Fate and transport of antibiotic residues and antibiotic resistance genes following land application of manure waste.

Antibiotics are used in animal livestock production for therapeutic treatment of disease and at subtherapeutic levels for growth promotion and improvement of feed efficiency. It is estimated that approximately 75% of antibiotics are not absorbed by animals and are excreted in waste. Antibiotic resistance selection occurs among gastrointestinal bacteria, which are also excreted in manure and stored in waste holding systems. Land application of animal waste is a common disposal method used in the United States and is a means for environmental entry of both antibiotics and genetic resistance determinants. Concerns for bacterial resistance gene selection and dissemination of resistance genes have prompted interest about the concentrations and biological activity of drug residues and break-down metabolites, and their fate and transport. Fecal bacteria can survive for weeks to months in the environment, depending on species and temperature, however, genetic elements can persist regardless of cell viability. Phylogenetic analyses indicate antibiotic resistance genes have evolved, although some genes have been maintained in bacteria before the modern antibiotic era. Quantitative measurements of drug residues and levels of resistance genes are needed, in addition to understanding the environmental mechanisms of genetic selection, gene acquisition, and the spatiotemporal dynamics of these resistance genes and their bacterial hosts. This review article discusses an accumulation of findings that address aspects of the fate, transport, and persistence of antibiotics and antibiotic resistance genes in natural environments, with emphasis on mechanisms pertaining to soil environments following land application of animal waste effluent.

[1]  Gregor Blaha,et al.  Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. , 2008, Journal of molecular biology.

[2]  J. Macdonald The Economic Organization of U.S. Broiler Production , 2008 .

[3]  Satish C. Gupta,et al.  Antibiotic losses from unprotected manure stockpiles. , 2008, Journal of environmental quality.

[4]  B. Faulkner,et al.  Fecal source tracking by antibiotic resistance analysis on a watershed exhibiting low resistance , 2008, Environmental monitoring and assessment.

[5]  P. Axelsen A chaotic pore model of polypeptide antibiotic action. , 2008, Biophysical journal.

[6]  P M Bennett,et al.  Plasmid encoded antibiotic resistance: acquisition and transfer of antibiotic resistance genes in bacteria , 2008, British journal of pharmacology.

[7]  E. Grohmann,et al.  Detection of conjugative plasmids and antibiotic resistance genes in anthropogenic soils from Germany and India. , 2008, FEMS microbiology letters.

[8]  Linsheng Song,et al.  Diverse Tetracycline Resistant Bacteria and Resistance Genes from Coastal Waters of Jiaozhou Bay , 2008, Microbial Ecology.

[9]  C. Harwood,et al.  Uncharted Microbial World: Microbes and Their Activities in the Environment , 2007 .

[10]  Kurt E. Williamson,et al.  Prevalence of Lysogeny among Soil Bacteria and Presence of 16S rRNA and trzN Genes in Viral-Community DNA , 2007, Applied and Environmental Microbiology.

[11]  Kurt E. Williamson,et al.  Incidence of lysogeny within temperate and extreme soil environments. , 2007, Environmental microbiology.

[12]  R. Lenski,et al.  The cost of antibiotic resistance--from the perspective of a bacterium. , 2007, Ciba Foundation symposium.

[13]  Youn-Kyoo Choung,et al.  Degradation of Antibiotics (Tetracycline, Sulfathiazole, Ampicillin) Using Enzymes of Glutathion S-Transferase , 2007 .

[14]  Satish C. Gupta,et al.  Sulfamethazine uptake by plants from manure-amended soil. , 2007, Journal of environmental quality.

[15]  W. Buchberger Novel analytical procedures for screening of drug residues in water, waste water, sediment and sludge. , 2007, Analytica chimica acta.

[16]  R. Mackie,et al.  Evolution and ecology of antibiotic resistance genes. , 2007, FEMS microbiology letters.

[17]  Y. Kawarabayasi,et al.  Crystal structure of an archaeal homologue of multidrug resistance repressor protein, EmrR, from hyperthermophilic archaea Sulfolobus tokodaii strain 7 , 2007, Proteins: Structure, Function, and Bioinformatics.

[18]  S. Koike,et al.  Monitoring and Source Tracking of Tetracycline Resistance Genes in Lagoons and Groundwater Adjacent to Swine Production Facilities over a 3-Year Period , 2007, Applied and Environmental Microbiology.

[19]  Diana S. Aga,et al.  Analysis of tetracycline antibiotics in soil : Advances in extraction, clean-up, and quantification , 2007 .

[20]  F. Michel,et al.  Development and Application of Real-Time PCR Assays for Quantification of erm Genes Conferring Resistance to Macrolides-Lincosamides-Streptogramin B in Livestock Manure and Manure Management Systems , 2007, Applied and Environmental Microbiology.

[21]  T. Stanton Prophage-like gene transfer agents-novel mechanisms of gene exchange for Methanococcus, Desulfovibrio, Brachyspira, and Rhodobacter species. , 2007, Anaerobe.

[22]  F. Curriero,et al.  Antibiotic-Resistant Enterococci and Fecal Indicators in Surface Water and Groundwater Impacted by a Concentrated Swine Feeding Operation , 2007, Environmental health perspectives.

[23]  A. Nocker,et al.  Genotypic Microbial Community Profiling: A Critical Technical Review , 2007, Microbial Ecology.

[24]  Michael Wagner,et al.  Unravelling Microbial Communities with DNA-Microarrays: Challenges and Future Directions , 2007, Microbial Ecology.

