Biosensors based on nucleic acid interaction

DNA sensing is an emerging technology based on hybridisation reaction between an immobilised DNA probe and a molecular target, consisting of a probe complementary sequence in solution. Many application have been developed in the field of environmental, food and clinical analysis. Surface plasmon resonance and piezoelectric sensing are reported as transduction principles for DNA-based devices. These techniques are able to monitor in real-time and without the use of any label the hybridisation reaction between nucleic acids. Particular attention is given to Genetically Modified Organism detection.

[1]  S Tombelli,et al.  Coupling of a DNA piezoelectric biosensor and polymerase chain reaction to detect apolipoprotein E polymorphisms. , 2000, Biosensors & bioelectronics.

[2]  Susan R. Mikkelsen,et al.  Electrochecmical biosensors for DNA sequence detection , 1996 .

[3]  Sara Tombelli,et al.  A DNA piezoelectric biosensor assay coupled with a polymerase chain reaction for bacterial toxicity determination in environmental samples , 2000 .

[4]  Maria Minunni,et al.  The Quartz Crystal Microbalance as Biosensor. A Status Report on Its Future , 1995 .

[5]  M. Minunni.  Simultaneous determination of β2-microglobulin and Ig E using real-time Biospecific Interaction Analysis (BIA) , 1995 .

[6]  Bo Johnsson,et al.  A novel hydrogel matrix on gold surfaces in surface plasmon resonance sensors for fast and efficient covalent immobilization of ligands , 1990 .

[7]  S Tombelli,et al.  Biosensors as new analytical tool for detection of Genetically Modified Organisms (GMOs) , 2001, Fresenius' journal of analytical chemistry.

[8]  G. Marrazza,et al.  Disposable DNA electrochemical sensor for hybridization detection. , 1999, Biosensors & bioelectronics.

[9]  Joseph Wang,et al.  Screen‐printed electrochemical hybridization biosensor for the detection of DNA sequences from the Escherichia coli pathogen , 1997 .

[10]  Damià Barceló,et al.  Environmental applications of analytical biosensors , 1996 .

[11]  M. Mascini,et al.  Immunosensors Based on Piezoelectric Crystal Device , 1998 .

[12]  T. Vo‐Dinh,et al.  Biosensors and biochips: advances in biological and medical diagnostics , 2000, Fresenius' journal of analytical chemistry.

[13]  I Karube,et al.  Application of peptide nucleic acid to the direct detection of deoxyribonucleic acid amplified by polymerase chain reaction. , 1999, Biosensors & bioelectronics.

[14]  M. Mascini,et al.  Piezoelectric Quartz Crystal Biosensors: Recent Immobilisation Schemes , 2000 .

[15]  Sara Tombelli,et al.  A PIEZOELECTRIC AFFINITY BIOSENSOR FOR GENETICALLY MODIFIED ORGANISMS (GMOs) DETECTION , 2001 .

[16]  Maria Minunni,et al.  Surface plasmon resonance biosensor for genetically modified organisms detection , 2002 .

[17]  Kagan Kerman,et al.  DNA Electrochemical Biosensor for the Detection of Short DNA Sequences Related to the Hepatitis B Virus , 1999 .

[18]  Sara Tombelli,et al.  Quartz crystal microbalance (QCM) affinity biosensor for genetically modified organisms (GMOs) detection. , 2003, Biosensors & bioelectronics.

[19]  Gustavo Rivas,et al.  DNA electrochemical biosensors for environmental monitoring. A review , 1997 .

[20]  Maria Minunni,et al.  Detection of Pesticide in Drinking Water Using Real-Time Biospecific Interaction Analysis (BIA) , 1993 .