A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure.

[1]  Djordje M. Nedic,et al.  Modeling the Actin.myosin ATPase Cross-Bridge Cycle for Skeletal and Cardiac Muscle Myosin Isoforms. , 2017, Biophysical journal.

[2]  Joseph M. Muretta,et al.  Heart failure drug changes the mechanoenzymology of the cardiac myosin powerstroke , 2017, Proceedings of the National Academy of Sciences.

[3]  J. Spudich,et al.  Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin. , 2016, Cell reports.

[4]  J. Seidman,et al.  The Muscle-Bound Heart. , 2016, Cardiac electrophysiology clinics.

[5]  J. Spudich,et al.  Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin , 2016, Journal of Experimental Biology.

[6]  Joseph M. Muretta,et al.  Direct real-time detection of the structural and biochemical events in the myosin power stroke , 2015, Proceedings of the National Academy of Sciences.

[7]  D. Szczesna‐Cordary,et al.  Molecular mechanisms of cardiomyopathy phenotypes associated with myosin light chain mutations , 2015, Journal of Muscle Research and Cell Motility.

[8]  David D. Thomas,et al.  Amplitude of the actomyosin power stroke depends strongly on the isoform of the myosin essential light chain , 2015, Proceedings of the National Academy of Sciences.

[9]  J. Spudich.  The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy. , 2015, Biochemical Society transactions.

[10]  D. Szczesna‐Cordary,et al.  Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH2 terminus of the RLC on β-myosin cross-bridge mechanics. , 2014, Journal of applied physiology.

[11]  D. Szczesna‐Cordary,et al.  Remodeling of the heart in hypertrophy in animal models with myosin essential light chain mutations , 2014, Front. Physiol..

[12]  J. Spudich,et al.  Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases , 2014, Biophysical journal.

[13]  A. Pereira,et al.  Hypertrophic Cardiomyopathy: How do Mutations Lead to Disease? , 2014, Arquivos brasileiros de cardiologia.

[14]  Tory M. Schaaf,et al.  Discovery of Enzyme Modulators via High-Throughput Time-Resolved FRET in Living Cells , 2014, Journal of biomolecular screening.

[15]  L. Leinwand,et al.  The Hypertrophic Cardiomyopathy Myosin Mutation R453C Alters ATP Binding and Hydrolysis of Human Cardiac β-Myosin* , 2013, The Journal of Biological Chemistry.

[16]  D. Szczesna‐Cordary,et al.  Discrete effects of A57G-myosin essential light chain mutation associated with familial hypertrophic cardiomyopathy. , 2013, American journal of physiology. Heart and circulatory physiology.

[17]  Joseph M. Muretta,et al.  Direct real-time detection of the actin-activated power stroke within the myosin catalytic domain , 2013, Proceedings of the National Academy of Sciences.

[18]  Joseph M. Muretta,et al.  4.12 Spectroscopic Probes of Muscle Proteins , 2012 .

[19]  Joseph M. Muretta,et al.  Allosteric communication in Dictyostelium myosin II , 2012, Journal of Muscle Research and Cell Motility.

[20]  David D. Thomas,et al.  Structural and functional dynamics of an integral membrane protein complex modulated by lipid headgroup charge. , 2012, Journal of molecular biology.

[21]  C. Reggiani.  Faculty Opinions recommendation of Identification of functional differences between recombinant human α and β cardiac myosin motors. , 2012 .

[22]  T. Irving,et al.  Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  Alexander Kyrychenko,et al.  High-performance time-resolved fluorescence by direct waveform recording. , 2010, The Review of scientific instruments.

[24]  I. V. Negrashov,et al.  Structural dynamics of the myosin relay helix by time-resolved EPR and FRET , 2009, Proceedings of the National Academy of Sciences.

[25]  A. Perrot,et al.  Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance. , 2009, Biophysical journal.

[26]  David D. Thomas,et al.  Site-directed spectroscopic probes of actomyosin structural dynamics. , 2009, Annual review of biophysics.

[27]  David D. Thomas,et al.  Phosphorylation-induced structural changes in smooth muscle myosin regulatory light chain , 2009, Proceedings of the National Academy of Sciences.

[28]  M. Titus,et al.  Muscle and nonmuscle myosins probed by a spin label at equivalent sites in the force-generating domain , 2008, Proceedings of the National Academy of Sciences.

[29]  S. Lowey,et al.  Functional Effects of the Hypertrophic Cardiomyopathy R403Q Mutation Are Different in an α- or β-Myosin Heavy Chain Backbone* , 2008, Journal of Biological Chemistry.

[30]  R. Ramaraj,et al.  Hypertrophic Cardiomyopathy: Etiology, Diagnosis, and Treatment , 2008, Cardiology in review.