[25]  H. Heuer,et al.  Manure and sulfadiazine synergistically increased bacterial antibiotic resistance in soil over at least two months. , 2007, Environmental microbiology.

[26]  K. Kümmerer,et al.  Ultimate biodegradation and elimination of antibiotics in inherent tests. , 2007, Chemosphere.

[27]  K. Scott,et al.  Distribution of specific tetracycline and erythromycin resistance genes in environmental samples assessed by macroarray detection. , 2007, Environmental microbiology.

[28]  P. Thorne,et al.  The Potential Role of Concentrated Animal Feeding Operations in Infectious Disease Epidemics and Antibiotic Resistance , 2006, Environmental health perspectives.

[29]  A. Boxall,et al.  A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. , 2006, Chemosphere.

[30]  F. Larney,et al.  Fresh, stockpiled, and composted beef cattle feedlot manure: nutrient levels and mass balance estimates in Alberta and Manitoba. , 2006, Journal of environmental quality.

[31]  T. Urich,et al.  Archaea predominate among ammonia-oxidizing prokaryotes in soils , 2006, Nature.

[32]  H. Flint,et al.  Comparative Analysis of Sequences Flanking tet(W) Resistance Genes in Multiple Species of Gut Bacteria , 2006, Antimicrobial Agents and Chemotherapy.

[33]  S. Allaire,et al.  Sorption kinetics of chlortetracyline and tylosin on sandy loam and heavy clay soils. , 2006, Journal of environmental quality.

[34]  Y. Agersø,et al.  Genes homologous to glycopeptide resistance vanA are widespread in soil microbial communities. , 2006, FEMS microbiology letters.

[35]  Q. Huang,et al.  Interactions of DNA with clay minerals and soil colloidal particles and protection against degradation by DNase. , 2006, Environmental science & technology.

[36]  D. Massé,et al.  Reduction of indicator and pathogenic microorganisms by psychrophilic anaerobic digestion in swine slurries. , 2006, Bioresource technology.

[37]  J. Dolfing,et al.  Exocellular electron transfer in anaerobic microbial communities. , 2006, Environmental microbiology.

[38]  H. Chen,et al.  Adsorption of DNA on clay minerals and various colloidal particles from an Alfisol , 2006 .

[39]  A. Boxall,et al.  Uptake of veterinary medicines from soils into plants. , 2006, Journal of agricultural and food chemistry.

[40]  M. McClelland,et al.  DNA microarray detection of antimicrobial resistance genes in diverse bacteria. , 2006, International journal of antimicrobial agents.

[41]  D. Hughes,et al.  Sampling the Antibiotic Resistome , 2006, Science.

[42]  K. Portier,et al.  Geographical variation in antibiotic resistance profiles of Escherichia coli isolated from swine, poultry, beef and dairy cattle farm water retention ponds in Florida 1 , 2006, Journal of applied microbiology.

[43]  T. Callaway,et al.  Evolution of foodborne pathogens via temperate bacteriophage-mediated gene transfer. , 2005, Foodborne pathogens and disease.

[44]  Christopher S Ward,et al.  Effects of sublethal UVA irradiation on activity levels of oxidative defense enzymes and protein oxidation in Escherichia coli. , 2005, Journal of photochemistry and photobiology. B, Biology.

[45]  C. Rosen,et al.  Antibiotic uptake by plants from soil fertilized with animal manure. , 2005, Journal of environmental quality.

[46]  Zhongtang Yu,et al.  Development and Application of Real-Time PCR Assays for Quantification of Genes Encoding Tetracycline Resistance , 2005, Applied and Environmental Microbiology.

[47]  Heike Schmitt,et al.  Effects of antibiotics on soil microorganisms: time and nutrients influence pollution-induced community tolerance , 2005 .

[48]  P M Bennett,et al.  Assessment of the fitness impacts on Escherichia coli of acquisition of antibiotic resistance genes encoded by different types of genetic element. , 2005, The Journal of antimicrobial chemotherapy.

[49]  H. Heuer,et al.  PCR Detection of Oxytetracycline Resistance Genes otr(A) and otr(B) in Tetracycline-Resistant Streptomycete Isolates from Diverse Habitats , 2005, Current Microbiology.

[50]  Johannes Lehmann,et al.  Long-term dynamics of phosphorus forms and retention in manure-amended soils. , 2005, Environmental science & technology.

[51]  L. Alban,et al.  Survival of Escherichia coli and Salmonella Typhimurium in slurry applied to clay soil on a Danish swine farm. , 2005, Preventive veterinary medicine.

[52]  T. Moorman,et al.  Sorption of tylosin onto swine manure. , 2005, Chemosphere.

[53]  C. Stamm,et al.  Surface runoff and transport of sulfonamide antibiotics and tracers on manured grassland. , 2005, Journal of environmental quality.

[54]  É. Hegedűs,et al.  Survivability of vancomycin resistant enterococci and fitness cost of vancomycin resistance acquisition , 2005, Journal of Clinical Pathology.

[55]  Kurt E. Williamson,et al.  Abundance and Diversity of Viruses in Six Delaware Soils , 2005, Applied and Environmental Microbiology.

[56]  W. Graninger,et al.  DNA in Antibiotic Preparations: Absence of Intact Resistance Genes , 2005, Antimicrobial Agents and Chemotherapy.

[57]  A. Boxall,et al.  Transport of veterinary antibiotics in overland flow following the application of slurry to arable land. , 2005, Chemosphere.

[58]  F. Haesebrouck,et al.  Molecular Analysis of Human, Porcine, and Poultry Enterococcus faecium Isolates and Their erm(B) Genes , 2005, Applied and Environmental Microbiology.

