Schizophrenic patients who smoke have a faster finger tapping rate than non-smokers

The increased rate of smoking in schizophrenia patients remains unexplained and may reflect attempts at self-treatment. The effect sought from smoking may be related to nicotine's stimulating action. We tested this hypothesis by examining the relationship between smoking status and finger tapping rate, a measure of central processing, in schizophrenia patients treated with atypical antipsychotics. Smokers showed significantly faster finger tapping rates than non-smokers. This was not related to clinical state, illness chronicity, medication side-effects, antipsychotic dose or plasma concentrations. Nicotine can improve central processing in medicated schizophrenia patients and this may constitute part of the incentive for smoking.

[1]  R. Salokangas,et al.  Effect of smoking on neuroleptics in schizophrenia , 1997, Schizophrenia Research.

[2]  Cynthia G. Wible,et al.  Caudate, putamen, and globus pallidus volume in schizophrenia: A quantitative MRI study , 1995, Psychiatry Research: Neuroimaging.

[3]  G. Simpson,et al.  A RATING SCALE FOR EXTRAPYRAMIDAL SIDE EFFECTS , 1970, Acta psychiatrica Scandinavica. Supplementum.

[4]  N. Andreasen,et al.  Longitudinal study of cognitive function in first-episode and recent-onset schizophrenia. , 1999, The American journal of psychiatry.

[5]  J. Gruzelier,et al.  Neuropsychology, Psychophysiology And Information Processing , 1991 .

[6]  C. Beasley,et al.  Olanzapine. Pharmacokinetic and pharmacodynamic profile. , 1999, Clinical pharmacokinetics.

[7]  P. Newhouse,et al.  The effects of nicotine on Parkinson's disease. , 2000, Brain and cognition.

[8]  Michael F. Green,et al.  Risperidone versus haloperidol for perception of emotion in treatment-resistant schizophrenia: preliminary findings , 1998, Schizophrenia Research.

[9]  J. Shea,et al.  Effects of Smoking Abstinence on Movement Regulation , 2000, Perceptual and motor skills.

[10]  R Freedman,et al.  Schizophrenia, sensory gating, and nicotinic receptors. , 1998, Schizophrenia bulletin.

[11]  A. Radant,et al.  Relationships between Neuropsychological and Oculomotor Measures in Schizophrenia Patients and Normal Controls , 1997, Biological Psychiatry.

[12]  P. Decina,et al.  Cigarette smoking and neuroleptic-induced parkinsonism , 1990, Biological Psychiatry.

[13]  C. Hiemke,et al.  Simultaneous determination of olanzapine, clozapine and demethylated metabolites in serum by on-line column-switching high-performance liquid chromatography. , 2001, Journal of chromatography. B, Biomedical sciences and applications.

[14]  N. Volkow,et al.  Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals. , 1998, The American journal of psychiatry.

[15]  H. Silver,et al.  Perception of facial emotions in chronic schizophrenia does not correlate with negative symptoms but correlates with cognitive and motor dysfunction , 2001, Schizophrenia Research.

[16]  P. Holzman,et al.  A new look at reaction time in schizophrenia , 2000, Schizophrenia Research.

[17]  Michael F. Green,et al.  Risperidone vs. haloperidol on reaction time, manual dexterity, and motor learning in treatment-resistant schizophrenia patients , 1998, Biological Psychiatry.

[18]  M. Hayashi,et al.  An Exploratory Study of Effects of Smoking on Mental Rotation and Mental Paper-Folding Task , 1998, Perceptual and motor skills.

[19]  M. Jahanshahi,et al.  Concurrent performance of motor tasks and processing capacity in patients with schizophrenia , 1999, Journal of neurology, neurosurgery, and psychiatry.

[20]  Leonard H. Epstein,et al.  Behavioral performance effects of nicotine in smokers and nonsmokers , 1990, Pharmacology Biochemistry and Behavior.

[21]  D J Healy,et al.  Nicotine dependence in schizophrenia: clinical phenomena and laboratory findings. , 1998, The American journal of psychiatry.

[22]  L. Balant,et al.  Therapeutic drug monitoring of risperidone using a new, rapid HPLC method: reappraisal of interindividual variability factors. , 1999, Therapeutic drug monitoring.

[23]  J. Overall,et al.  The Brief Psychiatric Rating Scale , 1962 .

[24]  F. Wiesel,et al.  Neurological signs and psychomotor performance in patients with schizophrenia, their relatives and healthy controls , 1999, Psychiatry Research.

[25]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[26]  R. Reitan,et al.  Clinical neuropsychology: Current status and applications. , 1974 .

[27]  A. C. Collins,et al.  Abnormal Regulation of High Affinity Nicotinic Receptors in Subjects with Schizophrenia , 2000, Neuropsychopharmacology.

[28]  L. Dixon,et al.  A focus group pilot study of tobacco smoking among psychosocial rehabilitation clients. , 2000, Psychiatric services.

[29]  N. Andreasen,et al.  Soft signs and neuropsychological performance in schizophrenia. , 1996, The American journal of psychiatry.