Coffee and tea consumption, genotype‐based CYP1A2 and NAT2 activity and colorectal cancer risk—Results from the EPIC cohort study

Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. Data from 477,071 participants (70.2% female) of the European Investigation into Cancer and Nutrition (EPIC) cohort study were analyzed. At baseline (1992–2000) habitual (total, caffeinated and decaffeinated) coffee and tea consumption was assessed with dietary questionnaires. Cox proportional hazards models were used to estimate adjusted hazard ratio's (HR) and 95% confidence intervals (95% CI). Potential effect modification by genotype‐based CYP1A2 and NAT2 activity was studied in a nested case–control set of 1,252 cases and 2,175 controls. After a median follow‐up of 11.6 years, 4,234 participants developed CRC (mean age 64.7 ± 8.3 years). Total coffee consumption (high vs. non/low) was not associated with CRC risk (HR 1.06, 95% CI 0.95–1.18) or subsite cancers, and no significant associations were found for caffeinated (HR 1.10, 95% CI 0.97–1.26) and decaffeinated coffee (HR 0.96, 95% CI 0.84–1.11) and tea (HR 0.97, 95% CI 0.86–1.09). High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non/low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity, which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk. This study shows that coffee and tea consumption is not likely to be associated with overall CRC.

[1]  S. Gruber,et al.  Coffee Consumption and the Risk of Colorectal Cancer , 2016, Cancer Epidemiology, Biomarkers & Prevention.

[2]  R. Hayes,et al.  Prospective study of the relationship between coffee and tea with colorectal cancer risk: The PLCO Cancer Screening Trial , 2013, British Journal of Cancer.

[3]  R. Sinha,et al.  Caffeinated and decaffeinated coffee and tea intakes and risk of colorectal cancer in a large prospective study. , 2012, The American journal of clinical nutrition.

[4]  Tanya M. Teslovich,et al.  The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits , 2012, PLoS genetics.

[5]  Yumei Zhang,et al.  Coffee consumption and risk of colorectal cancer: a meta-analysis of observational studies , 2012, Public Health Nutrition.

[6]  廣畑 富雄,et al.  Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective , 2007 .

[7]  M. Doll,et al.  Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes. , 2012, Pharmacogenomics.

[8]  M. Medina,et al.  Correction: Anti-Angiogenic and Anti-Inflammatory Properties of Kahweol, a Coffee Diterpene , 2011, PLoS ONE.

[9]  M. Medina,et al.  Anti-Angiogenic and Anti-Inflammatory Properties of Kahweol, a Coffee Diterpene , 2011, PloS one.

[10]  A. Braillon.  European Prospective Investigation into Cancer and Nutrition (EPIC): methods and clinical relevance. , 2011, The American journal of clinical nutrition.

[11]  Heiying Jin,et al.  The study of effect of tea polyphenols on microsatellite instability colorectal cancer and its molecular mechanism , 2010, International Journal of Colorectal Disease.

[12]  W. Willett,et al.  Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: pooled analysis of prospective cohort studies. , 2010, Journal of the National Cancer Institute.

[13]  S. Janković,et al.  Induction of CYP1A2 by heavy coffee consumption is associated with the CYP1A2 −163C>A polymorphism , 2010, European Journal of Clinical Pharmacology.

[14]  R. Goldbohm,et al.  Fluid Intake and Colorectal Cancer Risk in the Netherlands Cohort Study , 2010, Nutrition and cancer.

[15]  Jian-Min Yuan,et al.  Coffee Intake and Risk of Colorectal Cancer Among Chinese in Singapore: The Singapore Chinese Health Study , 2009, Nutrition and cancer.

[16]  A. Gunes,et al.  Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms. , 2008, Pharmacogenomics.

[17]  R. Schulte‐Hermann,et al.  Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[18]  S. Janković,et al.  Induction of CYP1A2 by heavy coffee consumption in Serbs and Swedes , 2008, European Journal of Clinical Pharmacology.

[19]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[20]  K. Varani,et al.  Caffeine Inhibits Adenosine-Induced Accumulation of Hypoxia-Inducible Factor-1α, Vascular Endothelial Growth Factor, and Interleukin-8 Expression in Hypoxic Human Colon Cancer Cells , 2007, Molecular Pharmacology.

[21]  David E. Williams,et al.  Comparison of White Tea, Green Tea, Epigallocatechin-3-Gallate, and Caffeine as Inhibitors of PhIP-Induced Colonic Aberrant Crypts , 2007, Nutrition and cancer.

[22]  S. Kuriyama,et al.  Coffee consumption and the risk of colorectal cancer: A prospective cohort study in Japan , 2007, International journal of cancer.

[23]  E. Riboli,et al.  The second expert report, Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective , 2007 .

[24]  N. Habermann,et al.  Bread Enriched With Green Coffee Extract Has Chemoprotective and Antigenotoxic Activities in Human Cells , 2006, Nutrition and cancer.

[25]  Jian-Min Yuan,et al.  Green tea, black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies. , 2006, Carcinogenesis.

[26]  B. Frei,et al.  Coffee and Health: A Review of Recent Human Research , 2006, Critical reviews in food science and nutrition.

[27]  W. Willett,et al.  Coffee, tea, and caffeine consumption and incidence of colon and rectal cancer. , 2005, Journal of the National Cancer Institute.

[28]  S. Okamura,et al.  The effects of coffee on conjugation reactions in human colon carcinoma cells. , 2005, Biological & pharmaceutical bulletin.

[29]  W. Parzefall,et al.  Modification of N-acetyltransferases and glutathione S-transferases by coffee components: possible relevance for cancer risk. , 2005, Methods in enzymology.

[30]  J. Shaddock,et al.  Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N‐acetyltransferase and glutathione S‐transferase activities , 2004, Environmental and molecular mutagenesis.

[31]  B. Frei,et al.  Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions , 2003, Critical reviews in food science and nutrition.

[32]  N E Day,et al.  European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection , 2002, Public Health Nutrition.

[33]  A. Constable,et al.  Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity. , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[34]  B. Berra,et al.  Dietary sphingolipids in colorectal cancer prevention. , 2002, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[35]  M. Doll,et al.  Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms. , 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[36]  G. Yang,et al.  Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. , 1998, Carcinogenesis.

[37]  H. Princen,et al.  Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase in rat hepatocytes. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[38]  F. Kadlubar,et al.  Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat. , 1997, Mutation research.

[39]  P. Pietinen,et al.  European Prospective Investigation into Cancer and Nutrition: validity studies on dietary assessment methods. , 1997, International journal of epidemiology.

[40]  E Riboli,et al.  The EPIC Project: rationale and study design. European Prospective Investigation into Cancer and Nutrition. , 1997, International journal of epidemiology.

[41]  H. Schut,et al.  Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat. , 1996, Carcinogenesis.

[42]  R. Hayes,et al.  Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites. , 1992, Pharmacogenetics.

[43]  F. Gonzalez,et al.  Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1. , 1992, Pharmacogenetics.

[44]  N. Read,et al.  Effect of coffee on distal colon function. , 1990, Gut.

[45]  P. Trott,et al.  International Classification of Diseases for Oncology , 1977 .