Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1

[1]  A. Bird,et al.  Affinity for DNA Contributes to NLS Independent Nuclear Localization of MeCP2 , 2018, Cell reports.

[2]  A. Burlingame,et al.  Locally translated mTOR controls axonal local translation in nerve injury , 2018, Science.

[3]  L. Paninski,et al.  Anxiety Cells in a Hippocampal-Hypothalamic Circuit , 2018, Neuron.

[4]  K. Martin,et al.  Regulated transport of signaling proteins from synapse to nucleus , 2017, Current Opinion in Neurobiology.

[5]  T. H. Ch’ng,et al.  Activity-dependent synapse to nucleus signaling , 2017, Neurobiology of Learning and Memory.

[6]  C. Bungener,et al.  Anxiety and Coping Strategy Changes in Multiple Sclerosis Patients Initiating Fingolimod: The GRACE Prospective Study , 2016, European Neurology.

[7]  D. Herr,et al.  To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling. , 2016, Pharmacological research.

[8]  M. Tsoory,et al.  COLORcation: A new application to phenotype exploratory behavior models of anxiety in mice , 2016, Journal of Neuroscience Methods.

[9]  Kohji Yamada,et al.  Importin α: a key molecule in nuclear transport and non-transport functions. , 2016, Journal of biochemistry.

[10]  Heather M. O'Leary,et al.  Anxiety-like behavior in Rett syndrome: characteristics and assessment by anxiety scales , 2015, Journal of Neurodevelopmental Disorders.

[11]  V. Cavalli,et al.  Signaling Over Distances* , 2015, Molecular & Cellular Proteomics.

[12]  H. Zoghbi,et al.  Karyopherin α 3 and Karyopherin α 4 Proteins Mediate the Nuclear Import of Methyl-CpG Binding Protein 2* , 2015, The Journal of Biological Chemistry.

[13]  J. Kornhuber,et al.  Brain membrane lipids in major depression and anxiety disorders. , 2015, Biochimica et biophysica acta.

[14]  D. Charney,et al.  Emerging drugs for the treatment of anxiety , 2015, Expert opinion on emerging drugs.

[15]  A. Lüthi,et al.  Neuronal circuits for fear and anxiety , 2015, Nature Reviews Neuroscience.

[16]  Harrison W. Gabel,et al.  Disruption of DNA methylation-dependent long gene repression in Rett syndrome , 2015, Nature.

[17]  A. Bird,et al.  Rett syndrome: a complex disorder with simple roots , 2015, Nature Reviews Genetics.

[18]  G. Cingolani,et al.  Diversification of importin-α isoforms in cellular trafficking and disease states. , 2015, The Biochemical journal.

[19]  Mike Fainzilber,et al.  Macromolecular transport in synapse to nucleus communication , 2015, Trends in Neurosciences.

[20]  J. Rawlins,et al.  Hippocampal synaptic plasticity, spatial memory and anxiety , 2014, Nature Reviews Neuroscience.

[21]  M. Schwab,et al.  The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity , 2014, PLoS biology.

[22]  M. Fainzilber,et al.  Axon–soma communication in neuronal injury , 2013, Nature Reviews Neuroscience.

[23]  G. Giglia-Mari,et al.  Isoform-specific anti-MeCP2 antibodies confirm that expression of the e1 isoform strongly predominates in the brain , 2013, F1000Research.

[24]  G. Griebel,et al.  50 years of hurdles and hope in anxiolytic drug discovery , 2013, Nature Reviews Drug Discovery.

[25]  Hiroki Kaneko,et al.  Importin alpha subtypes determine differential transcription factor localization in embryonic stem cells maintenance. , 2013, Developmental cell.

[26]  B. Dias,et al.  Towards new approaches to disorders of fear and anxiety , 2013, Current Opinion in Neurobiology.

[27]  C. Spilker,et al.  Encoding and Transducing the Synaptic or Extrasynaptic Origin of NMDA Receptor Signals to the Nucleus , 2013, Cell.

[28]  D. Sieburth,et al.  Localized Sphingolipid Signaling at Presynaptic Terminals Is Regulated by Calcium Influx and Promotes Recruitment of Priming Factors , 2012, The Journal of Neuroscience.

[29]  K. Vogt,et al.  Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome , 2012, Proceedings of the National Academy of Sciences.

[30]  D. Geschwind,et al.  Subcellular Knockout of Importin β1 Perturbs Axonal Retrograde Signaling , 2012, Neuron.

[31]  K. Martin,et al.  Activity-Dependent Transport of the Transcriptional Coactivator CRTC1 from Synapse to Nucleus , 2012, Cell.

[32]  T. Kasten,et al.  Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. , 2012, The Biochemical journal.

[33]  Y. Pilpel,et al.  Axonal transcription factors signal retrogradely in lesioned peripheral nerve , 2012, The EMBO journal.

[34]  E. Kavalali,et al.  A Mouse Model for MeCP2 Duplication Syndrome: MeCP2 Overexpression Impairs Learning and Memory and Synaptic Transmission , 2012, The Journal of Neuroscience.

[35]  Alon Chen,et al.  Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice , 2012, Proceedings of the National Academy of Sciences.

