Therapeutic Exercise in the Treatment of Primary Dysmenorrhea: A Systematic Review and Meta-Analysis.

BACKGROUND Dysmenorrhea is a health problem with a high impact on health and society. Some drugs have been shown to be effective at treating dysmenorrhea. Therapeutic exercise is another option for reducing the symptomatology of this health problem, with a low cost and the absence of side effects. PURPOSE The purposes of this review were to study the efficacy of physical exercise for pain intensity in primary dysmenorrhea and to assess its effectiveness in decreasing the duration of pain and improving quality of life. DATA SOURCES Searches were conducted between February 2017 and May 2017 in the databases Web of Science, Physiotherapy Evidence Database (PEDro), PubMed, Scopus, CINAHL, and Dialnet, using the terms dysmenorrhea, exercise therapy, exercise movement technique, exercise, physical therapy, physical therapy speciality, treatment, primary dysmenorrhea, prevention, etiology, epidemiology, and pain. STUDY SELECTION We included randomized controlled trial studies conducted on women who were 16 to 25 years old and had primary dysmenorrhea, studies that included exercise as a type of therapy, studies that assessed the intensity and duration of pain and quality of life, and studies published in English or Spanish. Studies that included women with irregular cycles, women diagnosed with a gynecological disease, women who had had surgery, women with serious diseases, or women who used intracavitary or oral contraceptives were excluded. We started with 455 studies; 16 were included in the systematic review, and 11 were included in the 3 meta-analyses that were carried out. DATA EXTRACTION Two authors selected the studies and extracted their characteristics (participants, intervention, comparators, and outcomes) and results. The evaluation of the methodological quality of the studies was carried out by PEDro scale. DATA SYNTHESIS There was moderate evidence that therapeutic exercise can be considered a useful tool in the treatment of primary dysmenorrhea in terms of a reduction in pain intensity. Regarding the duration of pain and quality of life, there was low evidence and very low evidence, respectively. In the 3 meta-analyses, the results were significantly positive in favor of exercise for decreases in both the intensity and the duration of pain. LIMITATIONS Limitations of this study include the great heterogeneity of the interventions applied in the studies in terms of type of exercise, in combination or alone, and dosage. This review includes a small number of studies with risk of bias, so the present findings must be interpreted with caution. CONCLUSIONS Therapeutic exercise reduces pain intensity in patients with primary dysmenorrhea.

[1]  A. Daley,et al.  Physical activity for primary dysmenorrhea: a systematic review and meta‐analysis of randomized controlled trials , 2018, American journal of obstetrics and gynecology.

[2]  A. Effenberg,et al.  Effect of rhythmic auditory cueing on parkinsonian gait: A systematic review and meta-analysis , 2018, Scientific Reports.

[3]  G. Edelstam,et al.  Minimal clinically important difference for pain on the VAS scale and the relation to quality of life in women with endometriosis. , 2017, Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives.

[4]  W. Siritaratiwat,et al.  Effect of yoga on the menstrual pain, physical fitness, and quality of life of young women with primary dysmenorrhea. , 2017, Journal of bodywork and movement therapies.

[5]  A. Alipour,et al.  Use of ginger versus stretching exercises for the treatment of primary dysmenorrhea: a randomized controlled trial. , 2017, Journal of integrative medicine.

[6]  R. A. Moore,et al.  فعالیت فیزیکی و ورزش برای درد مزمن در بزرگسالان: یک بررسی اجمالی در مقالات مروری کاکرین , 2017 .

[7]  A. Alipour,et al.  Comparison of the Effect of Stretching Exercises and Mefenamic Acid on the Reduction of Pain and Menstruation Characteristics in Primary Dysmenorrhea: A Randomized Clinical Trial. , 2017, Oman medical journal.

[8]  U. Abaraogu Effectiveness of exercise therapy on pain and quality of life of patients with primary dysmenorrhea: a systematic review with meta-analysis , 2016 .

[9]  N. Zare,et al.  Comparison of the effects of acupressure and self-care behaviors training on the intensity of primary dysmenorrhea based on McGill pain questionnaire among Shiraz University students , 2016, Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences.

[10]  N. Verma,et al.  EFFECT OF EXERCISES ON PRIMARY DYSMENORRHOEA IN YOUNG FEMALES , 2016 .

[11]  N. Yang,et al.  Effects of a Yoga Program on Menstrual Cramps and Menstrual Distress in Undergraduate Students with Primary Dysmenorrhea: A Single-Blind, Randomized Controlled Trial. , 2016, Journal of alternative and complementary medicine.

[12]  I. Esen,et al.  Menstrual Characteristics of Pubertal Girls: A Questionnaire-Based Study in Turkey , 2016, Journal of clinical research in pediatric endocrinology.

