c-Myc phosphorylation is required for cellular response to oxidative stress.

[1]  M. Eilers,et al.  Transcriptional regulation and transformation by Myc proteins , 2005, Nature Reviews Molecular Cell Biology.

[2]  Javier León,et al.  Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes , 2005, Oncogene.

[3]  S. McMahon,et al.  Analysis of genomic targets reveals complex functions of MYC , 2004, Nature Reviews Cancer.

[4]  K. Nakayama,et al.  Phosphorylation‐dependent degradation of c‐Myc is mediated by the F‐box protein Fbw7 , 2004, The EMBO journal.

[5]  K. Helin,et al.  Loss of MYC Confers Resistance to Doxorubicin-induced Apoptosis by Preventing the Activation of Multiple Serine Protease- and Caspase-mediated Pathways* , 2004, Journal of Biological Chemistry.

[6]  G. Zupi,et al.  Glutathione depletion induced by c-Myc downregulation triggers apoptosis on treatment with alkylating agents. , 2004, Neoplasia.

[7]  Joseph R. Nevins,et al.  A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells , 2004, Nature Cell Biology.

[8]  John L Cleveland,et al.  Myc pathways provoking cell suicide and cancer , 2003, Oncogene.

[9]  J. Cleveland,et al.  c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XL , 2003, Molecular and Cellular Biology.

[10]  E. Appella,et al.  Phosphorylation Site Interdependence of Human p53 Post-translational Modifications in Response to Stress* , 2003, Journal of Biological Chemistry.

[11]  Kathryn A. O’Donnell,et al.  An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets , 2003, Genome Biology.

[12]  Andrea Cocito,et al.  Genomic targets of the human c-Myc protein. , 2003, Genes & development.

[13]  Terence P. Speed,et al.  A comparison of normalization methods for high density oligonucleotide array data based on variance and bias , 2003, Bioinform..

[14]  Y. Yoo,et al.  c-Myc exerts a protective function through ornithine decarboxylase against cellular insults. , 2002, Molecular pharmacology.

[15]  G. Zupi,et al.  Glutathione Influences c-Myc-induced Apoptosis in M14 Human Melanoma Cells* , 2002, The Journal of Biological Chemistry.

[16]  G. Hart,et al.  Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: alternative glycosylation/phosphorylation of THR-58, a known mutational hot spot of c-Myc in lymphomas, is regulated by mitogens. , 2002, The Journal of biological chemistry.

[17]  G. Wahl,et al.  c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. , 2002, Molecular cell.

[18]  C. Albanese,et al.  E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination. , 2002, Molecular cell.

[19]  Arthur James Cooper,et al.  γ‐Glutamylcysteine Synthetase , 2002 .

[20]  G. Zupi,et al.  c-Myc down-regulation increases susceptibility to cisplatin through reactive oxygen species-mediated apoptosis in M14 human melanoma cells. , 2001, Molecular pharmacology.

[21]  D. Andrews,et al.  Myc Potentiates Apoptosis by Stimulating Bax Activity at the Mitochondria , 2001, Molecular and Cellular Biology.

[22]  I. D'Agnano,et al.  Myc down-regulation induces apoptosis in M14 melanoma cells by increasing p27kip1 levels , 2001, Oncogene.

[23]  M. Czaja,et al.  Inhibition of c-Myc Expression Sensitizes Hepatocytes to Tumor Necrosis Factor-induced Apoptosis and Necrosis* , 2000, The Journal of Biological Chemistry.

[24]  Y Taya,et al.  Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. , 2000, Genes & development.

[25]  M. Cole,et al.  The c-Myc Transactivation Domain Is a Direct Modulator of Apoptotic versus Proliferative Signals , 2000, Molecular and Cellular Biology.

[26]  M. Gregory,et al.  c-Myc Proteolysis by the Ubiquitin-Proteasome Pathway: Stabilization of c-Myc in Burkitt's Lymphoma Cells , 2000, Molecular and Cellular Biology.

[27]  R. Mulcahy,et al.  Regulation of γ-glutamylcysteine synthetase subunit gene expression: Insights into transcriptional control of antioxidant defenses , 2000, Free radical research.

[28]  Yoshiyuki Kuchino,et al.  Regulation of c-Myc through Phosphorylation at Ser-62 and Ser-71 by c-Jun N-Terminal Kinase* , 1999, The Journal of Biological Chemistry.

[29]  D. Roop,et al.  Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis , 1999, Oncogene.

[30]  Moinova Hr,et al.  Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element. , 1999 .

[31]  Chi V. Dang,et al.  c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism , 1999, Molecular and Cellular Biology.

[32]  B. Hoffman,et al.  The proto-oncogene c-myc and apoptosis , 1998, Oncogene.

[33]  Moinova Hr,et al.  An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site. , 1998 .

[34]  A. C. Wild,et al.  Overlapping antioxidant response element and PMA response element sequences mediate basal and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase catalytic subunit gene. , 1998, The Biochemical journal.

[35]  R. Mulcahy,et al.  Constitutive and β-Naphthoflavone-induced Expression of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene Is Regulated by a Distal Antioxidant Response Element/TRE Sequence* , 1997, The Journal of Biological Chemistry.

[36]  J. Cleveland,et al.  c-Myc and apoptosis. , 1995, Biochimica et biophysica acta.

[37]  R. Mulcahy,et al.  Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues. , 1995, Biochemical and biophysical research communications.

[38]  A Ma,et al.  Binding of myc proteins to canonical and noncanonical DNA sequences , 1993, Molecular and cellular biology.

[39]  B. Fanburg,et al.  Regulation of cellular glutathione. , 1989, The American journal of physiology.

[40]  A. Meister,et al.  Gamma-glutamylcysteine synthetase. Interactions of an essential sulfhydryl group. , 1984, The Journal of biological chemistry.

[41]  R. Mulcahy,et al.  Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element. , 1999, Biochemical and biophysical research communications.

[42]  R. Mulcahy,et al.  An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site. , 1998, The Journal of biological chemistry.

[43]  E. Thompson,et al.  The many roles of c-Myc in apoptosis. , 1998, Annual review of physiology.

[44]  J. Woodgett,et al.  Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo. , 1994, Oncogene.