[59]  H. Nau,et al.  Different behavior of tetracyclines and sulfonamides in sandy soils after repeated fertilization with liquid manure , 2005, Environmental toxicology and chemistry.

[60]  J. Kaneene,et al.  Patterns of Antimicrobial Resistance Observed in Escherichia coli Isolates Obtained from Domestic- and Wild-Animal Fecal Samples, Human Septage, and Surface Water , 2005, Applied and Environmental Microbiology.

[61]  H. Flint,et al.  Hybrid tet Genes and tet Gene Nomenclature: Request for Opinion , 2005, Antimicrobial Agents and Chemotherapy.

[62]  O. Sahin,et al.  Enhanced in vivo fitness of fluoroquinolone-resistant Campylobacter jejuni in the absence of antibiotic selection pressure. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[63]  Charles W. Knapp,et al.  Quantification of Tetracycline Resistance Genes in Feedlot Lagoons by Real-Time PCR , 2004, Applied and Environmental Microbiology.

[64]  R. Andrews,et al.  Survival of enterococci and Tn916-like conjugative transposons in soil. , 2004, Canadian journal of microbiology.

[65]  Klaus Kümmerer,et al.  Assessment of degradation of 18 antibiotics in the Closed Bottle Test. , 2004, Chemosphere.

[66]  Johanne Beausse,et al.  Selected drugs in solid matrices: a review of environmental determination, occurrence and properties of principal substances , 2004 .

[67]  T. Vogel,et al.  Isolation of Lightning-Competent Soil Bacteria , 2004, Applied and Environmental Microbiology.

[68]  B. Pearson,et al.  Nucleotide sequences and comparison of two large conjugative plasmids from different Campylobacter species. , 2004, Microbiology.

[69]  M. Hutchison,et al.  Effect of Length of Time before Incorporation on Survival of Pathogenic Bacteria Present in Livestock Wastes Applied to Agricultural Soil , 2004, Applied and Environmental Microbiology.

[70]  Wolf-Dietrich Hardt,et al.  Phages and the Evolution of Bacterial Pathogens: from Genomic Rearrangements to Lysogenic Conversion , 2004, Microbiology and Molecular Biology Reviews.

[71]  Yanping Wang,et al.  Human intestinal bacteria as reservoirs for antibiotic resistance genes. , 2004, Trends in microbiology.

[72]  J. Handelsman,et al.  Uncultured soil bacteria are a reservoir of new antibiotic resistance genes. , 2004, Environmental microbiology.

[73]  S. Rosenberg,et al.  Antibiotic-induced lateral transfer of antibiotic resistance. , 2004, Trends in microbiology.

[74]  P. Woo,et al.  Lack of Evidence that DNA in Antibiotic Preparations Is a Source of Antibiotic Resistance Genes in Bacteria from Animal or Human Sources , 2004, Antimicrobial Agents and Chemotherapy.

[75]  K. Kümmerer Resistance in the environment. , 2004, The Journal of antimicrobial chemotherapy.

[76]  A. De Visscher,et al.  Nitrogen cycling through swine production systems: ammonia, dinitrogen, and nitrous oxide emissions. , 2004, Journal of environmental quality.

[77]  M. Rasmussen,et al.  Diverse Tetracycline Resistance Genotypes of Megasphaera elsdenii Strains Selectively Cultured from Swine Feces , 2004, Applied and Environmental Microbiology.

[78]  D. Livermore,et al.  Enhancement of host fitness by the sul2-coding plasmid p9123 in the absence of selective pressure. , 2004, The Journal of antimicrobial chemotherapy.

[79]  Alistair B A Boxall,et al.  Fate of veterinary antibiotics in a macroporous tile drained clay soil , 2004, Environmental toxicology and chemistry.

[80]  C. Cerniglia,et al.  Mineralization of erythromycin A in aquaculture sediments. , 2004, FEMS microbiology letters.

[81]  S. R. Clark,et al.  Inhibition of Resistance Plasmid Transfer in Escherichia coli by Ionophores, Chlortetracycline, Bacitracin, and Ionophore/Antimicrobial Combinations , 2004, Avian diseases.

[82]  D. Dubnau,et al.  DNA uptake during bacterial transformation , 2004, Nature Reviews Microbiology.

[83]  Andreas Kappler,et al.  Phenazines and Other Redox-Active Antibiotics Promote Microbial Mineral Reduction , 2004, Applied and Environmental Microbiology.

[84]  T. R. Licht,et al.  Effect of Tetracycline on Transfer and Establishment of the Tetracycline-Inducible Conjugative Transposon Tn916 in the Guts of Gnotobiotic Rats , 2004, Applied and Environmental Microbiology.

[85]  M. Weinbauer,et al.  Are viruses driving microbial diversification and diversity? , 2003, Environmental microbiology.

[86]  W. H. Wilson,et al.  Encapsidation of host DNA by bacteriophages infecting marine Synechococcus strains. , 2003, FEMS microbiology ecology.

[87]  K. Carlson,et al.  Evolution of antibiotic occurrence in a river through pristine, urban and agricultural landscapes. , 2003, Water research.

[88]  L. Ming Structure and function of “metalloantibiotics” , 2003, Medicinal research reviews.

[89]  D. Volokhov,et al.  Microarray analysis of erythromycin resistance determinants , 2003, Journal of applied microbiology.

[90]  D. Call,et al.  Identifying Antimicrobial Resistance Genes with DNA Microarrays , 2003, Antimicrobial Agents and Chemotherapy.