[31]  G. Wolff,et al.  Molecular modeling of the myosin-S1(A1) isoform. , 2007, Journal of structural biology.

[32]  G. Guzman,et al.  Myosin essential light chain in health and disease. , 2007, American journal of physiology. Heart and circulatory physiology.

[33]  S. Rosenfeld,et al.  A Model of Myosin V Processivity* , 2004, Journal of Biological Chemistry.

[34]  David D. Thomas,et al.  Structural dynamics of actin during active interaction with myosin: different effects of weakly and strongly bound myosin heads. , 2004, Biochemistry.

[35]  Christine E Seidman,et al.  Phenotypic diversity in hypertrophic cardiomyopathy. , 2002, Human molecular genetics.

[36]  H. Nishi,et al.  Different expressivity of a ventricular essential myosin light chain gene Ala57Gly mutation in familial hypertrophic cardiomyopathy. , 2001, American heart journal.

[37]  I. Morano.  Tuning the human heart molecular motors by myosin light chains , 1999, Journal of Molecular Medicine.

[38]  B. Hainque,et al.  Familial hypertrophic cardiomyopathy: from mutations to functional defects. , 1998, Circulation research.

[39]  D. Timson,et al.  The N-terminus of A1-type myosin essential light chains binds actin and modulates myosin motor function. , 1998, European journal of biochemistry.

[40]  D. D. Thomas,et al.  A large and distinct rotation of the myosin light chain domain occurs upon muscle contraction. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[41]  H. Haase,et al.  Different actin affinities of human cardiac essential myosin light chain isoforms , 1997, FEBS letters.

[42]  P. Lange,et al.  Regulation of human heart contractility by essential myosin light chain isoforms. , 1996, The Journal of clinical investigation.

[43]  R. Chisholm,et al.  Targeted disruption of the Dictyostelium myosin essential light chain gene produces cells defective in cytokinesis and morphogenesis. , 1995, Journal of cell science.

[44]  T. Timek,et al.  Myosin light chain-actin interaction regulates cardiac contractility. , 1995, Circulation research.

[45]  H. Sweeney.  Function of the N terminus of the myosin essential light chain of vertebrate striated muscle. , 1995, Biophysical journal.

[46]  K. Trybus,et al.  The essential light chain is required for full force production by skeletal muscle myosin. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[47]  K. Trybus.  Regulation of expressed truncated smooth muscle myosins. Role of the essential light chain and tail length. , 1994, The Journal of biological chemistry.

[48]  K. Trybus,et al.  Skeletal muscle myosin light chains are essential for physiological speeds of shortening , 1993, Nature.

[49]  D A Winkelmann,et al.  Three-dimensional structure of myosin subfragment-1: a molecular motor. , 1993, Science.

[50]  R A Milligan,et al.  Structure of the actin-myosin complex and its implications for muscle contraction. , 1993, Science.

[51]  J. Stull,et al.  Myosin light chain phosphorylation in vertebrate striated muscle: regulation and function. , 1993, The American journal of physiology.

[52]  M. Geeves.  Dynamic interaction between actin and myosin subfragment 1 in the presence of ADP. , 1989, Biochemistry.

[53]  S. J. Smith,et al.  Bovine cardiac myosin subfragment 1. Transient kinetics of ATP hydrolysis. , 1984, Journal of Biological Chemistry.

[54]  A. Weeds,et al.  The magnesium-ion-dependent adenosine triphosphatase of bovine cardiac Myosin and its subfragment-1. , 1976, The Biochemical journal.

[55]  G. Frank,et al.  The amino-acid sequence of the alkali light chains of rabbit skeletal-muscle myosin. , 1974, European journal of biochemistry.

[56]  S. Lowey,et al.  Light Chains from Fast and Slow Muscle Myosins , 1971, Nature.

[57]  Howard A. Rockman,et al.  Clinical Medicine , 1915, The Indian Medical Gazette.

[58]  E. M. De La Cruz,et al.  Kinetic and equilibrium analysis of the myosin ATPase. , 2009, Methods in enzymology.

[59]  A. Houdusse,et al.  Structure of the regulatory domain of scallop myosin at 2 A resolution: implications for regulation. , 1996, Structure.

[60]  D. W. Hayden,et al.  The mechanism of force generation in myosin: a disorder-to-order transition, coupled to internal structural changes. , 1995, Biophysical journal.

[61]  R. Bonow.  Left ventricular diastolic function in hypertrophic cardiomyopathy. , 1991, Herz.

[62]  J. Lakowicz.  Principles of fluorescence spectroscopy , 1983 .