Effects of melatonin on the oxidant/antioxidant status and lung histopathology in rabbits exposed to cigarette smoke

Objectives and background:  To evaluate the effects of cigarette smoking on the histopathology and the oxidant/antioxidant status of the lungs and to test the potential antioxidant benefits of melatonin on these induced changes.

[1]  M. Muñoz,et al.  Hepato- and neurotoxicity induced by thioacetamide: protective effects of melatonin and dimethylsulfoxide. , 2005, Pharmacological research.

[2]  Barbara Buffoli,et al.  Protective role of melatonin in cyclosporine A-induced oxidative stress in rat liver. , 2005, International immunopharmacology.

[3]  Fehmi Ozguner,et al.  Oxidative damage in the kidney induced by 900-MHz-emitted mobile phone: protection by melatonin. , 2005, Archives of medical research.

[4]  A. Korkmaz,et al.  Melatonin ameliorates bladder damage induced by cyclophosphamide in rats , 2005, Journal of pineal research.

[5]  E. Vara,et al.  Effect of melatonin administration on parameters related to oxidative damage in hepatocytes isolated from old Wistar rats , 2005, Journal of pineal research.

[6]  K. Brismar,et al.  Influence of cigarette smoking on melatonin levels in man , 2005, European Journal of Clinical Pharmacology.

[7]  N. Altinors,et al.  Effect of melatonin on cerebral vasospasm following experimental subarachnoid hemorrhage , 2005, Neurological research.

[8]  R. Baybutt,et al.  Vitamin A depletion induced by cigarette smoke is associated with the development of emphysema in rats. , 2003, The Journal of nutrition.

[9]  X. Weng,et al.  Beta-carotene protects rats against bronchitis induced by cigarette smoking. , 2003, Chinese medical journal.

[10]  B. Yeğen,et al.  Melatonin improves oxidative organ damage in a rat model of thermal injury. , 2002, Burns : journal of the International Society for Burn Injuries.

[11]  H. Aksoy,et al.  The Changes of Superoxide Dismutase, Catalase and Glutathione Peroxidase Activities in Erythrocytes of Active and Passive Smokers , 2002, Clinical chemistry and laboratory medicine.

[12]  R. B. Walker,et al.  The identification of the UV degradants of melatonin and their ability to scavenge free radicals , 2002, Journal of pineal research.

[13]  A. Meki,et al.  Melatonin reduces oxidative stress induced by ochratoxin A in rat liver and kidney. , 2001, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[14]  Ş. Tamer,et al.  Oxidant–antioxidant profiles of platelet rich plasma in smokers , 2001, Addiction biology.

[15]  J. Seagrave OXIDATIVE MECHANISMS IN TOBACCO SMOKE-INDUCED EMPHYSEMA , 2000, Journal of toxicology and environmental health. Part A.

[16]  W. MacNee,et al.  Localization of gamma-glutamylcysteine synthetase messenger rna expression in lungs of smokers and patients with chronic obstructive pulmonary disease. , 2000, Free radical biology & medicine.

[17]  M. Paiva,et al.  N-acetylcysteine prevents cigarette smoke induced small airways alterations in rats. , 2000, The European respiratory journal.

[18]  W. MacNee,et al.  Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease. , 1999, American journal of respiratory and critical care medicine.

[19]  J. Freischlag,et al.  Ascorbic acid prevents cigarette smoke injury to endothelium-dependent arterial relaxation. , 1999, The Journal of surgical research.

[20]  A. Rotta,et al.  Partial liquid ventilation influences pulmonary histopathology in an animal model of acute lung injury. , 1999, Journal of critical care.

[21]  W. MacNee,et al.  Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. , 1999, American journal of respiratory and critical care medicine.

[22]  J. Slot,et al.  Transgenic models for the study of lung antioxidant defense: enhanced manganese-containing superoxide dismutase activity gives partial protection to B6C3 hybrid mice exposed to hyperoxia. , 1998, American journal of respiratory cell and molecular biology.

[23]  I. Antolín,et al.  Antioxidative protection in a high‐melatonin organism: The dinoflagellate Gonyaulax polyedra is rescued from lethal oxidative stress by strongly elevated, but physiologically possible concentrations of melatonin , 1997, Journal of pineal research.

[24]  J. T. Saari,et al.  Catalase-overexpressing transgenic mouse heart is resistant to ischemia-reperfusion injury. , 1997, The American journal of physiology.

