Compact CMOS amperometric readout for nanopore arrays in high throughput lab-on-CMOS

In depth characterization of nanopores such as ion channel proteins holds great value for medical and pharmaceutical applications. In this paper, an electrochemical interface circuit (EIC) is presented that enables both readout of individual nanopores and high throughput implementation within a lab-on-CMOS array platform. The EIC was designed for an electrochemical array microsystem that would facilitate proteomics research via parallel characterization of multiple ion channel proteins with single channel resolution. Fabricated in 0.5 μm AMI CMOS, the EIC can record rapid and extremely weak ion channel current pulses within a very noisy environment. Measurements show that the circuit can detect currents as low as 10 pA with a pulse width of 10 μsec. The readout circuit is low power and very compact to facilitate up to 1024 channels on a large CMOS chip.

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