Synthesis and antiviral activity of new dimeric inhibitors against HIV-1.

[1]  E. De Clercq,et al.  Synthesis and Antiviral Activities of 1,2,3-triazole Functionalized Thymidines: 1,3-dipolar Cycloaddition for Efficient Regioselective Diversity Generation , 2005, Antiviral chemistry & chemotherapy.

[2]  Christophe Meyer,et al.  Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains. , 2005, Journal of medicinal chemistry.

[3]  R. Hunter,et al.  New methodology for 2-alkylation of 3-furoic acids: application to the synthesis of tethered UC-781/d4T bifunctional HIV reverse-transcriptase inhibitors , 2005 .

[4]  R. Schinazi,et al.  Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series. , 2005, Bioorganic & medicinal chemistry.

[5]  P. T. Jørgensen,et al.  Synthesis and evaluation of double-prodrugs against HIV. Conjugation of D4T with 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine)-type reverse transcriptase inhibitors via the SATE prodrug approach. , 2005, Journal of medicinal chemistry.

[6]  A. Ciurea,et al.  Synthesis of 5-alkynylated d4T Analogues as Potential HIV-1 Reverse Transcriptase Inhibitors , 2004, Journal of enzyme inhibition and medicinal chemistry.

[7]  Rudi Pauwels,et al.  New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections. , 2004, Current opinion in pharmacology.

[8]  Richard Morphy,et al.  From magic bullets to designed multiple ligands. , 2004, Drug discovery today.

[9]  H. Mitsuya,et al.  Potential of 4′-C-Substituted Nucleosides for the Treatment of HIV-1 , 2004, Antiviral chemistry & chemotherapy.

[10]  R. Hamatake,et al.  Clinical Utility of Current NNRTIs and Perspectives of New Agents in This Class under Development , 2004, Antiviral chemistry & chemotherapy.

[11]  C. Nielsen,et al.  Synthesis of Furoannelated Analogues of Emivirine (MKC‐442) , 2004, Archiv der Pharmazie.

[12]  Erik De Clercq,et al.  Non‐Nucleoside Reverse Transcriptase Inhibitors (NNRTIs): Past, Present, and Future , 2004, Chemistry & biodiversity.

[13]  A. Punzi,et al.  A straightforward method for the synthesis of unsymmetrically substituted 1,3-diynes , 2003 .

[14]  J. Imbach,et al.  Synthesis of 3′-Deoxy-3′-[4-(pyrimidin-1-yl)methyl-1,2,3-triazol-1-yl]thymidine via 1,3-Dipolar Cycloaddition , 2003, Nucleosides, nucleotides & nucleic acids.

[15]  C. Nielsen,et al.  Synthesis and evaluation of new potential HIV-1 non-nucleoside reverse transcriptase inhibitors. New analogues of MKC-442 containing Michael acceptors in the C-6 position. , 2003, Organic & biomolecular chemistry.

[16]  E. De Clercq,et al.  N-3 Substituted TSAO Derivatives as a Probe to Explore the Dimeric Interface of HIV-1 Reverse Transcriptase , 2003, Nucleosides, Nucleotides & Nucleic Acids.

[17]  A. Aubertin,et al.  Synthesis of Certain Heterodimers Expected as HIV-1 Reverse Transcriptase Inhibitors , 2003, Nucleosides, nucleotides & nucleic acids.

[18]  L. Agrofoglio,et al.  Palladium-assisted routes to nucleosides. , 2003, Chemical reviews.

[19]  E. Negishi,et al.  Palladium-catalyzed alkynylation. , 2003, Chemical reviews.

[20]  P. T. Jørgensen,et al.  Synthesis of novel N-1 (allyloxymethyl) analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine) with improved activity against HIV-1 and its mutants. , 2002, Journal of medicinal chemistry.

[21]  Erik De Clercq,et al.  New anti‐HIV agents and targets , 2002, Medicinal research reviews.

[22]  Hirokazu Kobayashi,et al.  Synthesis and two-electron redox behavior of diazuleno[2,1-a:1,2-c]naphthalenes. , 2002, The Journal of organic chemistry.

[23]  Luke G Green,et al.  A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. , 2002, Angewandte Chemie.

[24]  S. Taneepanichskul,et al.  Use of Norplant implants in the immediate postpartum period among asymptomatic HIV-1-positive mothers. , 2001, Contraception.

[25]  F. Gago,et al.  Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase. , 2001, Journal of medicinal chemistry.

[26]  E. Pedersen,et al.  Three Routes for the Synthesis of 6-Benzyl-1-ethoxymethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde , 2001 .

[27]  C. Murray,et al.  Synthesis of 1,3-Diynes in the Purine, Pyrimidine, 1,3,5-Triazine and Acridine Series , 2000 .

[28]  P. T. Jørgensen,et al.  Synthesis of annelated analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442) using 1,3-oxazine-2,4(3H)-diones as key intermediates , 2000 .

[29]  E. Pedersen,et al.  Synthesis and anti-HIV-1 activity of novel 2,3-dihydro-7H-thiazolo[3,2-a]pyrimidin-7-ones. , 1998, Journal of medicinal chemistry.

[30]  E. Pedersen,et al.  5,6-Dihydropyrrolo[1,2-c]pyrimidine-1,3(2H,5H)-diones as Annulated Analogues of the Anti-HIV Compound MKC-442 (6-Benzyl-1-(ethoxymethyl)-5-isopropyluracil) , 1997 .

[31]  K. Danel,et al.  Synthesis and potent anti-HIV-1 activity of novel 6-benzyluracil analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine. , 1996, Journal of medicinal chemistry.

[32]  Richard T. Walker,et al.  Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. , 1996, Journal of medicinal chemistry.

[33]  E. Pedersen,et al.  EASY SYNTHESIS OF 5,6-DISUBSTITUTED ACYCLOURIDINE DERIVATIVES , 1995 .

[34]  M. Žinić,et al.  Bis-adeninyl and bis-uracilyl hexadiyne derivatives of nucleobases , 1995 .

[35]  T. Matthews,et al.  Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[36]  J Desmyter,et al.  Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds. , 1988, Journal of virological methods.

[37]  H. Vorbrüggen,et al.  Nucleoside syntheses, XXII1) Nucleoside synthesis with trimethylsilyl triflate and perchlorate as catalysts , 1981 .