To enhance the active safety performance for automated electric vehicles (AEVs) at driving limits, the collaborative control of four-wheel steering (4WS) and direct yaw-moment control (DYC) is adopted. To deal with external disturbance and modeling error, Tube-based model predictive control (MPC) is applied to the control algorithm design, which takes the improvement of handling stability and path tracking performance into considerations. Taking the constraints into account, including control vector constraints, lateral stability constraints, rollover prevention constraints and path tracking error constraints, the integrated controller is designed and worked out by addressing the optimization issue. To verify the effectiveness and feasibility of the integrated controller, two extreme driving conditions are conducted based on hardware-in-the-loop (HIL) tests. Test results indicate that the integrated controller can improve vehicle’s handling stability and path tracking performance in unison at driving limits. Besides, the integrated controller shows strong robustness in the extreme conditions.