O6-Methylguanine-DNA Methyltransferase Leu84Phe and Ile143Val Polymorphisms and Risk of Colorectal Cancer in the Nurses’ Health Study and Physicians’ Health Study (United States)
暂无分享,去创建一个
D. Hunter | E. Giovannucci | L. Samson | C. Fuchs | G. Tranah | Jing Ma | L. Hines | Lisa H. Hines | J. Bugni | Jing Ma | D. Hunter
[1] S. Lewis,et al. Quantitative trait locus analysis reveals two intragenic sites that influence O6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells. , 2005, Carcinogenesis.
[2] D. Grobbee,et al. Alcohol and endogenous sex steroid levels in postmenopausal women: a cross-sectional study. , 2005, The Journal of clinical endocrinology and metabolism.
[3] M. Bertagnolli,et al. Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer. , 2004, Carcinogenesis.
[4] E. Giovannucci. Alcohol, one-carbon metabolism, and colorectal cancer: recent insights from molecular studies. , 2004, The Journal of nutrition.
[5] N. Cook,et al. Body Mass Index and Risk of Colorectal Cancer in Women (United States) , 2004, Cancer Causes & Control.
[6] S. Ma,et al. O6-methylguanine-DNA-methyltransferase expression and gene polymorphisms in relation to chemotherapeutic response in metastatic melanoma , 2003, British Journal of Cancer.
[7] R Alexandra Goldbohm,et al. Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer. , 2003, Cancer research.
[8] G. Margison,et al. Variability and regulation of O6-alkylguanine-DNA alkyltransferase. , 2003, Carcinogenesis.
[9] J. Potter,et al. Body mass index and colon cancer: an evaluation of the modifying effects of estrogen (United States) , 2003, Cancer Causes & Control.
[10] E. Giovannucci. Diet, body weight, and colorectal cancer: a summary of the epidemiologic evidence. , 2003, Journal of women's health.
[11] M. Bertagnolli,et al. 2-Methoxyestradiol induces p53-associated apoptosis of colorectal cancer cells. , 2002, Cancer letters.
[12] R. Kaaks,et al. Obesity , Endogenous Hormones , and Endometrial Cancer Risk : A Synthetic Review 1 , 2002 .
[13] D. Cooper,et al. DNA alkylation and repair in the large bowel: animal and human studies. , 2002, The Journal of nutrition.
[14] S. Ma,et al. Novel O6‐methylguanine‐DNA methyltransferase SNPs: A frequency comparison of patients with familial melanoma and healthy individuals in Sweden , 2002, Human mutation.
[15] A. Miller,et al. Obesity and colorectal cancer risk in women , 2002, Gut.
[16] E. Giovannucci,et al. Obesity, gender, and colon cancer , 2002, Gut.
[17] L. Anderson,et al. DNA adducts and liver DNA replication in rats during chronic exposure to N-nitrosodimethylamine (NDMA) and their relationships to the dose-dependence of NDMA hepatocarcinogenesis. , 2002, Mutation research.
[18] E. Giovannucci. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. , 2001, The Journal of nutrition.
[19] A. K. Teo,et al. The Modified Human DNA Repair EnzymeO6-Methylguanine-DNA Methyltransferase Is a Negative Regulator of Estrogen Receptor-Mediated Transcription upon Alkylation DNA Damage , 2001, Molecular and Cellular Biology.
[20] H. Bartsch,et al. Ethanol enhances the formation of endogenously and exogenously derived adducts in rat hepatic DNA. , 2001, Mutation research.
[21] J. Herman,et al. Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. , 2001, Cancer research.
[22] M. Bertagnolli,et al. Reciprocal Expression of ERα and ERβ Is Associated with Estrogen-mediated Modulation of Intestinal Tumorigenesis , 2001 .
[23] T. Key,et al. Energy balance and cancer: the role of sex hormones , 2001, The Proceedings of the Nutrition Society.
[24] J. Tainer,et al. Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase. , 2000, Mutation research.
[25] J. Herman,et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. , 2000, Cancer research.
[26] A. Pegg. Repair of O6-alkylguanine by alkyltransferases , 2000 .
[27] J. Gaughan,et al. Role of polymorphisms in codons 143 and 160 of the O6-alkylguanine DNA alkyltransferase gene in lung cancer risk. , 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
[28] Y. Nakabeppu,et al. Characterization of human polymorphic DNA repair methyltransferase. , 2000, Pharmacogenetics.
[29] M. Brandi,et al. Estrogen synthesis in human colon cancer epithelial cells , 1999, The Journal of Steroid Biochemistry and Molecular Biology.
[30] H. Sasano,et al. Aromatase in aging women. , 1999, Seminars in reproductive endocrinology.
[31] W. Lijinsky. N-Nitroso compounds in the diet. , 1999, Mutation research.
[32] M. Hewison,et al. Loss of estrogen inactivation in colonic cancer. , 1999, The Journal of clinical endocrinology and metabolism.