[91]  M. Goss,et al.  Movement of Faecal Bacteria through the Vadose Zone , 2003 .

[92]  M. Cotta,et al.  Isolation, characterization and comparison of bacteria from swine faeces and manure storage pits. , 2003, Environmental microbiology.

[93]  S. Bhattacharjee,et al.  Colloid transport in a geochemically heterogeneous porous medium: aquifer tank experiment and modeling. , 2003, Journal of contaminant hydrology.

[94]  L. Halverson,et al.  Rainfall timing and frequency influence on leaching of Escherichia coli RS2G through soil following manure application. , 2003, Journal of environmental quality.

[95]  J. Hacker,et al.  Impact of antibiotics on conjugational resistance gene transfer in Staphylococcus aureus in sewage. , 2003, Environmental microbiology.

[96]  T. Stanton,et al.  Isolation of Tetracycline-Resistant Megasphaera elsdenii Strains with Novel Mosaic Gene Combinations of tet(O) and tet(W) from Swine , 2003, Applied and Environmental Microbiology.

[97]  T. LaPara,et al.  Tylosin-resistant bacteria cultivated from agricultural soil. , 2003, FEMS microbiology letters.

[98]  T. Y. Guan,et al.  Pathogen survival in swine manure environments and transmission of human enteric illness--a review. , 2003, Journal of environmental quality.

[99]  S. Connell,et al.  Mechanism of Tet(O)‐mediated tetracycline resistance , 2003, The EMBO journal.

[100]  J. Fry,et al.  Elevated Abundance of Bacteriophage Infecting Bacteria in Soil , 2003, Applied and Environmental Microbiology.

[101]  J. M. Simpson,et al.  Microbial source tracking: state of the science. , 2002, Environmental science & technology.

[102]  H. Heuer,et al.  Gentamicin resistance genes in environmental bacteria: prevalence and transfer. , 2002, FEMS microbiology ecology.

[103]  Kathleen A. Smith,et al.  Antimicrobial residues in animal waste and water resources proximal to large-scale swine and poultry feeding operations. , 2002, The Science of the total environment.

[104]  P. Ndegwa,et al.  Influence of Anaerobic Pre-conditioning on Phosphorus Removal in Swine Manure by Aeration , 2002 .

[105]  H. Sørum,et al.  Antibiotic resistance in food-related bacteria--a result of interfering with the global web of bacterial genetics. , 2002, International journal of food microbiology.

[106]  U. Stelzl,et al.  The tetracycline resistance protein Tet(○) perturbs the conformation of the ribosomal decoding centre , 2002, Molecular microbiology.

[107]  A. Salyers,et al.  Characterization of Genes Involved in Modulation of Conjugal Transfer of the Bacteroides Conjugative Transposon CTnDOT , 2002, Journal of bacteriology.

[108]  M. Morgan,et al.  Antibiotic Resistance of Gram-Negative Bacteria in Rivers, United States , 2002, Emerging infectious diseases.

[109]  B. Halling‐Sørensen,et al.  Determination of the distribution coefficient (log Kd) of oxytetracycline, tylosin A, olaquindox and metronidazole in manure. , 2002, Chemosphere.

[110]  Nwadiuto Esiobu,et al.  Antibiotic resistance in soil and water environments , 2002, International journal of environmental health research.

[111]  A. Boxall,et al.  The sorption and transport of a sulphonamide antibiotic in soil systems. , 2002, Toxicology letters.

[112]  M. Doyle,et al.  Fate of Escherichia coli O157:H7 in Manure-Amended Soil , 2002, Applied and Environmental Microbiology.

[113]  B. White,et al.  Development, Validation, and Application of PCR Primers for Detection of Tetracycline Efflux Genes of Gram-Negative Bacteria , 2002, Applied and Environmental Microbiology.

[114]  D. Newman,et al.  Protective Role of tolC in Efflux of the Electron Shuttle Anthraquinone-2,6-Disulfonate , 2002, Journal of bacteriology.

[115]  E. Thurman,et al.  Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. , 2002, Environmental science & technology.

[116]  H. Nau,et al.  Determination of persistent tetracycline residues in soil fertilized with liquid manure by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. , 2002, Analytical chemistry.

[117]  R. Brackett,et al.  Survival of Salmonella on tomatoes stored at high relative humidity, in soil, and on tomatoes in contact with soil. , 2002, Journal of food protection.

[118]  Kornelia Smalla,et al.  Occurrence and reservoirs of antibiotic resistance genes in the environment , 2002 .

[119]  R. V. Miller,et al.  RecA Expression in Response to Solar UVR in the Marine Bacterium Vibrio natriegens , 2001, Microbial Ecology.

[120]  D. Newman,et al.  Extracellular electron transfer , 2001, Cellular and Molecular Life Sciences CMLS.

[121]  M. Kivisaar,et al.  Involvement of ςS in Starvation-Induced Transposition of Pseudomonas putidaTransposon Tn4652 , 2001, Journal of bacteriology.

[122]  J Tolls,et al.  Sorption of veterinary pharmaceuticals in soils: a review. , 2001, Environmental science & technology.

[123]  T. Vogel,et al.  Laboratory-Scale Evidence for Lightning-Mediated Gene Transfer in Soil , 2001, Applied and Environmental Microbiology.

[124]  Robertv . Miller Environmental bacteriophage-host interactions: factors contribution to natural transduction , 2001, Antonie van Leeuwenhoek.

[125]  P. Simonet,et al.  Natural Transformation of Pseudomonas fluorescens and Agrobacterium tumefaciens in Soil , 2001, Applied and Environmental Microbiology.

