The first report in Turkey of in vivo cultivation in Rattus norvegicus of Echinococcus multilocularis human strain.

The adult form of the small cestode Echinococcus multilocularis is found in carnivorous animals, especially in the fox. This cestode, which is found in the northern hemisphere in the world, is the cause of a generally fatal disease in humans, known as alveolar echinococcosis (AE). The metacestodes of Echinococcus multilocularis can be experimentally developed in the Meriones unguiculatus species of rodents, and it is possible to use these metacestodes for numerous purposes, primarily for supplying the antigens required for serological diagnosis of the disease. It is with this aim that in this study for the first time in Turkey, Echinococcus multilocularis metacestodes were developed using different kind of rodent, Rattus norvegicus, and an indigenous strain was isolated using the surgical material of a patient diagnosed with alveolar echinococcosis.

[1]  A. Mavi,et al.  The ability of67ga scintigraphy to detect the lesions ofEchinococcus multilocularis infection: Preliminary results , 2006, Annals of nuclear medicine.

[2]  A. Uner,et al.  A new technique to avoid losing the strains of Echinococcus multilocularis during passaging. , 2005, Saudi medical journal.

[3]  A. Uner,et al.  The first report of Echinococcus multilocularis strain isolation from human in Turkey. , 2005, Turkiye parazitolojii dergisi.

[4]  A. Uner,et al.  Use of Two Sensitive and Specific Immunoblot Markers, Em70 and Em90, for Diagnosis of Alveolar Echinococcosis , 2004, Journal of Clinical Microbiology.

[5]  A. Hemphill,et al.  Immunology and morphology studies on the proliferation of in vitro cultivatedEchinococcus multilocularis metacestodes , 2004, Parasitology Research.

[6]  M. Hildreth,et al.  EFFECT OF MOUSE STRAIN VARIATIONS AND CORTISONE TREATMENT ON THE ESTABLISHMENT AND GROWTH OF PRIMARY ECHINOCOCCUS MULTILOCULARIS HYDATID CYSTS , 2003, The Journal of parasitology.

[7]  A. Hemphill,et al.  Culture of Echinococcus multilocularis metacestodes: an alternative to animal use. , 2002, Trends in parasitology.

[8]  H. Auer,et al.  Domestic pets as risk factors for alveolar hydatid disease in Austria. , 1998, American journal of epidemiology.

[9]  L. Liao,et al.  [Comparative observation on experimental infection with Echinococcus multilocularis in Cricetulus Migratorius and Meriones meridianus]. , 1998, Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases.

[10]  M. Okamoto,et al.  Antibody responses against Echinococcus multilocularis antigens in naturally infected Rattus norvegicus , 1996, Journal of Helminthology.

[11]  H. Auer,et al.  Skin localization of alveolar echinococcosis of the liver. , 1996, Journal of the American Academy of Dermatology.

[12]  Prof.Dr. İbrahim Öztek Ekinokokkus Alveolaris Parazitliği , 1995 .

[13]  D. Sturm,et al.  Interleukin-5 is the predominant cytokine produced by peripheral blood mononuclear cells in alveolar echinococcosis , 1995, Infection and immunity.

[14]  G. Barnish,et al.  A large focus of alveolar echinococcosis in central China , 1992, The Lancet.

[15]  B. Gottstein Echinococcus multilocularis infection: immunology and immunodiagnosis. , 1992, Advances in parasitology.