[33] F. Grodstein,et al. Postmenopausal hormone therapy and the risk of colorectal cancer: a review and meta-analysis. , 1999, The American journal of medicine.
[34] P. Knekt,et al. Risk of colorectal and other gastro‐intestinal cancers after exposure to nitrate, nitrite and N‐nitroso compounds: a follow‐up study , 1999, International journal of cancer.
[35] S. Hecht,et al. DNA adduct formation from tobacco-specific N-nitrosamines. , 1999, Mutation research.
[36] J. Herman,et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. , 1999, Cancer research.
[37] D. Xie,et al. Genetic polymorphism of human O6-alkylguanine-DNA alkyltransferase: identification of a missense variation in the active site region. , 1999, Pharmacogenetics.
[38] W. Willett,et al. A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma. , 1998, Carcinogenesis.
[39] F. Speizer,et al. Multivitamin Use, Folate, and Colon Cancer in Women in the Nurses' Health Study , 1998, Annals of Internal Medicine.
[40] J. Manson,et al. A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer. , 1997, Carcinogenesis.
[41] D. Cooper,et al. Low O6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC-->AT transition in the K-ras oncogene. , 1997, Carcinogenesis.
[42] A. Bilancio,et al. Estradiol activation of human colon carcinoma-derived Caco-2 cell growth. , 1996, Cancer research.
[43] A. K. Teo,et al. Conformational change in human DNA repair enzyme O6-methylguanine-DNA methyltransferase upon alkylation of its active site by SN1 (indirect-acting) and SN2 (direct-acting) alkylating agents: breaking a "salt-link". , 1996, Biochemistry.
[44] A. Siitonen,et al. In vitro alcohol dehydrogenase-mediated acetaldehyde production by aerobic bacteria representing the normal colonic flora in man. , 1996, Alcoholism, clinical and experimental research.
[45] A. Pegg,et al. Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase. , 1996, Mutation research.
[46] W. Willett,et al. Physical activity, obesity, and risk of colorectal adenoma in women (United States) , 1996, Cancer Causes & Control.
[47] T. Ishikawa,et al. A polymorphism at codon 160 of human O6-methylguanine-DNA methyltransferase gene in young patients with adult type cancers and functional assay. , 1995, Carcinogenesis.
[48] G A Colditz,et al. Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women. , 1995, Journal of the National Cancer Institute.
[49] J. Tentler,et al. Acute ethanol exposure suppresses the repair of O6-methylguanine DNA lesions in castrated adult male rats. , 1994, Alcoholism, clinical and experimental research.
[50] A. Pegg,et al. A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine. , 1993, Cancer research.
[51] C. Conover,et al. Regulation and Function of Insulin-Like Growth Factor-Binding Protein-1 , 1993, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[52] W. Willett,et al. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. , 1992, JAMA.
[53] D. Powell,et al. Insulin inhibits transcription of the human gene for insulin-like growth factor-binding protein-1. , 1991, The Journal of biological chemistry.
[54] Richard B. Hayes,et al. O6-Methylguanine-DNA Methyltransferase and uracil DNA glycosylase in human broncho-alveolar lavage cells and peripheral blood mononuclear cells from tobacco smokers and non-smokers , 1991 .
[55] A. Pegg,et al. Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. , 1990, Cancer research.
[56] C. Lieber,et al. In vitro and in vivo inhibitory effect of ethanol and acetaldehyde on O6-methylguanine transferase. , 1988, Carcinogenesis.
[57] T. Lindahl,et al. Suicide inactivation of the E. coli O6‐methylguanine‐DNA methyltransferase. , 1982, The EMBO journal.
[58] J. Potter,et al. Reproduction, endogenous and exogenous sex hormones, and colon cancer: a review and hypothesis. , 1980, Journal of the National Cancer Institute.
[59] S. Shany,et al. Estrogen controls expression and bioresponse of 1,25-dihydroxyvitamin D receptors in the rat colon , 2004, Molecular and Cellular Biochemistry.
[60] M. Bertagnolli,et al. Reciprocal expression of ERalpha and ERbeta is associated with estrogen-mediated modulation of intestinal tumorigenesis. , 2001, Cancer research.
[61] A. Pegg. Repair of O(6)-alkylguanine by alkyltransferases. , 2000, Mutation research.
[62] S. Shany,et al. The protective effect of estrogen against chemically induced murine colon carcinogenesis is associated with decreased CpG island methylation and increased mRNA and protein expression of the colonic vitamin D receptor. , 1999, Oncology research.
[63] S. Baylin,et al. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon , 1994, Nature Genetics.
[64] R. Hayes,et al. O(6)-methylguanine-DNA methyltransferase and uracil DNA glycosylase in human broncho-alveolar lavage cells and peripheral blood mononuclear cells from tobacco smokers and non-smokers. , 1991, Carcinogenesis.
[65] Y. Nakabeppu,et al. Regulation and expression of the adaptive response to alkylating agents. , 1988, Annual review of biochemistry.