[126]  H. Sørum,et al.  Resistance to antibiotics in the normal flora of animals. , 2001, Veterinary research.

[127]  R. Mackie,et al.  Occurrence and Diversity of Tetracycline Resistance Genes in Lagoons and Groundwater Underlying Two Swine Production Facilities , 2001, Applied and Environmental Microbiology.

[128]  B. Halling‐Sørensen,et al.  Biodegradability of metronidazole, olaquindox, and tylosin and formation of tylosin degradation products in aerobic soil--manure slurries. , 2001, Ecotoxicology and environmental safety.

[129]  K. Nielsen,et al.  Stimulatory effects of compounds present in the rhizosphere on natural transformation of Acinetobacter sp. BD413 in soil , 2001 .

[130]  H. Vlamakis,et al.  Evidence for Extensive Resistance Gene Transfer amongBacteroides spp. and among Bacteroides and Other Genera in the Human Colon , 2001, Applied and Environmental Microbiology.

[131]  R. Mackie,et al.  Molecular Ecology of Tetracycline Resistance: Development and Validation of Primers for Detection of Tetracycline Resistance Genes Encoding Ribosomal Protection Proteins , 2001, Applied and Environmental Microbiology.

[132]  P. Simonet,et al.  Evaluation of Biological and Physical Protection against Nuclease Degradation of Clay-Bound Plasmid DNA , 2001, Applied and Environmental Microbiology.

[133]  Gary L. Cromwell,et al.  18 Antimicrobial and Promicrobial Agents , 2000 .

[134]  M. Stoskopf,et al.  The Kinetics of Oxytetracycline Degradation in Deionized Water under Varying Temperature, pH, Light, Substrate, and Organic Matter , 2000 .

[135]  Ola Sköld,et al.  Sulfonamide resistance: mechanisms and trends. , 2000, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

[136]  J. S. Santo Domingo,et al.  Survival of Salmonella Species in River Water , 2000, Current Microbiology.

[137]  R. Andrews,et al.  Isolation of Tn916-like conjugal elements from swine lot effluent. , 2000, Canadian journal of microbiology.

[138]  G. Stotzky Persistence and Biological Activity in Soil of Insecticidal Proteins from Bacillus thuringiensis and of Bacterial DNA Bound on Clays and Humic Acids , 2000 .

[139]  N. H. Spliid,et al.  Sorption and mobility of metronidazole, olaquindox, oxytetracycline and tylosin in soil. , 2000, Chemosphere.

[140]  K Kümmerer,et al.  Biodegradability of some antibiotics, elimination of the genotoxicity and affection of wastewater bacteria in a simple test. , 2000, Chemosphere.

[141]  K. Wommack,et al.  Virioplankton: Viruses in Aquatic Ecosystems , 2000, Microbiology and Molecular Biology Reviews.

[142]  R. Schwarzenbach,et al.  Photolytic Transformation of Organic Pollutants on Soil SurfacesAn Experimental Approach , 2000 .

[143]  K. Nielsen,et al.  Natural Transformation of Acinetobactersp. Strain BD413 with Cell Lysates of Acinetobacter sp.,Pseudomonas fluorescens, and Burkholderia cepaciain Soil Microcosms , 2000, Applied and Environmental Microbiology.

[144]  S. Hassanizadeh,et al.  Removal of Viruses by Soil Passage: Overview of Modeling, Processes, and Parameters , 2000 .

[145]  G. Stotzky,et al.  Transformation and survival of donor, recipient, and transformants of Bacillus subtilis in vitro and in soil , 1999 .

[146]  Malcolm Bennett,et al.  Enterobacteria: Antibiotic resistance found in wild rodents , 1999, Nature.

[147]  R. Hall,et al.  Transposon Tn21, Flagship of the Floating Genome , 1999, Microbiology and Molecular Biology Reviews.

[148]  R. A. Conway,et al.  Use of Antibiotic Resistance Analysis To Identify Nonpoint Sources of Fecal Pollution , 1999, Applied and Environmental Microbiology.

[149]  Stefan Wuertz,et al.  High Rates of Conjugation in Bacterial Biofilms as Determined by Quantitative In Situ Analysis , 1999, Applied and Environmental Microbiology.

[150]  Samuel D. Oman,et al.  Quantitative assessment of the inactivation of pathogenic and indicator viruses in natural water sources , 1999 .

[151]  K. Smalla,et al.  Monitoring field releases of genetically modified sugar beets for persistence of transgenic plant DNA and horizontal gene transfer , 1999 .

[152]  D. Bolton,et al.  The‐survival‐characteristics‐of‐a‐non‐toxigenic‐strain‐of‐Escherichia‐coli‐O157:H7 , 1999, Journal of applied microbiology.

[153]  J. Trevors Evolution of gene transfer in bacteria , 1999 .

[154]  H. Flint,et al.  Evidence for recent intergeneric transfer of a new tetracycline resistance gene, tet(W), isolated from Butyrivibrio fibrisolvens, and the occurrence of tet(O) in ruminal bacteria. , 1999, Environmental microbiology.

[155]  R Hirsch,et al.  Occurrence of antibiotics in the aquatic environment. , 1999, The Science of the total environment.

[156]  G. Khachatourians,et al.  Agricultural use of antibiotics and the evolution and transfer of antibiotic-resistant bacteria. , 1998, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[157]  J. Grove,et al.  Fecal Bacteria Survival and Infiltration through a Shallow Agricultural Soil: Timing and Tillage Effects , 1998 .

[158]  G. Stotzky,et al.  Binding of DNA on humic acids: Effect on transformation of Bacillus subtilis and resistance to DNase , 1998 .