[13]  A. Sutar,et al.  Effect of aerobic exercises on primary dysmenorrhoea in college students , 2016 .

[14]  N. Tariq,et al.  Menstrual syndrome: severity, frequency and symptomatology in adolescent girls of Quetta, Pakistan. , 2016 .

[15]  Nahal Habibi,et al.  Prevalence of Primary Dysmenorrhea and Factors Associated with Its Intensity Among Undergraduate Students: A Cross-Sectional Study. , 2015, Pain management nursing : official journal of the American Society of Pain Management Nurses.

[16]  M. Sayadi,et al.  Comparison of the Effect of Massage Therapy and Isometric Exercises on Primary Dysmenorrhea: A Randomized Controlled Clinical Trial. , 2015, Journal of pediatric and adolescent gynecology.

[17]  M. Ortiz,et al.  Effect of a physiotherapy program in women with primary dysmenorrhea. , 2015, European journal of obstetrics, gynecology, and reproductive biology.

[18]  Fiona C Baker,et al.  What we know about primary dysmenorrhea today: a critical review. , 2015, Human reproduction update.

[19]  U. Abaraogu,et al.  As Acupressure Decreases Pain, Acupuncture May Improve Some Aspects of Quality of Life for Women with Primary Dysmenorrhea: A Systematic Review with Meta-Analysis. , 2015, Journal of acupuncture and meridian studies.

[20]  C. Chapple,et al.  Vigorous exercises in the management of primary dysmenorrhea: a feasibility study , 2015, Disability and rehabilitation.

[21]  Kazutoshi Nakamura,et al.  Prevalence of dysmenorrhea and its correlating lifestyle factors in Japanese female junior high school students. , 2015, The Tohoku journal of experimental medicine.

[22]  G. Baxter,et al.  Menstrual pain and quality of life in women with primary dysmenorrhea: Rationale, design, and interventions of a randomized controlled trial of effects of a treadmill-based exercise intervention. , 2015, Contemporary clinical trials.

[23]  M. Sayadi,et al.  The Effect of Isometric Exercises on Primary Dysmenorrhea: A Randomized Controlled Clinical Trial , 2015, Galen Medical Journal.

[24]  N. S. Patel,et al.  Effect of Active Stretching Exercises on Primary Dysmenorrhea in College Going Female Students , 2015 .

[25]  G. Pickering,et al.  Systematic review of endometriosis pain assessment: how to choose a scale? , 2015, Human reproduction update.

[26]  Jen-Chuen Hsieh,et al.  Association of Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism with Primary Dysmenorrhea , 2014, PloS one.

[27]  S. Yardi,et al.  Effect of 12-Weeks of Aerobic Exercise on Primary Dysmennorrhea , 2014 .

[28]  T. Archer,et al.  Physical exercise intervention in depressive disorders: Meta‐analysis and systematic review , 2014, Scandinavian journal of medicine & science in sports.

[29]  L. Claydon,et al.  Some physiotherapy treatments may relieve menstrual pain in women with primary dysmenorrhea: a systematic review. , 2014, Journal of physiotherapy.

[30]  Amimi S. Osayande,et al.  Diagnosis and initial management of dysmenorrhea. , 2014, American family physician.

[31]  M. Kodali,et al.  Effect of Yoga on Primary Dysmenorrhea and Stress in Medical Students , 2013 .

[32]  Z. Rakhshaee Effect of three yoga poses (cobra, cat and fish poses) in women with primary dysmenorrhea: a randomized clinical trial. , 2011, Journal of pediatric and adolescent gynecology.

[33]  Yu-hua Lin,et al.  Selection and efficacy of self-management strategies for dysmenorrhea in young Taiwanese women. , 2011, Journal of clinical nursing.

[34]  T. Vanderah,et al.  Regular Exercise Reverses Sensory Hypersensitivity in a Rat Neuropathic Pain Model: Role of Endogenous Opioids , 2011, Anesthesiology.

[35]  M. Ortiz Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment. , 2010, European journal of obstetrics, gynecology, and reproductive biology.

[36]  Julie Brown,et al.  Exercise for dysmenorrhoea. , 2010, The Cochrane database of systematic reviews.

[37]  S. Najjar,et al.  The Effect of Exercise on Primary Dysmenorrhea , 2006 .

[38]  A. Byrne,et al.  The effect of exercise on depression, anxiety and other mood states: a review. , 1993, Journal of psychosomatic research.

[39]  J. Barchas,et al.  Catecholamines, dopamine, and endorphin levels during extreme exercise. , 1981, The New England journal of medicine.

[40]  A. Frantz,et al.  The effect of running on plasma beta-endorphin. , 1981, Life sciences.