[36]  Rodney C. Samaco,et al.  Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome , 2011, Nature Genetics.

[37]  Michael E. Greenberg,et al.  Rett Syndrome Mutation MeCP2 T158A Disrupts DNA Binding, Protein Stability and ERP Responses , 2011, Nature Neuroscience.

[38]  M. Greenberg,et al.  Neuronal activity-regulated gene transcription in synapse development and cognitive function. , 2011, Cold Spring Harbor perspectives in biology.

[39]  E. Hartmann,et al.  Importin α7 Is Essential for Zygotic Genome Activation and Early Mouse Development , 2011, PloS one.

[40]  E. Hartmann,et al.  Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus , 2011, Nature communications.

[41]  R. Proia,et al.  Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus , 2010, Neuroscience.

[42]  K. Riabowol,et al.  REAP: A two minute cell fractionation method , 2010, BMC Research Notes.

[43]  C. Lowry,et al.  A triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery , 2010, Proceedings of the National Academy of Sciences.

[44]  K. Martin,et al.  Activity-Dependent Anchoring of Importin α at the Synapse Involves Regulated Binding to the Cytoplasmic Tail of the NR1-1a Subunit of the NMDA Receptor , 2009, The Journal of Neuroscience.

[45]  J. Lupski,et al.  Autism and other neuropsychiatric symptoms are prevalent in individuals with MeCP2 duplication syndrome , 2009, Annals of neurology.

[46]  T. Gradus,et al.  Localized Regulation of Axonal RanGTPase Controls Retrograde Injury Signaling in Peripheral Nerve , 2008, Neuron.

[47]  Rodney C. Samaco,et al.  A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome. , 2008, Human molecular genetics.

[48]  J. Crawley,et al.  Behavioral Phenotyping Strategies for Mutant Mice , 2008, Neuron.

[49]  C. Garner,et al.  Caldendrin–Jacob: A Protein Liaison That Couples NMDA Receptor Signalling to the Nucleus , 2008, PLoS biology.

[50]  E. Hartmann,et al.  Normal brain development in importin-α5 deficient-mice , 2007, Nature Cell Biology.

[51]  C. Lowry,et al.  Pharmacology of the beta-carboline FG-7,142, a partial inverse agonist at the benzodiazepine allosteric site of the GABA A receptor: neurochemical, neurophysiological, and behavioral effects. , 2007, CNS drug reviews.

[52]  N. Nag,et al.  Behavioral and anatomical abnormalities in Mecp2 mutant mice: A model for Rett syndrome , 2007, Neuroscience.

[53]  A. Walf,et al.  The use of the elevated plus maze as an assay of anxiety-related behavior in rodents , 2007, Nature Protocols.

[54]  E. Hartmann,et al.  Nuclear Localization Signal and Protein Context both Mediate Importin α Specificity of Nuclear Import Substrates , 2006, Molecular and Cellular Biology.

[55]  K. Ogino,et al.  Extracellular signal-dependent nuclear import of STAT3 is mediated by various importin alphas. , 2005, Biochemical and biophysical research communications.

[56]  K. Martin,et al.  Synapse to Nucleus Signaling during Long-Term Synaptic Plasticity a Role for the Classical Active Nuclear Import Pathway , 2004, Neuron.

[57]  Satoshi Tanaka,et al.  Identification of genetic and epigenetic similarities of SPHK1/Sphk1 in mammals. , 2004, The Journal of veterinary medical science.

[58]  Sylvain V Costes,et al.  Automatic and quantitative measurement of protein-protein colocalization in live cells. , 2004, Biophysical journal.

[59]  M. Koltzenburg,et al.  Axoplasmic Importins Enable Retrograde Injury Signaling in Lesioned Nerve , 2003, Neuron.

[60]  C. Belzung,et al.  The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. , 2003, European journal of pharmacology.

[61]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[62]  K. Davies,et al.  Testing of SHIRPA, a mouse phenotypic assessment protocol, on Dmdmdx and Dmdmdx3cv dystrophin-deficient mice , 2000, Mammalian Genome.

[63]  M. Koch,et al.  The neurobiology of startle , 1999, Progress in Neurobiology.

[64]  S. Tamamizu,et al.  Slow-Channel Transgenic Mice: A Model of Postsynaptic Organellar Degeneration at the Neuromuscular Junction , 1997, The Journal of Neuroscience.

[65]  N. Ogawa,et al.  Pole test is a useful method for evaluating the mouse movement disorder caused by striatal dopamine depletion , 1997, Journal of Neuroscience Methods.

[66]  A. Oliverio,et al.  A gene influencing active avoidance performance in mice. , 1973, Physiology & behavior.

[67]  J. Kornhuber,et al.  Sphingolipids in psychiatric disorders and pain syndromes. , 2013, Handbook of experimental pharmacology.

[68]  Hisato Kondoh,et al.  Triggering neural differentiation of ES cells by subtype switching of importin-α , 2007, Nature Cell Biology.

[69]  P. Skolnick,et al.  Differences in fear motivated behaviors among inbred mouse strains , 2005, Psychopharmacology.