[25]  R. Reiter,et al.  Acutely administered melatonin reduces oxidative damage in lung and brain induced by hyperbaric oxygen. , 1997, Journal of applied physiology.

[26]  W. Pryor Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity. , 1997, Environmental health perspectives.

[27]  S. Thom,et al.  Release of glutathione from erythrocytes and other markers of oxidative stress in carbon monoxide poisoning. , 1997, Journal of applied physiology.

[28]  J. L. Hong,et al.  Cigarette smoke-induced bronchoconstriction: causative agents and role of thromboxane receptors. , 1996, Journal of applied physiology.

[29]  A Cerioli,et al.  Environmental tobacco smoke. , 1996, Environmental health perspectives.

[30]  C. Cross,et al.  Dietary antioxidants and cigarette smoke-induced biomolecular damage: a complex interaction. , 1995, The American journal of clinical nutrition.

[31]  W. Pryor,et al.  Detection of free radicals in aqueous extracts of cigarette tar by electron spin resonance. , 1995, Free radical biology & medicine.

[32]  G. FitzGerald,et al.  Cylooxygenase-dependent Formation of the Isoprostane, 8-Epi Prostaglandin F2α(*) , 1995, The Journal of Biological Chemistry.

[33]  G. FitzGerald,et al.  Cyclooxygenase‐Dependent Formation of the Isoprostane 8‐EPI Prostaglandin F2α a , 1994, The Journal of biological chemistry.

[34]  H. Sekhon,et al.  Cigarette smoke causes rapid cell proliferation in small airways and associated pulmonary arteries. , 1994, The American journal of physiology.

[35]  A. Penn,et al.  Inhalation of Steady‐State Sidestream Smoke From One Cigarette Promotes Arteriosclerotic Plaque Development , 1994, Circulation.

[36]  B. Tarquini,et al.  Daytime Circulating Melatonin Levels in Smokers , 1994, Tumori.

[37]  William A. Pryor,et al.  Cigarette smoke chemistry: conversion of nitric oxide to nitrogen dioxide and reactions of nitrogen oxides with other smoke components as studied by Fourier transform infrared spectroscopy , 1994 .

[38]  M. Lamy-Freund,et al.  High melatonin solubility in aqueous medium , 1994, Journal of pineal research.

[39]  C. Cross,et al.  Cigarette Smoke Oxidation of Human Plasma Constituents a , 1993, Annals of the New York Academy of Sciences.

[40]  J. Diana,et al.  Tobacco Smoking and Nutrition , 1993, Annals of the New York Academy of Sciences.

[41]  R. Reiter,et al.  Pineal melatonin: cell biology of its synthesis and of its physiological interactions. , 1991, Endocrine reviews.

[42]  H. Mehendale,et al.  Glutathione metabolism and utilization of external thiols by cigarette smoke-challenged, isolated rat and rabbit lungs. , 1988, Toxicology and applied pharmacology.

[43]  A. Swaak,et al.  Intracellular and extracellular sulphydryl levels in rheumatoid arthritis. , 1986, Annals of the rheumatic diseases.

[44]  A. Molteni,et al.  Monocrotaline-Induced Pulmonary Fibrosis in Rats: Amelioration by Captopril and Penicillamine , 1985, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[45]  K. Yagi,et al.  Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. , 1979, Analytical biochemistry.

[46]  R. Sandhir,et al.  Long-term smoking and ethanol exposure accentuates oxidative stress in hearts of mice , 2007, Cardiovascular Toxicology.

[47]  J. Freischlag,et al.  Cigarette smoke impairs endothelium-dependent relaxation in rabbit superficial femoral veins. , 1999, The Journal of surgical research.

[48]  M. Kaçmaz,et al.  Acute and Chronic Effects of Smoking on Blood Antioxidant Status , 1999 .

[49]  W. MacNee,et al.  Role of oxidants/antioxidants in smoking-induced lung diseases. , 1996, Free radical biology & medicine.

[50]  P. Leanderson,et al.  Cigarette smoke-induced DNA damage in cultured human lung cells: role of hydroxyl radicals and endonuclease activation. , 1992, Chemico-biological interactions.

[51]  E. Stadtman,et al.  Determination of carbonyl content in oxidatively modified proteins. , 1990, Methods in enzymology.

[52]  W. Pryor,et al.  Quantitative analysis of the hydrogen peroxide formed in aqueous cigarette tar extracts. , 1989, Free radical biology & medicine.