Concurrent juvenile myelomonocytic leukemia and T‐lymphoblastic lymphoma with a shared missense mutation in NRAS

Single cases of B‐ and T‐lymphoblastic leukemia/lymphoma occurring after remission of JMML, and JMML occurring after remission of B‐lymphoblastic leukemia have been reported in the literature. We present a unique case of a child with concurrent JMML and T‐lymphoblastic lymphoma in which an identical missense mutation in NRAS was found in both the neoplastic JMML and T‐LBL cells. JMML has been considered a stem cell disorder, and our case provides additional molecular evidence for a stem cell lesion underlying the two different disease phenotypes. Pediatr Blood Cancer 2014;61:946–948. © 2013 Wiley Periodicals, Inc.

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