[159]  Sunny C. Jiang,et al.  Gene Transfer by Transduction in the Marine Environment , 1998, Applied and Environmental Microbiology.

[160]  M. Doyle,et al.  Survival of enterohemorrhagic Escherichia coli O157:H7 in water. , 1998, Journal of food protection.

[161]  J. V. van Elsas,et al.  Isolation, Characterization, and Transfer of Cryptic Gene-Mobilizing Plasmids in the Wheat Rhizosphere , 1998, Applied and Environmental Microbiology.

[162]  P. Marsh,et al.  Extended Survival and Persistence of Campylobacterspp. in Water and Aquatic Biofilms and Their Detection by Immunofluorescent-Antibody and -rRNA Staining , 1998, Applied and Environmental Microbiology.

[163]  M. Roberts,et al.  Antibiotic resistance mechanisms in bacteria of oral and upper respiratory origin. , 1998, International journal of antimicrobial agents.

[164]  R. E. Bowen,et al.  Antibiotic use in animal agriculture , 1997, Journal of applied microbiology.

[165]  A. Salyers,et al.  Why are antibiotic resistance genes so resistant to elimination? , 1997, Antimicrobial agents and chemotherapy.

[166]  M. G. Lorenz,et al.  Mechanism of Retarded DNA Degradation and Prokaryotic Origin of DNases in Nonsterile Soils , 1997 .

[167]  R. Tauxe,et al.  Emerging foodborne diseases: an evolving public health challenge. , 1997, Emerging infectious diseases.

[168]  S. Ricke,et al.  Antibiotic resistance profiles of Escherichia coli isolated from rural and urban environments , 1997 .

[169]  K. Smalla,et al.  Manure Enhances Plasmid Mobilization and Survival of Pseudomonas putida Introduced into Field Soil , 1997, Applied and environmental microbiology.

[170]  P. Vannuffel,et al.  Inhibition of protein synthesis by streptogramins and related antibiotics. , 1997, The Journal of antimicrobial chemotherapy.

[171]  M. Bailey,et al.  The acquisition of indigenous plasmids by a genetically marked pseudomonad population colonizing the sugar beet phytosphere is related to local environmental conditions , 1997, Applied and environmental microbiology.

[172]  C. Gerba,et al.  Fracture Aperture Measurements and Migration of Solutes, Viruses, and Immiscible Creosote in a Column of Clay‐Rich Till , 1996 .

[173]  W. Schlimme,et al.  Genetic transformation in freshwater: Escherichia coli is able to develop natural competence , 1996, Applied and environmental microbiology.

[174]  I. Pepper,et al.  Gene transfer of Alcaligenes eutrophus JMP134 plasmid pJP4 to indigenous soil recipients , 1996, Applied and environmental microbiology.

[175]  C. Cerniglia,et al.  PCR detection and quantitation of predominant anaerobic bacteria in human and animal fecal samples , 1996, Applied and environmental microbiology.

[176]  E. C. Berry,et al.  Influence of earthworm activity on gene transfer from Pseudomonas fluorescens to indigenous soil bacteria , 1996, Applied and environmental microbiology.

[177]  A. Stevens,et al.  Conjugative transposons: an unusual and diverse set of integrated gene transfer elements. , 1995, Microbiological reviews.

[178]  P Huovinen,et al.  Antimicrobial and mercury resistance in aerobic gram-negative bacilli in fecal flora among persons with and without dental amalgam fillings , 1995, Antimicrobial agents and chemotherapy.

[179]  Marylynn V. Yates,et al.  On the use of virus transport modeling for determining regulatory compliance , 1995 .

[180]  B. Macler Developing A National Drinking Water Regulation for Disinfection of Ground Water , 1995 .

[181]  Michael E. Essington,et al.  Surface application of liquid swine manure: Chemical variability , 1995 .

[182]  E. Roets,et al.  Study of the stability of tylosin A in aqueous solutions. , 1995, Journal of pharmaceutical and biomedical analysis.

[183]  H. Karch,et al.  Amplification methods in diagnostic bacteriology (selected examples) , 1995 .

[184]  Mark S. Coyne,et al.  Fecal bacteria in agricultural waters of the bluegrass region of Kentucky , 1995 .

[185]  H. Schmieger,et al.  Frequency of generalized transducing phages in natural isolates of the Salmonella typhimurium complex , 1995, Applied and environmental microbiology.

[186]  L. Garber,et al.  Prevalence of enterohemorrhagic Escherichia coli O157:H7 in a survey of dairy herds , 1995, Applied and environmental microbiology.

[187]  A. Grossman,et al.  Convergent sensing pathways mediate response to two extracellular competence factors in Bacillus subtilis. , 1995, Genes & development.

[188]  R. Fani,et al.  Transformation of Bacillus subtilis by DNA bound on clay in non-sterile soil. , 1994 .

[189]  B. Lunestad,et al.  Stability of antibacterial agents in an artificial marine aquaculture sediment studied under laboratory conditions , 1994 .

[190]  Charles P. Gerba,et al.  Microbial pollutants: their survival and transport pattern to groundwater. , 1994 .

[191]  M. G. Lorenz,et al.  Bacterial gene transfer by natural genetic transformation in the environment. , 1994, Microbiological reviews.

[192]  J. Gavalchin,et al.  The Persistence of Fecal-Borne Antibiotics in Soil , 1994 .

[193]  C. Gerba,et al.  Groundwater Pollution Microbiology , 1994 .

