论文信息 - Whole-body 18F-fluorodeoxyglucose positron emission tomography in preoperative evaluation of lung cancer

Whole-body 18F-fluorodeoxyglucose positron emission tomography in preoperative evaluation of lung cancer

Despite use of computed tomography, some lung cancer patients are found to have unresectable disease at surgery, or they present early with metastases. We studied whether whole-body positron emission tomography (PET) with 18F-fluorodeoxyglucose (18FDG) would improve the preoperative detection of metastases. We retrospectively analysed 34 patients with "operable" non-small-cell lung cancer who underwent 18FDG PET after routine assessment. Management changes produced by the PET scan and confirmatory tests were reviewed. PET identified unsuspected malignant lesions in 10 (29%) patients. Management changes occurred in 14 (41%), including 6 (18%) patients who were changed to non-surgical therapy. These data suggest that whole-body 18FDG PET improves preoperative assessment of lung cancer patients.

[1] R. Coleman,et al. Focal pulmonary abnormalities: evaluation with F-18 fluorodeoxyglucose PET scanning. , 1993, Radiology.

[2] M E Phelps,et al. Whole-Body Positron Emission Tomography and Fluorodeoxyglucose , 2006 .

[3] J. Dussek,et al. Survival and prognosis following resection of primary non small cell bronchogenic carcinoma. , 1991, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[4] Y. Kuwabara,et al. High [18F]-fluorodeoxyglucose uptake in abdominal abscesses: a PET study. , 1989, Journal of computer assisted tomography.

[5] J. Izbicki,et al. Accuracy of computed tomographic scan and surgical assessment for staging of bronchial carcinoma. A prospective study. , 1992, The Journal of thoracic and cardiovascular surgery.

[6] B J McNeil,et al. CT and MR imaging in staging non-small cell bronchogenic carcinoma: report of the Radiologic Diagnostic Oncology Group. , 1991, Radiology.

[7] J. Sunderland,et al. Solitary pulmonary nodules: detection of malignancy with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose. , 1992, Radiology.

[8] R Iwata,et al. Differential diagnosis of lung tumor with positron emission tomography: a prospective study. , 1990, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.