Acoustic Analysis of Voices of Patients with Neurologic Disease: Rationale and Preliminary Data

This paper presents a rationale for acoustic analysis of voices of neurologically diseased patients, and reports preliminary data from patients with myotonic dystrophy, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis, as well as from individuals at risk for Huntington's disease. Noninvasive acoustic analysis may be of clinical value to the otolaryngologist, neurologist, and speech pathologist for early and differential diagnosis and for documenting disease progression in these various neurologic disorders.

[1]  Gary Weismer,et al.  Acoustic Descriptions of Dysarthric Speech: Perceptual Correlates and Physiological Inferences , 1984 .

[2]  A. Young,et al.  A polymorphic DNA marker genetically linked to Huntington's disease , 1983, Nature.

[3]  B. Gerratt,et al.  Glottographic Measurement of Vocal Dysfunction , 1983, The Annals of otology, rhinology, and laryngology.

[4]  Y. Koike Vowel amplitude modulations in patients with laryngeal diseases. , 1969, The Journal of the Acoustical Society of America.

[5]  I. Titze Parameterization of the glottal area, glottal flow, and vocal fold contact area. , 1984, The Journal of the Acoustical Society of America.

[6]  M. Stoicheff Speaking fundamental frequency characteristics of nonsmoking female adults. , 1981, Journal of speech and hearing research.

[7]  L. Ramig,et al.  Acoustic Analyses of Phonation in Patients with Huntington's Disease , 1986, The Annals of otology, rhinology, and laryngology.

[8]  J. Antel,et al.  Amyotrophic lateral sclerosis: current concepts. , 1981, Postgraduate medicine.

[9]  R. F. Neiman,et al.  Myasthenia gravis focal to the larynx. Report of a case. , 1975, A M A Archives of Otolaryngology.

[10]  M. Hayden,et al.  Huntington’s Chorea , 1981, Springer London.

[11]  Dworkin Jp,et al.  Progressive speech deterioration and dysphagia in amyotrophic lateral sclerosis: case report. , 1979 .

[12]  Denis Williams,et al.  TEXTBOOK OF NEUROLOGY , 1960 .

[13]  L. Ramig,et al.  Effects of physiological aging on selected acoustic characteristics of voice. , 1983, Journal of speech and hearing research.

[14]  W. Leuchter,et al.  Voice Spectrography in the Evaluation of Myasthenia Gravis of the Larynx , 1978, The Annals of otology, rhinology, and laryngology.

[15]  D. Hartman Neurogenic Dysphonia , 1984, The Annals of otology, rhinology, and laryngology.

[16]  B. Gerratt,et al.  Cinegraphic observations of laryngeal function in parkinson's disease , 1984, The Laryngoscope.

[17]  T. Baer,et al.  Harmonics-to-noise ratio as an index of the degree of hoarseness. , 1982, The Journal of the Acoustical Society of America.

[18]  A. Eberstein,et al.  Electrodiagnosis of neuromuscular diseases , 1977 .