiding the Clinical Diagnosis of Alzheimer’s Disease in Two Community-Based Cohort Studies Compared to Standard Practice in a Clinic-Based Cohort Study , 2006, Neuroepidemiology.

[63]  J. Schneider,et al.  Neuropathology of older persons without cognitive impairment from two community-based studies , 2006, Neurology.

[64]  D. A. Bennett,et al.  Natural history of mild cognitive impairment in older persons , 2002, Neurology.

[65]  Anders M. Dale,et al.  Cortical Surface-Based Analysis I. Segmentation and Surface Reconstruction , 1999, NeuroImage.

[66]  John Q. Trojanowski,et al.  Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease , 1997, Neurobiology of Aging.

[67]  L Carlin,et al.  Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease. , 1995, Archives of neurology.

[68]  Wade K. Smith,et al.  Disease‐specific patterns of locus coeruleus cell loss , 1992, Annals of neurology.

[69]  V. Chan‐Palay,et al.  Quantitation of catecholamine neurons in the locus coeruleus in human brains of normal young and older adults and in depression , 1989, The Journal of comparative neurology.

[70]  F. Bloom,et al.  Efferent projections of nucleus locus coeruleus: Topographic organization of cells of origin demonstrated by three-dimensional reconstruction , 1986, Neuroscience.