[194]  R. Gillham,et al.  Field Experiments in a Fractured Clay Till 2. Solute and Colloid Transport , 1993 .

[195]  P. Normand,et al.  Kinetics of the persistence of chromosomal DNA from genetically engineered Escherichia coli introduced into soil , 1993, Applied and environmental microbiology.

[196]  J. Davies,et al.  Antibiotic preparations contain DNA: a source of drug resistance genes? , 1993, Antimicrobial Agents and Chemotherapy.

[197]  A. Stevens,et al.  Tetracycline regulation of genes on Bacteroides conjugative transposons , 1993, Journal of bacteriology.

[198]  K L Josephson,et al.  Polymerase chain reaction detection of nonviable bacterial pathogens , 1993, Applied and environmental microbiology.

[199]  M. G. Lorenz,et al.  Use of polymerase chain reaction and electroporation of Escherichia coli to monitor the persistence of extracellular plasmid DNA introduced into natural soils , 1993, Applied and environmental microbiology.

[200]  Paul J. Cieslak,et al.  Escherichia coli 0157:H7 infection from a manured garden , 1993, The Lancet.

[201]  R. Gillham,et al.  Field experiments in a fractured clay till: 1. Hydraulic conductivity and fracture aperture , 1993 .

[202]  E. Balbinder,et al.  Effect of mutations in SOS genes on UV-induced precise excision of Tn10 in Escherichia coli. , 1993, Mutation research.

[203]  A. Nasser,et al.  Comparative Survival of E. Coli, F+Bacteriophages, HAV and Poliovirus 1 in Wastewater and Groundwater , 1993 .

[204]  R. Andrews,et al.  Tetracycline enhances Tn916-mediated conjugal transfer. , 1992, Plasmid.

[205]  P. Simonet,et al.  Adsorption of DNA on clay minerals: protection against DNaseI and influence on gene transfer , 1992 .

[206]  M. Chicurel,et al.  Bacterial plasmids and gene flux , 1992, Cell.

[207]  N. Cresswell,et al.  Gene transfer between streptomycetes in soil. , 1992, Gene.

[208]  R. V. Miller,et al.  Application of DNA probes to analysis of bacteriophage distribution patterns in the environment , 1992, Applied and environmental microbiology.

[209]  M. Khanna,et al.  Transformation of Bacillus subtilis by DNA bound on montmorillonite and effect of DNase on the transforming ability of bound DNA , 1992, Applied and environmental microbiology.

[210]  H. Sandermann,et al.  Plant metabolism of xenobiotics. , 1992, Trends in biochemical sciences.

[211]  M. Karapınar,et al.  Survival of Yersinia enterocolitica and Escherichia coli in spring water. , 1991, International journal of food microbiology.

[212]  G. Dunny,et al.  The conjugative transposon Tn925: enhancement of conjugal transfer by tetracycline in Enterococcus faecalis and mobilization of chromosomal genes in Bacillus subtilis and E. faecalis , 1991, Molecular and General Genetics MGG.

[213]  P. Trieu-Cuot,et al.  Inducible transfer of conjugative transposon Tn1545 from Enterococcus faecalis to Listeria monocytogenes in the digestive tracts of gnotobiotic mice , 1991, Antimicrobial Agents and Chemotherapy.

[214]  J. L. Burgess,et al.  Antibiotic resistance indexing of Escherichia coli to identify sources of fecal contamination in water. , 1990, Canadian journal of microbiology.

[215]  G. Sayler,et al.  DNA adsorption to soils and sediments. , 1988, Environmental science & technology.

[216]  W. Chao,et al.  Survival of Yersinia enterocolitica in the environment. , 1988, Canadian journal of microbiology.

[217]  L. Berglind,et al.  Persistence of oxytetracycline in sediments from fish farms , 1988 .

[218]  A. Salyers,et al.  Mobilization of Bacteroides plasmids by Bacteroides conjugal elements , 1988, Journal of bacteriology.

[219]  M. G. Lorenz,et al.  Adsorption of DNA to sand and variable degradation rates of adsorbed DNA , 1987, Applied and environmental microbiology.

[220]  R. Guy,et al.  Models for tetracycline in aquatic environments , 1987 .

[221]  R. Guy,et al.  Models for tetracycline in aquatic environments , 1987 .

[222]  R. Colwell,et al.  Viable but nonculturable stage of Campylobacter jejuni and its role in survival in the natural aquatic environment , 1986, Applied and environmental microbiology.

[223]  M. Millar,et al.  Beta-lactam antibiotics increase the frequency of plasmid transfer in Staphylococcus aureus. , 1986, The Journal of antimicrobial chemotherapy.

[224]  E. H. Marth,et al.  Microbial Survival in the Environment: Bacteria and Rickettsiae Important in Human and Animal Health , 1984 .

[225]  N. Ishiguro,et al.  Antibiotic-resistant coliforms in the waste of piggeries and dairy farms. , 1984, Nihon juigaku zasshi. The Japanese journal of veterinary science.

[226]  A. Donoho Biochemical studies on the fate of monensin in animals and in the environment. , 1984, Journal of animal science.

[227]  S. Goyal Indicators of Viruses , 1983 .

[228]  J. Craven,et al.  Persistence and distribution of pollution indicator bacteria on land used for disposal of piggery effluent , 1981, Applied and environmental microbiology.

[229]  M. Blaser,et al.  Survival of Campylobacter fetus subsp. jejuni in biological milieus , 1980, Journal of clinical microbiology.

[230]  L. Zibilske,et al.  Effect of Environmental Factors on Survival of Salmonella typhimurium in Soil 1 , 1978 .

[231]  J. Timoney,et al.  Heavy-Metal and Antibiotic Resistance in the Bacterial Flora of Sediments of New York Bight , 1978, Applied and environmental microbiology.

[232]  E. McCoy,et al.  Use of fecal streptococci as indicators of pollution in soil , 1978, Applied and environmental microbiology.

[233]  F. M. Wellings,et al.  Demonstration of Virus in Groundwater after Effluent Discharge onto Soil , 1975, Applied microbiology.

[234]  J Davies,et al.  Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[235]  G. K. Elmund,et al.  Role of excreted chlortetracycline in modifying the decomposition process in feedlot waste , 1971, Bulletin of environmental contamination and toxicology.

[236]  J. Hou,et al.  Kinetics and mechanism of degradation of ampicillin in solution. , 1969, Journal of pharmaceutical sciences.

[237]  David H. Smith R Factors Mediate Resistance to Mercury, Nickel, and Cobalt , 1967, Science.

[238]  F. Allison,et al.  ANTIBIOTICS IN SOILS: 4. POLYPEPTIDES AND MACROLIDES , 1962 .

[239]  F. Allison,et al.  ANTIBIOTICS IN SOILS: II. EXTENT AND MECHANISM OF RELEASE , 1961 .

[240]  F. Allison,et al.  ANTIBIOTICS IN SOILS: 1. PHYSICO‐CHEMICAL STUDIES OF ANTIBIOTIC‐CLAY COMPLEXES , 1961 .

[241]  K. Kümmerer,et al.  Anaerobic inhibition and biodegradation of antibiotics in ISO test schemes. , 2007, Chemosphere.

[242]  E. Alocilja,et al.  PATHOGENS IN ANIMAL WASTES AND THE IMPACTS OF WASTE MANAGEMENT PRACTICES ON THEIR SURVIVAL, TRANSPORT AND FATE , 2006 .

[243]  T. Moorman,et al.  Degradation and Metabolite Production of Tylosin in Anaerobic and Aerobic Swine‐Manure Lagoons , 2005, Water environment research : a research publication of the Water Environment Federation.

[244]  D. Bradley,et al.  Structure and Function of , 2005 .

[245]  A. Boxall,et al.  Veterinary medicines in the environment. , 2004, Reviews of environmental contamination and toxicology.

[246]  John W. Beaber,et al.  SOS response promotes horizontal dissemination of antibiotic resistance genes , 2004, Nature.

[247]  C. Rotz Management to reduce nitrogen losses in animal production. , 2004, Journal of animal science.

[248]  C. Daughton PPCPs in the Environment: Future Research — Beginning with the End Always in Mind , 2004 .

[249]  B. Faulkner,et al.  Movement and Longevity of Viruses in the Subsurface , 2003 .

[250]  D. Lerner,et al.  Microbial contamination of two urban sandstone aquifers in the UK. , 2003, Water research.

[251]  Bent Halling-Sørensen,et al.  Bacterial antibiotic resistance levels in Danish farmland as a result of treatment with pig manure slurry. , 2003, Environment international.

[252]  Ching-Hua Huang,et al.  Assessment of Potential Antibiotic Contaminants in Water and Preliminary Occurrence Analysis , 2001 .

[253]  C. Fulhage,et al.  Swine Manure Management Systems in Missouri , 2001 .

[254]  K. Kümmerer Pharmaceuticals in the Environment , 2001 .

[255]  B. Erickson Gene transfer in the environment. , 2001, Environmental science & technology.

[256]  E. Perfect,et al.  Fecal coliform transport through intact soil blocks amended with poultry manure , 1998 .

[257]  S. Jørgensen,et al.  Occurrence, fate and effects of pharmaceutical substances in the environment--a review. , 1998, Chemosphere.

[258]  S. Edberg,et al.  Natural protection of spring and well drinking water against surface microbial contamination. I. Hydrogeological parameters. , 1997, Critical reviews in microbiology.

[259]  Mark D. Sobsey,et al.  Viral and bacterial contamination of groundwater from on-site sewage treatment systems , 1997 .

[260]  Y. Sakai,et al.  Adsorption of viruses in water environment onto solid surfaces , 1997 .

[261]  J. Blahova,et al.  Mobilization of antibiotic resistance for transfer in Pseudomonas aeruginosa. , 1996, Journal of chemotherapy.

[262]  G. Randall,et al.  Effect of liquid manure application methods on soil nitrogen and corn grain yields , 1995 .

[263]  R. Harvey,et al.  Transport of pathogens through soils and aquifers , 1992 .

[264]  P. Mazodier,et al.  Gene transfer between distantly related bacteria. , 1991, Annual review of genetics.

[265]  Debprasad Chattopadhyay,et al.  'DNA' as contaminants in antibiotics and its capacity to transform bacteria to drug resistance. , 1990, Indian journal of experimental biology.

[266]  J. Rose,et al.  Viruses in Source and Drinking Water , 1990 .

[267]  Gordon A. McFeters,et al.  Drinking Water Microbiology , 1990, Brock/Springer Series in Contemporary Bioscience.

[268]  C. Gerba,et al.  Virus removal by drinking water treatment processes , 1989 .

[269]  Marylynn V. Yates,et al.  Modeling microbial fate in the subsurface environment , 1988 .

[270]  C. Gerba,et al.  Viruses in groundwater , 1980 .

[271]  E. Jawetz Antimicrobial chemotherapy. , 1956, Annual review of microbiology.

[272]  C. Gerba,et al.  VIRUS SURVIVAL IN WATER AND WASTEWATER SYSTEMS , 1800 .